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WormBase Tree Display for Gene: WBGene00001980

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Name Class

WBGene00001980SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namehmr-1Person_evidenceWBPerson498
Sequence_nameW02B9.1
Molecular_name (13)
Other_nameCELE_W02B9.1Accession_evidenceNDBBX284601
Public_namehmr-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhmr
Allele (936)
StrainWBStrain00033419
WBStrain00024209
WBStrain00024233
WBStrain00034583
WBStrain00037750
WBStrain00022481
WBStrain00022484
RNASeq_FPKM (74)
GO_annotation (45)
Ortholog (43)
ParalogWBGene00001475Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00017576Caenorhabditis elegansFrom_analysisPanther
WBGene00022103Caenorhabditis elegansFrom_analysisPanther
WBGene00014914Caenorhabditis elegansFrom_analysismodENCODE_Pseudogenes
WormBase-Compara
Structured_descriptionConcise_descriptionhmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic tissue and body morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody.Paper_evidenceWBPaper00003046
WBPaper00005031
WBPaper00013424
WBPaper00040399
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated16 Nov 2011 00:00:00
Automated_descriptionEnables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSW02B9.1a
W02B9.1b
W02B9.1d
W02B9.1e
Corresponding_CDS_historyW02B9.1a:wp229
W02B9.1c:wp274
Corresponding_transcriptW02B9.1a.1
W02B9.1a.2
W02B9.1b.1
W02B9.1d.1
W02B9.1e.1
Other_sequence (52)
Associated_feature (71)
Experimental_infoRNAi_resultWBRNAi00004929Inferred_automaticallyRNAi_primary
WBRNAi00078672Inferred_automaticallyRNAi_primary
WBRNAi00114289Inferred_automaticallyRNAi_primary
WBRNAi00101418Inferred_automaticallyRNAi_primary
WBRNAi00054578Inferred_automaticallyRNAi_primary
WBRNAi00114172Inferred_automaticallyRNAi_primary
WBRNAi00026457Inferred_automaticallyRNAi_primary
WBRNAi00101406Inferred_automaticallyRNAi_primary
WBRNAi00061085Inferred_automaticallyRNAi_primary
WBRNAi00061086Inferred_automaticallyRNAi_primary
WBRNAi00114093Inferred_automaticallyRNAi_primary
WBRNAi00103824Inferred_automaticallyRNAi_primary
WBRNAi00101421Inferred_automaticallyRNAi_primary
WBRNAi00101409Inferred_automaticallyRNAi_primary
WBRNAi00101427Inferred_automaticallyRNAi_primary
WBRNAi00101424Inferred_automaticallyRNAi_primary
WBRNAi00101420Inferred_automaticallyRNAi_primary
WBRNAi00114133Inferred_automaticallyRNAi_primary
WBRNAi00101405Inferred_automaticallyRNAi_primary
WBRNAi00101425Inferred_automaticallyRNAi_primary
WBRNAi00054577Inferred_automaticallyRNAi_primary
WBRNAi00101423Inferred_automaticallyRNAi_primary
WBRNAi00077362Inferred_automaticallyRNAi_primary
WBRNAi00075305Inferred_automaticallyRNAi_primary
WBRNAi00077370Inferred_automaticallyRNAi_primary
WBRNAi00103843Inferred_automaticallyRNAi_primary
WBRNAi00001716Inferred_automaticallyRNAi_primary
WBRNAi00004701Inferred_automaticallyRNAi_primary
WBRNAi00112567Inferred_automaticallyRNAi_primary
WBRNAi00114212Inferred_automaticallyRNAi_primary
WBRNAi00108354Inferred_automaticallyRNAi_primary
WBRNAi00091285Inferred_automaticallyRNAi_primary
WBRNAi00069108Inferred_automaticallyRNAi_primary
WBRNAi00071059Inferred_automaticallyRNAi_primary
WBRNAi00063122Inferred_automaticallyRNAi_primary
WBRNAi00114250Inferred_automaticallyRNAi_primary
WBRNAi00101422Inferred_automaticallyRNAi_primary
WBRNAi00101408Inferred_automaticallyRNAi_primary
WBRNAi00101419Inferred_automaticallyRNAi_primary
WBRNAi00077369Inferred_automaticallyRNAi_primary
WBRNAi00114054Inferred_automaticallyRNAi_primary
WBRNAi00071899Inferred_automaticallyRNAi_primary
WBRNAi00101433Inferred_automaticallyRNAi_primary
WBRNAi00101416Inferred_automaticallyRNAi_primary
WBRNAi00101415Inferred_automaticallyRNAi_primary
WBRNAi00026456Inferred_automaticallyRNAi_primary
WBRNAi00103844Inferred_automaticallyRNAi_primary
WBRNAi00091281Inferred_automaticallyRNAi_primary
WBRNAi00061084Inferred_automaticallyRNAi_primary
WBRNAi00093061Inferred_automaticallyRNAi_primary
WBRNAi00077674Inferred_automaticallyRNAi_primary
WBRNAi00114014Inferred_automaticallyRNAi_primary
WBRNAi00101407Inferred_automaticallyRNAi_primary
WBRNAi00110279Inferred_automaticallyRNAi_primary
WBRNAi00101426Inferred_automaticallyRNAi_primary
WBRNAi00061082Inferred_automaticallyRNAi_primary
WBRNAi00101434Inferred_automaticallyRNAi_primary
WBRNAi00108356Inferred_automaticallyRNAi_primary
WBRNAi00061083Inferred_automaticallyRNAi_primary
WBRNAi00004369Inferred_automaticallyRNAi_primary
WBRNAi00054576Inferred_automaticallyRNAi_primary
Expr_pattern (17)
Drives_construct (11)
Construct_productWBCnstr00006080
WBCnstr00010445
WBCnstr00014624
WBCnstr00014629
WBCnstr00014630
WBCnstr00014636
WBCnstr00020940
WBCnstr00021692
WBCnstr00021693
WBCnstr00023099
AntibodyWBAntibody00000169
WBAntibody00002173
WBAntibody00002591
WBAntibody00002643
WBAntibody00002693
Microarray_results (38)
Expression_cluster (173)
Interaction (109)
WBProcessWBbiopr:00000073
Map_infoMapIPosition6.60962Error0.05706
PositivePositive_cloneW02B9Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4410
4851
4818
5481
Pseudo_map_position
Reference (111)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene