WormBase Tree Display for Gene: WBGene00003149
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| WBGene00003149 | SMap | S_parent | Sequence | T04C10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mbk-1 | Person_evidence | WBPerson1138 | |||||
| Sequence_name | T04C10.1 | ||||||||
| Molecular_name | T04C10.1 | ||||||||
| T04C10.1.1 | |||||||||
| CE33442 | |||||||||
| Other_name | CELE_T04C10.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mbk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mbk | ||||||||
| Allele (85) | |||||||||
| Strain | WBStrain00007137 | ||||||||
| WBStrain00031416 | |||||||||
| WBStrain00007134 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00001994 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003150 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016465 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00016464 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WBGene00006517 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013727 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00185089 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mbk-1 encodes a putative dual-specificity kinase (predicted to have both serine/threonine and tyrosine substrates) that is orthologous to Drosophila MINIBRAIN and mammalian DYRK1A/MnbK and that has a glutamine/asparagine-rich domain; MBK-1 is found in most or all nuclei, is dispensable for viability, and perturbs olfaction in AWC when overexpressed. | Paper_evidence | WBPaper00005068 | |||||
| WBPaper00012788 | |||||||||
| WBPaper00012830 | |||||||||
| WBPaper00012882 | |||||||||
| WBPaper00012897 | |||||||||
| WBPaper00013003 | |||||||||
| WBPaper00017919 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in several structures, including anterior gonad arm. Used to study Down syndrome and intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal obesity-metabolic syndrome 3; and autosomal dominant intellectual developmental disorder 7. Is an ortholog of human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00005756 | ||||
| Accession_evidence | OMIM | 614104 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Apr 2013 00:00:00 | ||||||||
| DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005756 | ||||||
| WBPaper00062322 | |||||||||
| Accession_evidence | OMIM | 190685 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Aug 2022 00:00:00 | ||||||||
| Potential_model | DOID:0060612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3092) | |||||
| DOID:0070037 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3091) | ||||||
| DOID:14250 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3091) | ||||||
| DOID:0060041 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3091) | ||||||
| DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3091) | ||||||
| Disease_relevance | Human DYRK1A gene encodes a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which includes Drosophila minibrain, and is a conserved gene located in the Down Syndrome critical region (DSCR) of chromosome 21; Down syndrome is the most frequent chromosomal abnormality in human infants, where DYRK1A overexpression is observed, and is characterized by a set of facial and physical features, heart defects, abnormalities in the immune and endocrine systems, spatial memory defecits and difficulty in converting short-term to long-term memories; in elegans, the genes mbk-1 and mbk-2 have close homology with human DYRK1A and hpk-1 is more distantly related; while mutants deficient for mbk-1 seem to be normal, overexpression of mbk-1 causes behavioral defects in chemotaxis, acting in mature, fully differentiated neurons; however, this defect could be reversed by bringing back normal mbk-1 levels, which provided the first hint that DYRK1-induced defects could be reversed; mbk-2(pk1427) homozygous animals display 100% penetrant maternal-effect embryonic lethality, making it difficult to test redundant function with mbk-1. | Homo sapiens | Paper_evidence | WBPaper00005756 | |||||
| WBPaper00042136 | |||||||||
| Accession_evidence | OMIM | 190685 | |||||||
| 614104 | |||||||||
| 600855 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Jun 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000128 | ||||||||
| WBDOannot00000311 | |||||||||
| Models_disease_asserted | WBDOannot00001310 | ||||||||
| Molecular_info | Corresponding_CDS | T04C10.1 | |||||||
| Corresponding_CDS_history | T04C10.1:wp95 | ||||||||
| Corresponding_transcript | T04C10.1.1 | ||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097950 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00098498 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00052361 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018129 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00033252 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066576 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066670 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108300 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2387 | ||||||||
| Expr13126 | |||||||||
| Expr1011898 | |||||||||
| Expr1031485 | |||||||||
| Expr1155990 | |||||||||
| Expr2013431 | |||||||||
| Expr2031665 | |||||||||
| Drives_construct | WBCnstr00000365 | ||||||||
| WBCnstr00000366 | |||||||||
| WBCnstr00036216 | |||||||||
| Construct_product | WBCnstr00036216 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (207) | |||||||||
| Anatomy_function | WBbtf0197 | ||||||||
| Map_info | Map | X | Position | 21.4092 | Error | 0.007411 | |||
| Positive | Positive_clone | T04C10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4483 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Sequence connection from [Raich WB]. 02/06/12 krb. | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
