WormBase Tree Display for Gene: WBGene00002215
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WBGene00002215 | SMap | S_parent | Sequence | C18C4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | klc-2 | Person_evidence | WBPerson589 | |||||
Sequence_name | C18C4.10 | ||||||||
Molecular_name (11) | |||||||||
Other_name | CELE_C18C4.10 | Accession_evidence | NDB | BX284605 | |||||
Public_name | klc-2 | ||||||||
DB_info | Database | AceView | gene | 5G58 | |||||
WormQTL | gene | WBGene00002215 | |||||||
WormFlux | gene | WBGene00002215 | |||||||
NDB | locus_tag | CELE_C18C4.10 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00002215|UniProtKB=P46822 | |||||||
family | PTHR45783 | ||||||||
NCBI | gene | 178942 | |||||||
RefSeq | protein | NM_001028493.7 | |||||||
NM_001028494.5 | |||||||||
NM_001028492.5 | |||||||||
SwissProt | UniProtAcc | P46822 | |||||||
UniProt_GCRP | UniProtAcc | P46822 | |||||||
OMIM | gene | 611729 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | klc | ||||||||
Allele (67) | |||||||||
Legacy_information | [Siddiqui SS ] Predicted gene C18C4.10. Related to kinesin light chain by sequence similarity. | ||||||||
Strain | WBStrain00001630 | ||||||||
WBStrain00050735 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog (58) | |||||||||
Paralog | WBGene00002214 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization. | Paper_evidence | WBPaper00004211 | |||||
WBPaper00005014 | |||||||||
WBPaper00005076 | |||||||||
WBPaper00024617 | |||||||||
WBPaper00025176 | |||||||||
WBPaper00026866 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson324 | |||||||||
Date_last_updated | 13 Mar 2009 00:00:00 | ||||||||
Automated_description | Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||
DOID:2378 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||||
DOID:0060491 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20716) | ||||||
Molecular_info | Corresponding_CDS | C18C4.10a | |||||||
C18C4.10b | |||||||||
C18C4.10c | |||||||||
Corresponding_CDS_history | C18C4.10b:wp90 | ||||||||
C18C4.10d:wp261 | |||||||||
Corresponding_transcript | C18C4.10a.1 | ||||||||
C18C4.10b.1 | |||||||||
C18C4.10b.2 | |||||||||
C18C4.10b.3 | |||||||||
C18C4.10c.1 | |||||||||
Other_sequence | EX560440.1 | ||||||||
HG08628 | |||||||||
EX537386.1 | |||||||||
JI168446.1 | |||||||||
EX012434.1 | |||||||||
CR00977 | |||||||||
FG582482.1 | |||||||||
SS03034 | |||||||||
Tcir_isotig14292 | |||||||||
EX550627.1 | |||||||||
MC04243 | |||||||||
EY469448.1 | |||||||||
BMC03573_1 | |||||||||
FC548884.1 | |||||||||
FC554215.1 | |||||||||
BMC03111_1 | |||||||||
FC554277.1 | |||||||||
Tcol_isotig14038 | |||||||||
NB10990 | |||||||||
FC550483.1 | |||||||||
EY471329.1 | |||||||||
CJC01353_1 | |||||||||
ACC03781_1 | |||||||||
CBC08130_1 | |||||||||
FK804975.1 | |||||||||
FC813978.1 | |||||||||
CRC06275_1 | |||||||||
FC819938.1 | |||||||||
FC540426.1 | |||||||||
EY462209.1 | |||||||||
MAC00085_1 | |||||||||
FC540492.1 | |||||||||
Dviv_isotig11613 | |||||||||
SRC06508_1 | |||||||||
EY468827.1 | |||||||||
ES569000.1 | |||||||||
AE04754 | |||||||||
FC546997.1 | |||||||||
Acan_isotig01134 | |||||||||
JI219008.1 | |||||||||
FC548924.1 | |||||||||
FC552983.1 | |||||||||
EW741973.1 | |||||||||
EY467781.1 | |||||||||
MHC00254_1 | |||||||||
MH03172 | |||||||||
EX549123.1 | |||||||||
ACC12318_1 | |||||||||
JI165746.1 | |||||||||
ES273631.1 | |||||||||
Dviv_isotig11612 | |||||||||
FC543858.1 | |||||||||
HGC03490_1 | |||||||||
SRC08862_1 | |||||||||
MCC03374_1 | |||||||||
CBC09757_1 | |||||||||
Tcir_isotig06696 | |||||||||
CR05819 | |||||||||
MA00658 | |||||||||
FC549590.1 | |||||||||
CJC12899_1 | |||||||||
ACC06624_1 | |||||||||
FC554193.1 | |||||||||
MP00123 | |||||||||
AYC03754_1 | |||||||||
EY463691.1 | |||||||||
EY470609.1 | |||||||||
EY465562.1 | |||||||||
SSC05341_1 | |||||||||
EY458541.1 | |||||||||
SR04704 | |||||||||
MIC05800_1 | |||||||||
EY466167.1 | |||||||||
FF681312.1 | |||||||||
MI06271 | |||||||||
Dviv_isotig11611 | |||||||||
TSC07749_1 | |||||||||
Acan_isotig01135 | |||||||||
XI05006 | |||||||||
EY458805.1 | |||||||||
ES742394.1 | |||||||||
Hbac_isotig01869 | |||||||||
FC547767.1 | |||||||||
FC549008.1 | |||||||||
EY469813.1 | |||||||||
CBC01746_1 | |||||||||
BMC12444_1 | |||||||||
EX562082.1 | |||||||||
FC553067.1 | |||||||||
CRC07335_1 | |||||||||
Oden_isotig18992 | |||||||||
HGC03829_1 | |||||||||
MPC00008_1 | |||||||||
XIC05685_1 | |||||||||
EY459674.1 | |||||||||
EY458695.1 | |||||||||
FC547185.1 | |||||||||
HBC02736_1 | |||||||||
FC542090.1 | |||||||||
Associated_feature (19) | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern | Chronogram513 | ||||||||
Expr3209 | |||||||||
Expr5301 | |||||||||
Expr8662 | |||||||||
Expr1012871 | |||||||||
Expr1031295 | |||||||||
Expr1144957 | |||||||||
Expr2012948 | |||||||||
Expr2031180 | |||||||||
Drives_construct | WBCnstr00002469 | ||||||||
WBCnstr00036381 | |||||||||
Construct_product | WBCnstr00036381 | ||||||||
Antibody | WBAntibody00001660 | ||||||||
WBAntibody00002831 | |||||||||
Microarray_results (43) | |||||||||
Expression_cluster (138) | |||||||||
Interaction (91) | |||||||||
Map_info | Map | V | Position | -1.48452 | Error | 0.026086 | |||
Positive | Positive_clone | C18C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4462 | |||||||
4944 | |||||||||
5254 | |||||||||
Pseudo_map_position | |||||||||
Reference (36) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |