WormBase Tree Display for Gene: WBGene00001980

WBGene00001980 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: hmr-1 Person_evidence: WBPerson498
      Sequence_name: W02B9.1
      Molecular_name (13)
      Other_name: CELE_W02B9.1 Accession_evidence: NDB BX284601
      Public_name: hmr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hmr
    Allele (936)
    Strain: WBStrain00033419
      WBStrain00024209
      WBStrain00024233
      WBStrain00034583
      WBStrain00037750
      WBStrain00022481
      WBStrain00022484
    RNASeq_FPKM (74)
    GO_annotation (45)
    Ortholog (43)
    Paralog: WBGene00001475 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00017576 Caenorhabditis elegans From_analysis: Panther
      WBGene00022103 Caenorhabditis elegans From_analysis: Panther
      WBGene00014914 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
            WormBase-Compara
    Structured_description: Concise_description: hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic tissue and body morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody. Paper_evidence: WBPaper00003046
            WBPaper00005031
            WBPaper00013424
            WBPaper00040399
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 16 Nov 2011 00:00:00
      Automated_description: Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction; distal dendrite; and plasma membrane. Part of catenin complex. Expressed in several structures, including germline precursor cell; hypodermis; motor neurons; nerve ring; and neuroblasts. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: W02B9.1a
      W02B9.1b
      W02B9.1d
      W02B9.1e
    Corresponding_CDS_history: W02B9.1a:wp229
      W02B9.1c:wp274
    Corresponding_transcript: W02B9.1a.1
      W02B9.1a.2
      W02B9.1b.1
      W02B9.1d.1
      W02B9.1e.1
    Other_sequence (52)
    Associated_feature (71)
  Experimental_info: RNAi_result (61)
    Expr_pattern (17)
    Drives_construct (11)
    Construct_product: WBCnstr00006080
      WBCnstr00010445
      WBCnstr00014624
      WBCnstr00014629
      WBCnstr00014630
      WBCnstr00014636
      WBCnstr00020940
      WBCnstr00021692
      WBCnstr00021693
      WBCnstr00023099
    Antibody: WBAntibody00000169
      WBAntibody00002173
      WBAntibody00002591
      WBAntibody00002643
      WBAntibody00002693
    Microarray_results (38)
    Expression_cluster (173)
    Interaction (109)
    WBProcess: WBbiopr:00000073
  Map_info: Map: I Position: 6.60962 Error: 0.05706
    Positive: Positive_clone: W02B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4410
        4851
        4818
        5481
    Pseudo_map_position
  Reference: WBPaper00003046
    WBPaper00003991
    WBPaper00004214
    WBPaper00004237
    WBPaper00004402
    WBPaper00004438
    WBPaper00004493
    WBPaper00004508
    WBPaper00004510
    WBPaper00004964
    WBPaper00005031
    WBPaper00005256
    WBPaper00005372
    WBPaper00005423
    WBPaper00005576
    WBPaper00005969
    WBPaper00005972
    WBPaper00005975
    WBPaper00006149
    WBPaper00006196
    WBPaper00006199
    WBPaper00006382
    WBPaper00006400
    WBPaper00006419
    WBPaper00006422
    WBPaper00006462
    WBPaper00011479
    WBPaper00011581
    WBPaper00011597
    WBPaper00012424
    WBPaper00013424
    WBPaper00013425
    WBPaper00016638
    WBPaper00017732
    WBPaper00017740
    WBPaper00017984
    WBPaper00018030
    WBPaper00022212
    WBPaper00022650
    WBPaper00023815
    WBPaper00024189
    WBPaper00024261
    WBPaper00024525
    WBPaper00026108
    WBPaper00026188
    WBPaper00026609
    WBPaper00026643
    WBPaper00026769
    WBPaper00027230
    WBPaper00027233
    WBPaper00027244
    WBPaper00027245
    WBPaper00027345
    WBPaper00027973
    WBPaper00029033
    WBPaper00029082
    WBPaper00029128
    WBPaper00030820
    WBPaper00031082
    WBPaper00031185
    WBPaper00031422
    WBPaper00032115
    WBPaper00032467
    WBPaper00032951
    WBPaper00036179
    WBPaper00036205
    WBPaper00036330
    WBPaper00037766
    WBPaper00038491
    WBPaper00038590
    WBPaper00038633
    WBPaper00039779
    WBPaper00039809
    WBPaper00040399
    WBPaper00041166
    WBPaper00041326
    WBPaper00042711
    WBPaper00042772
    WBPaper00043621
    WBPaper00046634
    WBPaper00046645
    WBPaper00046751
    WBPaper00048287
    WBPaper00048594
    WBPaper00048639
    WBPaper00050540
    WBPaper00050944
    WBPaper00051878
    WBPaper00052175
    WBPaper00052187
    WBPaper00052700
    WBPaper00055090
    WBPaper00056223
    WBPaper00056291
    WBPaper00056323
    WBPaper00056801
    WBPaper00056902
    WBPaper00057858
    WBPaper00058384
    WBPaper00058442
    WBPaper00060556
    WBPaper00060888
    WBPaper00061994
    WBPaper00062715
    WBPaper00063074
    WBPaper00064244
    WBPaper00064606
    WBPaper00064685
    WBPaper00064805
    WBPaper00065559
    WBPaper00065869
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene