WormBase Tree Display for Gene: WBGene00003040

WBGene00003040 SMap: S_parent: Sequence: T12F5
  Identity: Version: 1
    Name: CGC_name: lin-59 Person_evidence: WBPerson261
      Sequence_name: T12F5.4
      Molecular_name: T12F5.4
        T12F5.4.1
        CE13601
      Other_name: CELE_T12F5.4 Accession_evidence: NDB BX284601
      Public_name: lin-59
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Allele (110)
    Legacy_information: [Chamberlin HM] sa489 males have abnormal tail development, with altered F and U cell lineages. F and U also abnormal in hermaphrodite.
    Strain: WBStrain00022835
      WBStrain00029537
      WBStrain00005831
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (40)
    Paralog (19)
    Structured_description: Concise_description: lin-59 encodes a SET domain-containing protein that is most closely related to the ASH1 group of histone-lysine N-methyltransferases; lin-59 was originally identified in screens for mutations that disrupt male tail development and subsequently was shown to be an essential gene required for development and fate specification of a number of different cells types, including those of the male tail, male and hermaphrodite hindgut, and egg-laying system; lin-59 has been shown to positively regulate expression of at least four genes: cdh-3, egl-5, mab-5, and nac-2; a lin-59::gfp reporter fusion is first expressed during the proliferative stage of embryonic development and expression continues, in most cells, throughout larval development and adulthood. Paper_evidence: WBPaper00003719
            WBPaper00003938
          Curator_confirmed: WBPerson1843
          Date_last_updated: 27 Mar 2008 00:00:00
      Automated_description: Predicted to enable histone H3K36 methyltransferase activity. Involved in several processes, including ectodermal cell fate specification; egg-laying behavior; and nematode male tail tip morphogenesis. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in hypodermis; intestine; and muscle cell. Used to study leukemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Is an ortholog of human ASH1L (ASH1 like histone lysine methyltransferase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1240 Homo sapiens Paper_evidence: WBPaper00032952
          Curator_confirmed: WBPerson38202
          Date_last_updated: 13 Jun 2018 00:00:00
    Potential_model: DOID:0080231 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19088)
  Models_disease_asserted: WBDOannot00000546
  Molecular_info: Corresponding_CDS: T12F5.4
    Corresponding_transcript: T12F5.4.1
    Other_sequence (20)
    Associated_feature (15)
    Transcription_factor: WBTranscriptionFactor000311
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr658
      Expr14359
      Expr1025648
      Expr1031425
      Expr1156808
      Expr2013195
      Expr2031427
    Drives_construct: WBCnstr00012479
      WBCnstr00036267
    Construct_product: WBCnstr00036267
    Microarray_results (18)
    Expression_cluster (131)
    Interaction: WBInteraction000003301
      WBInteraction000003302
      WBInteraction000003303
      WBInteraction000006210
      WBInteraction000006364
      WBInteraction000028712
      WBInteraction000028862
      WBInteraction000030030
      WBInteraction000032735
      WBInteraction000032954
      WBInteraction000033816
      WBInteraction000034175
      WBInteraction000034924
      WBInteraction000035372
      WBInteraction000035373
      WBInteraction000035504
      WBInteraction000035873
      WBInteraction000036760
      WBInteraction000039710
      WBInteraction000039711
      WBInteraction000039712
      WBInteraction000039713
      WBInteraction000039714
      WBInteraction000040439
      WBInteraction000052648
      WBInteraction000052933
      WBInteraction000110090
      WBInteraction000121781
      WBInteraction000126578
      WBInteraction000126834
      WBInteraction000127062
      WBInteraction000137605
      WBInteraction000143139
      WBInteraction000145290
      WBInteraction000147234
      WBInteraction000149172
      WBInteraction000150547
      WBInteraction000163069
      WBInteraction000163070
      WBInteraction000166024
      WBInteraction000166034
      WBInteraction000170631
      WBInteraction000172562
      WBInteraction000179675
      WBInteraction000181795
      WBInteraction000190658
      WBInteraction000190993
      WBInteraction000192585
      WBInteraction000195403
      WBInteraction000195737
      WBInteraction000195845
      WBInteraction000196165
      WBInteraction000197113
      WBInteraction000201559
      WBInteraction000206137
      WBInteraction000211242
      WBInteraction000211950
      WBInteraction000223214
      WBInteraction000224466
      WBInteraction000231267
      WBInteraction000237860
      WBInteraction000245917
      WBInteraction000246586
      WBInteraction000250538
      WBInteraction000257772
      WBInteraction000264326
      WBInteraction000265933
      WBInteraction000267085
      WBInteraction000270602
      WBInteraction000273831
      WBInteraction000279704
      WBInteraction000284224
      WBInteraction000286243
      WBInteraction000289706
      WBInteraction000291300
      WBInteraction000292117
      WBInteraction000293154
      WBInteraction000293802
      WBInteraction000300660
      WBInteraction000310604
      WBInteraction000312879
      WBInteraction000316305
      WBInteraction000322340
      WBInteraction000322736
      WBInteraction000325531
      WBInteraction000342797
      WBInteraction000344554
      WBInteraction000346464
      WBInteraction000353188
      WBInteraction000356429
      WBInteraction000356756
      WBInteraction000367493
      WBInteraction000371233
      WBInteraction000372332
      WBInteraction000375005
      WBInteraction000378594
      WBInteraction000381761
      WBInteraction000386851
      WBInteraction000387647
      WBInteraction000388558
      WBInteraction000389404
      WBInteraction000390641
      WBInteraction000391078
      WBInteraction000392616
      WBInteraction000399232
      WBInteraction000406319
      WBInteraction000409405
      WBInteraction000415859
      WBInteraction000424466
      WBInteraction000424548
      WBInteraction000434341
      WBInteraction000436141
      WBInteraction000436944
      WBInteraction000444097
      WBInteraction000444268
      WBInteraction000447408
      WBInteraction000456553
      WBInteraction000462221
      WBInteraction000500193
      WBInteraction000500194
      WBInteraction000500195
      WBInteraction000503925
      WBInteraction000527370
      WBInteraction000527434
      WBInteraction000543527
      WBInteraction000554700
  Map_info: Map: I Position: -2.83104 Error: 0.022529
    Well_ordered
    Positive: Inside_rearr: qDf3
      Positive_clone: T12F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3669
        3670
        3671
        3672
        3782
        4354
        4429
      Pos_neg_data: 10214
  Reference (22)
  Method: Gene