| WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lon-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | C39E6.1 |
| | | Molecular_name | C39E6.1 |
| | | | C39E6.1.1 |
| | | | CE35426 |
| | | Other_name | CELE_C39E6.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lon-2 |
| | DB_info | Database | AceView | gene | XF356 |
| | | | WormQTL | gene | WBGene00003056 |
| | | | WormFlux | gene | WBGene00003056 |
| | | | NDB | locus_tag | CELE_C39E6.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530 |
| | | | | family | PTHR10822 |
| | | | NCBI | gene | 180750 |
| | | | RefSeq | protein | NM_076411.8 |
| | | | TREEFAM | TREEFAM_ID | TF353541 |
| | | | TrEMBL | UniProtAcc | Q18530 |
| | | | UniProt_GCRP | UniProtAcc | Q18530 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lon |
| | Reference_allele | WBVar00143398 |
| | Allele (213) |
| | Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). |
| | | [C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] |
| | Strain (224) |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (25) |
| | Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 24 Jan 2007 00:00:00 |
| | | Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C39E6.1 |
| | Corresponding_CDS_history | C39E6.1:wp107 |
| | Corresponding_transcript | C39E6.1.1 |
| | Other_sequence | CRC07010_1 |
| | | CR09868 |
| | | CGC00490_1 |
| | | CBC13859_1 |
| | | CJC03031_1 |
| | | CRC04307_1 |
| | Associated_feature (15) |
| Experimental_info | RNAi_result (23) |
| | Expr_pattern | Expr4651 |
| | | Expr4652 |
| | | Expr12191 |
| | | Expr1011265 |
| | | Expr1031435 |
| | | Expr1146202 |
| | | Expr2013244 |
| | | Expr2031475 |
| | Drives_construct | WBCnstr00012150 |
| | | WBCnstr00012151 |
| | | WBCnstr00021097 |
| | | WBCnstr00021479 |
| | | WBCnstr00036259 |
| | Construct_product | WBCnstr00012151 |
| | | WBCnstr00021471 |
| | | WBCnstr00021474 |
| | | WBCnstr00021479 |
| | | WBCnstr00036259 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057006:DietaryRestriction_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061340:ADE |
| | | WBPaper00061340:AFD |
| | | WBPaper00061340:AIN |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:g1A |
| | | WBPaper00061340:g1A_g1P |
| | | WBPaper00061340:g1A_parent |
| | | WBPaper00061340:g2 |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:MC |
| | | WBPaper00061340:Neuroblast_I6_M5 |
| | | WBPaper00061340:Neuroblast_M2_M3 |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parent_of_g1P_I3 |
| | | WBPaper00061340:Parent_of_MI_pm1DR |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:Pharyngeal_neuron |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:RMED |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061651:I6_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:23_0 |
| | | WBPaper00065841:36_0 |
| | | WBPaper00065841:36_3 |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:60_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:135_0 |
| | | WBPaper00065841:145_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_downregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_3 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00036286:Pattern_D |
| | | WBPaper00037611:GLD-2-associated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (24) |
| Map_info | Map | X | Position | -6.74013 | Error | 0.007834 |
| | Well_ordered |
| | Positive | Inside_rearr | mnDp30 |
| | | | yDp4 |
| | | Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | F43C9 |
| | Negative | Outside_rearr | mcDf2 |
| | Mapping_data | 2_point (57) |
| | | Multi_point (150) |
| | | Pos_neg_data | 935 |
| | | | 1859 |
| | | | 1888 |
| | | | 1912 |
| | | | 1928 |
| | | | 1944 |
| | | | 1960 |
| | | | 1976 |
| | | | 1992 |
| | | | 2019 |
| | | | 2040 |
| | | | 2051 |
| | | | 2058 |
| | | | 2174 |
| | | | 2175 |
| | | | 2178 |
| | | | 2362 |
| | | | 5453 |
| | | | 5834 |
| | | | 4564 |
| | | | 8420 |
| | | | 8422 |
| | | | 8429 |
| | | | 8433 |
| | | | 8441 |
| | | | 8446 |
| | | | 8450 |
| | | | 8456 |
| | | | 8475 |
| | | | 10694 |
| | | | 10695 |
| | Landmark_gene |
| Reference (155) |
| Remark | sequence wsa incorrectly given as F43C9.3 |
| Method | Gene |
