WormBase Tree Display for Gene: WBGene00002150

WBGene00002150 SMap: S_parent: Sequence: M02A10
  Identity: Version: 1
    Name: CGC_name: irk-2 Person_evidence: WBPerson655
      Sequence_name: M02A10.2
      Molecular_name (19)
      Other_name: CELE_M02A10.2 Accession_evidence: NDB BX284606
      Public_name: irk-2
    DB_info: Database: AceView gene XB322
        WormQTL gene WBGene00002150
        WormFlux gene WBGene00002150
        NDB locus_tag CELE_M02A10.2
        Panther gene CAEEL|WormBase=WBGene00002150|UniProtKB=A0A1C3NSN6
          family PTHR11767
        NCBI gene 191695
        RefSeq protein NM_001330888.3
            NM_001270048.3
            NM_001380895.1
            NM_001380896.1
            NM_001307921.4
            NM_001270047.4
        TrEMBL UniProtAcc A0A1C3NSN6
            H2KYE6
            D3YT08
            A0A1C3NSR3
            U4PSB4
            U4PN13
        UniProt_GCRP UniProtAcc A0A1C3NSN6
        OMIM gene 600681
            600734
            600937
            613236
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: irk
    Allele (166)
    Legacy_information: [Thomas JH] irk for Inward Rectifying potassium (K) channel family. Predicted gene M02A10.2
    Strain: WBStrain00037929
      WBStrain00039809
      WBStrain00047557
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00029984 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00060245 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00151452 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00081691 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00068445 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00131743 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00124865 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00225321 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3543 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g2885 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1903 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g11484 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16582 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g15647 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g15649 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP40.g4242 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00309.g8965 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-irk-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15639 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00191.g6662 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_01910.g23834 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03214 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022192 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12901 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12903 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2251 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0018000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18317 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242305 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00203627 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00265657 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293214 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0265042 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0039081 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050222-2 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-120215-38 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-060308-1 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-070424-22 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-131127-162 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-091204-290 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-120319-1 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-131126-14 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-120327-2 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060503-706 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-120215-97 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-091118-79 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-121214-60 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-100922-16 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-160216-3 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-081104-42 Danio rerio From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-100922-48 Danio rerio From_analysis: Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6263 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6264 Homo sapiens From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:6265 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6266 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6267 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6270 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6257 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:6258 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6260 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:6262 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:39080 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:108495 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1314842 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      MGI:104744 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:104742 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:104743 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:104755 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:104781 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1100508 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      MGI:108007 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2384820 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2960 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:2959 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:61968 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:61971 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2958 Rattus norvegicus From_analysis: Hieranoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:69247 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:621440 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621436 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621660 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:628872 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00002149 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00002151 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. Paper_evidence: WBPaper00006402
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in intestine; pharyngeal-intestinal valve cell; spermatheca; and uterus. Human ortholog(s) of this gene implicated in several diseases, including glucose metabolism disease (multiple); heart conduction disease (multiple); and long QT syndrome (multiple). Is an ortholog of several human genes including KCNJ2 (potassium inwardly rectifying channel subfamily J member 2); KCNJ4 (potassium inwardly rectifying channel subfamily J member 4); and KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (16)
  Molecular_info: Corresponding_CDS: M02A10.2a
      M02A10.2b
      M02A10.2c
      M02A10.2d
      M02A10.2e
      M02A10.2f
    Corresponding_CDS_history: M02A10.2:wp204
      M02A10.2b:wp239
    Corresponding_transcript: M02A10.2a.1
      M02A10.2a.2
      M02A10.2b.1
      M02A10.2c.1
      M02A10.2d.1
      M02A10.2e.1
      M02A10.2f.1
    Other_sequence (12)
    Associated_feature: WBsf1003844
      WBsf1003845
      WBsf1003846
      WBsf1022163
      WBsf236953
  Experimental_info: RNAi_result: WBRNAi00050801 Inferred_automatically: RNAi_primary
      WBRNAi00017113 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr16176
      Expr16177
      Expr16178
      Expr1015830
      Expr1154493
      Expr2012824
      Expr2031062
    Drives_construct: WBCnstr00036415
      WBCnstr00042793
    Construct_product: WBCnstr00036415
      WBCnstr00042793
    Microarray_results (22)
    Expression_cluster (88)
    Interaction (15)
  Map_info: Map: X Position: -19.5082
    Positive: Positive_clone: M02A10 Person_evidence: WBPerson654
            WBPerson655
          Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00006402
    WBPaper00028146
    WBPaper00034195
    WBPaper00038491
    WBPaper00055090
    WBPaper00059550
    WBPaper00064330
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene