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WormBase Tree Display for Variation: WBVar00089736

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Name Class

WBVar00089736EvidencePaper_evidenceWBPaper00032289
NamePublic_namen765
Other_nameCE15381:p.Pro208LysfsTer16
ZK662.4.2:c.622_812del
ZK662.4.1:c.622_812del
HGVSgCHROMOSOME_X:g.15727663_15727853del
Sequence_detailsSMapS_parentSequenceZK678
Flanking_sequencesTCAAATGTCAAGTTTACGAACATTGTGTGTAAGGTAAATTTAGCGTTTTTAACCTTTATA
Mapping_targetZK678
Type_of_mutationInsertion
Deletion
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (179)
LaboratoryMT
NM
CX
StatusLive
AffectsGeneWBGene00003004
WBGene00023498
WBGene00023497
TranscriptZK662.4.1VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScZK662.4.1:c.622_812del
HGVSpCE15381:p.Pro208LysfsTer16
cDNA_position628-818
CDS_position622-812
Protein_position208-271
Exon_number4/10
Codon_changeCCAAACGAAGAGATTTGCAAGCTGGTTGAAGAGAGTGCAGTTGTCAAACGATACAACGTTTGCTTCTACAACTACGTTACCCGTTTTGTGGCCGATTTGATGGAAATTGAAGAGTTTTCCAGTGGGCTGACACAATTGCGAACATTTGTTCGTTATATGAAACAAAATTCGGATATGTATAGCAAATTTAGa/a
Amino_acid_changePNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFR/X
ZK662.4.2VEP_consequenceframeshift_variant
VEP_impactHIGH
HGVScZK662.4.2:c.622_812del
HGVSpCE15381:p.Pro208LysfsTer16
cDNA_position634-824
CDS_position622-812
Protein_position208-271
Exon_number4/11
Codon_changeCCAAACGAAGAGATTTGCAAGCTGGTTGAAGAGAGTGCAGTTGTCAAACGATACAACGTTTGCTTCTACAACTACGTTACCCGTTTTGTGGCCGATTTGATGGAAATTGAAGAGTTTTCCAGTGGGCTGACACAATTGCGAACATTTGTTCGTTATATGAAACAAAATTCGGATATGTATAGCAAATTTAGa/a
Amino_acid_changePNEEICKLVEESAVVKRYNVCFYNYVTRFVADLMEIEEFSSGLTQLRTFVRYMKQNSDMYSKFR/X
Interactor (64)
GeneticsInterpolated_map_positionX22.945
Mapping_dataIn_2_point4457
4458
7082
In_multi_point (19)
In_pos_neg_data4461
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Remark13% of fertile animals (n=32) exhibited an egg laying defect.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000099Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
RemarkThe lin-15(n765) mutation resulted in 20% of animals with the '0 P11.p' phenotype (P11 adopts a P12 fate). No animals exhibited the '2 P11.p' phenotype (P12 adopts a P11 fate).Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
PenetranceIncompletePaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004410PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBbt:0004409PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0000137Paper_evidenceWBPaper00032289
Curator_confirmedWBPerson712
Remarklin-15A transcripts were reduced >10-fold as assayed by qRT-PCR (data not shown).Paper_evidenceWBPaper00032289
Curator_confirmedWBPerson712
WBPhenotype:0000218Paper_evidenceWBPaper00026863
WBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson712
WBPerson2987
RemarkOn average 5.82 VCPs (n=24 animals) are induced to adopt a vulval cell fate, which is increased compared to wild type (3/6 VPCs induced, n=29). VPCs and fate adoption were scored by Nomarski optics.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
The lin-15(n765) mutation resulted in more than the expected number of induced vulval precursor cells (4.86 on average instead of 3.0 in wild type)Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
lin-15(n765) mutant animals exhibited an average of 5.37 induced vulval precursor cells (Table I), as opposed to 3.0 in wild typePaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007809PATO:0000460Paper_evidenceWBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson2987
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown at 18.2 degrees CelsiusPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Temperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
18.2Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
WBPhenotype:0000688Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Remark3% animals produced progeny (n=41).Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000700Paper_evidenceWBPaper00000762
WBPaper00026863
WBPaper00032309
WBPaper00005344
WBPaper00005255
WBPaper00006388
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
WBPerson2987
Remark2 or 3 large ventral protrusions. n765 has a temperature-dependent maternal effect ( at 20 C)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
100% animals display one or more ectopic pseudovulvae (n=343).Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
100% of animals were Muv.Paper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
wildtype at 15C, Muv at 25C, maternal effect Muv at 20CPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
95% of lin-15(n765) animals have multiple vulvaPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
Table 1Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
Table IPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
PenetranceIncomplete55% penetrantPaper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
HighPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
91% penetrantPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
CompletePaper_evidenceWBPaper00032309
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006748PATO:0000460Paper_evidenceWBPaper00005344
WBPaper00006388
Curator_confirmedWBPerson2987
Life_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00000762
WBPaper00026863
Curator_confirmedWBPerson2021
WBPerson712
25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
MaternalWith_maternal_effectPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals raised at 17.5 degrees CelsiusPaper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
Animals were grown at 18.2 degrees CelsiusPaper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Temperature20, 25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
17.5Paper_evidenceWBPaper00005255
Curator_confirmedWBPerson2987
18.2Paper_evidenceWBPaper00006388
Curator_confirmedWBPerson2987
Genotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
WBPhenotype:0001258Paper_evidenceWBPaper00027135
Curator_confirmedWBPerson557
WBPhenotype:0001414Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RemarkHemizygous n765 males do not mate at the restricted temperaturePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
PenetranceCompletePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_assayTemperature25Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Genotypehim-5(e1467)Paper_evidenceWBPaper00000762
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000698Paper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Remark0% animals (n=24) are aberrant in induction of VPCs as scored by Nomarski optics.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Reference (26)
RemarkManually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00023498 WBGene00003004 Genomic_neighbourhood
MethodDeletion_and_insertion_allele