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WormBase Tree Display for Gene: WBGene00002239

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Name Class

WBGene00002239SMapS_parentSequenceF13B9
IdentityVersion1
NameCGC_nameksr-1Person_evidenceWBPerson237
Sequence_nameF13B9.5
Molecular_nameF13B9.5
F13B9.5.1
CE25854
Other_namesur-3
sar-2
CELE_F13B9.5Accession_evidenceNDBBX284606
Public_nameksr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classksr
Allele (175)
Legacy_information[Kornfeld K] ksr for kinase suppressor of ras. ksr-1 loss-of-function mutations suppress the multivulva phenotype caused by let-60(n1046gf), cause a very low penetrance defect in vulval lineages, and cause about 10% larval lethality with a characteristic rod-like morphology.
[C.elegansII] pka sur-3, sar-2. Mutations suppress ras mutation,let-60(n1046gf). No phenotype alone in VPC; some larval lethality, Egl and Mig phenotypes. [MT; MH]
StrainWBStrain00026498
WBStrain00026503
WBStrain00027335
WBStrain00027336
WBStrain00027337
WBStrain00031627
RNASeq_FPKM (74)
GO_annotation (25)
OrthologWBGene00058806Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00041222Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00154476Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00126881Caenorhabditis japonicaFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00115552Pristionchus pacificusFrom_analysisInparanoid_8
WormBase-Compara
WBGene00223588Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g2694Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g164Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g18495Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g20834Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g23074Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g11994Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g3915Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g9032Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g9083Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g2664Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00383.g10074Caenorhabditis angariaFrom_analysisWormBase-Compara
Cnig_chr_X.g25559Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g10181Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00093.g4067Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_01981Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_025345Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04763Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g22590Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0160400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g19547Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00245774Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00262832Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00297829Trichuris murisFrom_analysisWormBase-Compara
WBGene00300945Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0015402Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-040724-45Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-030131-8047Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-091113-34Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:6465Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:18610Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:105051Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:3610315Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:1562674Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:1308105Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
Paralog (11)
Structured_descriptionConcise_descriptionksr-1 encodes one of two C. elegans Kinase Suppressor of Ras paralogs; during development, ksr-1 functions singly to control sex myoblast migration and redundantly with ksr-2 to control development of the vulva, excretory system, and male spicules; as ksr-2; ksr-1 doubly mutant animals have severely reduced or absent MPK-1/ERK diphosphorylation levels in somatic tissue, KSR-2 and KSR-1 likely function to positively regulate signaling through the LET-60/Ras pathway; genetic analyses have identified a number of ekl (enhancer of ksr-1 lethality ) mutations that, in combination with a ksr-1 null mutation, result in defects in excretory duct cell fate specification accompanied by larval lethality; the ekl mutations identified gene products that are maternally required for duct cell fate specification and encode proteins likely to be involved in transcriptional and post-transcriptional gene regulation.Paper_evidenceWBPaper00002350
WBPaper00002351
WBPaper00005155
WBPaper00031487
Curator_confirmedWBPerson1843
Date_last_updated12 May 2009 00:00:00
Automated_descriptionEnables mitogen-activated protein kinase kinase binding activity and protein kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; myoblast migration; and positive regulation of vulval development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Is an ortholog of human KSR1 (kinase suppressor of ras 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3458Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6465)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6465)
Molecular_infoCorresponding_CDSF13B9.5
Corresponding_transcriptF13B9.5.1
Other_sequence (19)
Associated_featureWBsf663032
WBsf1006098
WBsf1006099
WBsf1006100
WBsf1023389
WBsf1023390
WBsf236034
Experimental_infoRNAi_result (11)
Expr_patternExpr1011978
Expr1031314
Expr1148436
Expr2012981
Expr2031213
Drives_constructWBCnstr00036367
Construct_productWBCnstr00036367
Microarray_results (25)
Expression_cluster (96)
Interaction (99)
WBProcessWBbiopr:00000071
Map_infoMapXPosition-0.200671Error0.016778
Well_ordered
PositivePositive_cloneC33E9Person_evidenceWBPerson341
F13B9Person_evidenceWBPerson341
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3616
4468
Reference (102)
MethodGene