WormBase Tree Display for Gene: WBGene00002215

WBGene00002215 SMap: S_parent: Sequence: C18C4
  Identity: Version: 1
    Name: CGC_name: klc-2 Person_evidence: WBPerson589
      Sequence_name: C18C4.10
      Molecular_name (11)
      Other_name: CELE_C18C4.10 Accession_evidence: NDB BX284605
      Public_name: klc-2
    DB_info: Database: AceView gene 5G58
        WormQTL gene WBGene00002215
        WormFlux gene WBGene00002215
        NDB locus_tag CELE_C18C4.10
        Panther gene CAEEL|WormBase=WBGene00002215|UniProtKB=P46822
          family PTHR45783
        NCBI gene 178942
        RefSeq protein NM_001028493.7
            NM_001028494.5
            NM_001028492.5
        SwissProt UniProtAcc P46822
        UniProt_GCRP UniProtAcc P46822
        OMIM gene 611729
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: klc
    Allele (67)
    Legacy_information: [Siddiqui SS ] Predicted gene C18C4.10. Related to kinesin light chain by sequence similarity.
    Strain: WBStrain00001630
      WBStrain00050735
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog: WBGene00058915 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00030964 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00030965 Caenorhabditis briggsae From_analysis: OrthoMCL
            WormBase-Compara
      WBGene00143153 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00145025 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00154291 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00193909 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00138153 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00091182 Pristionchus pacificus From_analysis: OMA
      WBGene00222560 Brugia malayi From_analysis: WormBase-Compara
      WBGene00228530 Brugia malayi From_analysis: WormBase-Compara
      WBGene00229293 Brugia malayi From_analysis: WormBase-Compara
      WBGene00231707 Brugia malayi From_analysis: WormBase-Compara
      WBGene00232560 Brugia malayi From_analysis: WormBase-Compara
      WBGene00268381 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2116 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g15081 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8949 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g15818 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g14180 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18009 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g102 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9915 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21812 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24629 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00246.g7820 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_V.g19687 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_V.g19689 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold460.g1464 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00484.g11964 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_07969.g38312 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_12026 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017760 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00164 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g7523 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g7527 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50196610 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g14268 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243193 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00264614 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285072 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296864 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0010235 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1599 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050417-350 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060929-772 Danio rerio From_analysis: OrthoFinder
            Panther
            PhylomeDB
      HGNC:6387 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20716 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:21624 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20717 Homo sapiens From_analysis: OrthoFinder
            Panther
            PhylomeDB
      MGI:107978 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:107953 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1922014 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1277971 Mus musculus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:621411 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:621432 Rattus norvegicus From_analysis: OrthoFinder
            Panther
            PhylomeDB
      RGD:1307377 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1306555 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00002214 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization. Paper_evidence: WBPaper00004211
            WBPaper00005014
            WBPaper00005076
            WBPaper00024617
            WBPaper00025176
            WBPaper00026866
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 13 Mar 2009 00:00:00
      Automated_description: Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:2378 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6387)
      DOID:0060491 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:20716)
  Molecular_info: Corresponding_CDS: C18C4.10a
      C18C4.10b
      C18C4.10c
    Corresponding_CDS_history: C18C4.10b:wp90
      C18C4.10d:wp261
    Corresponding_transcript: C18C4.10a.1
      C18C4.10b.1
      C18C4.10b.2
      C18C4.10b.3
      C18C4.10c.1
    Other_sequence (99)
    Associated_feature (19)
  Experimental_info: RNAi_result (12)
    Expr_pattern: Chronogram513
      Expr3209
      Expr5301
      Expr8662
      Expr1012871
      Expr1031295
      Expr1144957
      Expr2012948
      Expr2031180
    Drives_construct: WBCnstr00002469
      WBCnstr00036381
    Construct_product: WBCnstr00036381
    Antibody: WBAntibody00001660
      WBAntibody00002831
    Microarray_results (43)
    Expression_cluster (138)
    Interaction (91)
  Map_info: Map: V Position: -1.48452 Error: 0.026086
    Positive: Positive_clone: C18C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4462
        4944
        5254
    Pseudo_map_position
  Reference (36)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene