WormBase Tree Display for Gene: WBGene00003136

WBGene00003136 SMap: S_parent: Sequence: C09H6
  Identity: Version: 2
    Name: CGC_name: mau-2 Person_evidence: WBPerson247
      Sequence_name: C09H6.3
      Molecular_name: C09H6.3
        C09H6.3.1
        CE15611
      Other_name: CELE_C09H6.3 Accession_evidence: NDB BX284601
      Public_name: mau-2
    DB_info: Database: AceView gene 1I705
        WormQTL gene WBGene00003136
        WormFlux gene WBGene00003136
        NDB locus_tag CELE_C09H6.3
        Panther gene CAEEL|WormBase=WBGene00003136|UniProtKB=O17581
          family PTHR21394
        NCBI gene 172598
        RefSeq protein NM_059827.7
        SwissProt UniProtAcc O17581
        TREEFAM TREEFAM_ID TF105981
        UniProt_GCRP UniProtAcc O17581
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 15 Feb 2005 15:39:39 WBPerson2970 Event: Acquires_merge: WBGene00007498
      Acquires_merge: WBGene00007498
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mau
    Allele (96)
    Legacy_information: [Hekimi S] kinky Unc, Egl, neuroanatomical defects; short excretory canals; Egl; some lethality; full zygotic rescue, almost complete maternal rescue, no maternal rescue of Egl. OA2 (qm5, qm40). [MQ]
      [C.elegansII] qm4 : kinky Unc, Egl, neuroanatomical defects; short excretory canals; Egl; some lethality; full zygotic rescue, almost complete maternal rescue, no maternal rescue of Egl. OA2 (qm5, qm40). [MQ]
    Strain: WBStrain00026635
      WBStrain00026668
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (38)
    Structured_description: Concise_description: mau-2 encodes an ortholog of budding yeast Scc4p, Drosophila CG4203, andhuman KIAA0892; MAU-2 is required (with PQN-85 and SCC-3) for normalmitotic chromosome segregation, and for cellular (e.g., neuronal) oraxonal migration; MAU-2 is required for migration both embryonically andpostembryonically, along both dorsoventral and longitudinal body axes;MAU-2 guides the axonal projection of AVM (and probably other neurons)by some cell-autonomous mechanism independent of SLT-1; MAU-2 is alsorequired for normal larval development, locomotion, excretory canals andosmoregulation, phasmid morphology, and egg-laying; the primarysequences of MAU-2 and its Scc4-like orthologs are composed oftetratricopeptide repeats, and are highly divergent between yeast andmetazoa; MAU-2 is expressed ubiquitously in embryos during lategastrulation, subsequently becoming restricted to neurons; mau-2transcripts are abundant in oocytes, and maternal transcripts alone cansupport normal MAU-2 protein synthesis through the L3 larval stage (butnot in L4 larvae or adults); MAU-2's N-terminal 371 residues of MAU-2are its most conserved domain, and are sufficient to transgenicallyrescue mau-2 mutants; despite its behavioral phenotype, MAU-2 is thoughtto act early in development, since the uncoordinated phenotype of mau-2mutants is maternal; while the uncoordinated phenotype of mau-2 mutantscan be rescued either maternally or zygotically, the egg-layingphenotype of mau-2 mutants is purely zygotic; partially penetrant mau-2dye-filling phenotypes occur on one side of the body, suggesting thatMAU-2 acts on a whole side of an embryo at a time; while mau-2(RNAi) hasno obvious early embryonic phenotype, joint mau-2/scc-3(RNAi) grosslyderanges chromosomal segregation in early embryos, and mau-2(RNAi)enhances the lagging of anaphase chromosomes induced by pqn-85(RNAi). Paper_evidence: WBPaper00002340
            WBPaper00002968
            WBPaper00024594
            WBPaper00027710
          Curator_confirmed: WBPerson567
          Date_last_updated: 24 Apr 2007 00:00:00
      Automated_description: Predicted to enable double-stranded DNA binding activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and egg-laying behavior. Located in axon and cytoplasm. Expressed in nervous system; oocyte; and vulval muscle. Is an ortholog of human MAU2 (MAU2 sister chromatid cohesion factor). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C09H6.3
    Corresponding_transcript: C09H6.3.1
    Other_sequence: CR00998
      CJC10824_1
      ES741290.1
      CRC03374_1
      HBC21988_1
      CBC17050_1
    Associated_feature: WBsf643511
      WBsf656608
      WBsf984349
      WBsf984350
      WBsf218122
      WBsf218123
  Experimental_info: RNAi_result: WBRNAi00028762 Inferred_automatically: RNAi_primary
      WBRNAi00040272 Inferred_automatically: RNAi_primary
      WBRNAi00065886 Inferred_automatically: RNAi_primary
      WBRNAi00065882 Inferred_automatically: RNAi_primary
      WBRNAi00065885 Inferred_automatically: RNAi_primary
      WBRNAi00061479 Inferred_automatically: RNAi_primary
      WBRNAi00002926 Inferred_automatically: RNAi_primary
      WBRNAi00116844 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3158
      Expr3159
      Expr3160
      Expr1015173
      Expr1031480
      Expr1144341
      Expr2013425
      Expr2031659
    Drives_construct: WBCnstr00036220
    Construct_product: WBCnstr00036220
    Antibody: WBAntibody00000827
    Microarray_results (19)
    Expression_cluster (110)
    Interaction (37)
  Map_info: Map: I Position: 2.56119 Error: 0.005309
    Well_ordered
    Positive: Inside_rearr: nDf24
      Positive_clone: C09H6 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: nDf23
    Mapping_data: Multi_point: 3610
      Pos_neg_data: 9306
        9307
  Reference (18)
  Method: Gene