WormBase Tree Display for Gene: WBGene00003004

WBGene00003004 Identity: Version: 5
    Name: CGC_name: lin-15
      Other_name: lin-15AB
      Public_name: lin-15
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 24 Aug 2004 15:50:19 WBPerson1971 Event: Split_into: WBGene00023497
        3 24 Aug 2004 15:51:08 WBPerson1971 Event: Split_into: WBGene00023498
        4 25 Aug 2004 09:25:59 WBPerson1971 Event: Killed
        5 21 Dec 2004 15:25:37 WBPerson2970 Event: Resurrected
      Split_into: WBGene00023497
        WBGene00023498
    Status: Live
  Gene_info: Gene_class: lin
    Allele: WBVar00089736 Inferred_automatically: From strain object: ZM9624
    Strain (40)
    Structured_description: Concise_description: lin-15 is a complex locus containing two non-overlapping transcripts, lin-15A and lin-15B, separated by less than 150 bp and transcribed in the same direction. LIN-15A and B proteins are novel and have a THAP zinc-finger-like (C2CH) motif. The lin-15A transcript is processed with the addition of an SL1 or and SL2 trans-splice leader. lin-15B has only been shown to have an SL1 added. These features suggest the lin-15 locus encodes a single polycistronic mRNA. Alleles of lin-15 were first obtained based on the Multivulva (Muv) phenotype. More alleles were identified in screens for vulval cell lineage mutants, where all six vulval precursor cells (VPCs) adopt vulval fates, causing the Muv phenotype. Initial studies of these alleles showed lin-15 to have two independently mutable activities, A and B; A and B class Muv genes were defined by synthetic genetic interactions with lin-8 and lin-9, respectively. Homozygous class A or B mutants do not exhibit any vulval phenotypes whereas A+B double homozygotes are Syn-Muv. While some lin-15 alleles fall into either the A OR B classes, for example, n767 and n744 respectively, most of the alleles are Muv as homozygotes alone and hence are AB mutants, for example, n765. Molecular analysis showed that the lin-15 locus comprised two independent transcripts with the downstream transcript encoding lin-15A function and the upstream transcript encoding lin-15B function. A and B mutant alleles alter the downstream and upstream functions, respectively, and AB alleles affect both transcripts. Further, all single homozyogus Muv alleles proved to be rearrangements or deletions in the lin-15 locus. Although A and B functions are genetically redundant, A function can not rescue B function and thus A and B are not molecularly redundant. Fragments of the lin-15 locus that rescue either lin-15A or lin-15B are common and useful coinjection transgenic markers when using a lin-15(n765tsAB) mutant background. Paper_evidence: WBPaper00001949
            WBPaper00000762
            WBPaper00001182
            WBPaper00000957
            WBPaper00001990
          Curator_confirmed: WBPerson712
          Date_last_updated: 23 Jan 2014 00:00:00
  Experimental_info: Drives_construct: WBCnstr00019443
    Construct_product: WBCnstr00019443
    Interaction: WBInteraction000000065
      WBInteraction000000066
      WBInteraction000000075
      WBInteraction000000076
      WBInteraction000000082
      WBInteraction000000111
      WBInteraction000000113
      WBInteraction000000114
      WBInteraction000000115
      WBInteraction000000121
      WBInteraction000000125
      WBInteraction000000160
      WBInteraction000000213
      WBInteraction000000214
      WBInteraction000000220
      WBInteraction000000222
      WBInteraction000000224
      WBInteraction000000246
      WBInteraction000000525
      WBInteraction000000579
      WBInteraction000000580
      WBInteraction000000583
      WBInteraction000000586
      WBInteraction000000664
      WBInteraction000000669
      WBInteraction000000684
      WBInteraction000000743
      WBInteraction000001095
      WBInteraction000001099
      WBInteraction000001120
      WBInteraction000001238
      WBInteraction000001569
      WBInteraction000001570
      WBInteraction000002016
      WBInteraction000002029
      WBInteraction000002474
      WBInteraction000002672
      WBInteraction000002833
      WBInteraction000003054
      WBInteraction000003864
      WBInteraction000003865
      WBInteraction000003866
      WBInteraction000004830
      WBInteraction000005004
      WBInteraction000005005
      WBInteraction000005006
      WBInteraction000005014
      WBInteraction000005015
      WBInteraction000005016
      WBInteraction000005037
      WBInteraction000005062
      WBInteraction000005063
      WBInteraction000005089
      WBInteraction000005090
      WBInteraction000005230
      WBInteraction000005234
      WBInteraction000005280
      WBInteraction000005281
      WBInteraction000005282
      WBInteraction000005306
      WBInteraction000005492
      WBInteraction000051554
      WBInteraction000051555
      WBInteraction000051556
      WBInteraction000051557
      WBInteraction000051558
      WBInteraction000051559
      WBInteraction000051560
      WBInteraction000051561
      WBInteraction000051562
      WBInteraction000051563
      WBInteraction000051564
      WBInteraction000051565
      WBInteraction000051566
      WBInteraction000051567
      WBInteraction000051568
      WBInteraction000051569
      WBInteraction000051570
      WBInteraction000051571
      WBInteraction000051572
      WBInteraction000051573
      WBInteraction000051574
      WBInteraction000051575
      WBInteraction000051576
      WBInteraction000051577
      WBInteraction000051578
      WBInteraction000051579
      WBInteraction000051580
      WBInteraction000051581
      WBInteraction000051582
      WBInteraction000051583
      WBInteraction000051584
      WBInteraction000051585
      WBInteraction000051586
      WBInteraction000051587
      WBInteraction000051588
      WBInteraction000051589
      WBInteraction000051685
      WBInteraction000051686
      WBInteraction000051687
      WBInteraction000051688
      WBInteraction000051689
      WBInteraction000051690
      WBInteraction000051691
      WBInteraction000051692
      WBInteraction000051693
      WBInteraction000051694
      WBInteraction000051695
      WBInteraction000051696
      WBInteraction000052124
      WBInteraction000500334
      WBInteraction000500662
      WBInteraction000500663
      WBInteraction000519982
      WBInteraction000519983
      WBInteraction000519984
      WBInteraction000519985
      WBInteraction000523931
      WBInteraction000524055
      WBInteraction000524056
      WBInteraction000524057
      WBInteraction000524397
      WBInteraction000524410
      WBInteraction000524413
      WBInteraction000556891
      WBInteraction000556892
      WBInteraction000502392
  Map_info: Mapping_data: 2_point: 4457
        4458
        6060
        7015
        7082
      Multi_point (33)
      Pos_neg_data: 491
        518
        519
        536
        4461
  Reference (24)
  Remark: At the instruction of the Gene Nomenclature Committee this gene has been split into two separate genes. lin-15 has been a long-standing special case as it is really two separate genes adjacent to each other within an operon. The literature often treats this gene as two separate genes and refers to them accordingly as lin-15A and lin-15B. These will become the new approved names for the two separate genes. [040824 krb]
    This gene has been resurrected becauase it is referred to by other objects. It does not have a approved name [041221 mt3]
  Method: Gene