WormBase Tree Display for Gene: WBGene00003165
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| WBGene00003165 | SMap | S_parent | Sequence | T07H8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mec-1 | Person_evidence | WBPerson95 | |||||
| Sequence_name | T07H8.4 | ||||||||
| Molecular_name (31) | |||||||||
| Other_name | che-4 | ||||||||
| CELE_T07H8.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | mec-1 | ||||||||
| DB_info | Database | AceView | gene | 5H445 | |||||
| WormQTL | gene | WBGene00003165 | |||||||
| WormFlux | gene | WBGene00003165 | |||||||
| NDB | locus_tag | CELE_T07H8.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003165|UniProtKB=Q5ZR42 | |||||||
| family | PTHR10083 | ||||||||
| NCBI | gene | 188259 | |||||||
| RefSeq | protein | NM_001380684.1 | |||||||
| NM_001380682.1 | |||||||||
| NM_001028949.3 | |||||||||
| NM_001028946.6 | |||||||||
| NM_001380683.1 | |||||||||
| NM_001380680.1 | |||||||||
| NM_001380681.1 | |||||||||
| NM_171477.7 | |||||||||
| NM_001028947.3 | |||||||||
| NM_001392539.1 | |||||||||
| TREEFAM | TREEFAM_ID | TF316874 | |||||||
| TrEMBL | UniProtAcc | Q5ZR42 | |||||||
| Q5ZR36 | |||||||||
| H2KZ68 | |||||||||
| Q5ZR40 | |||||||||
| A5A8R1 | |||||||||
| Q5ZR35 | |||||||||
| A5A8R2 | |||||||||
| Q5ZR39 | |||||||||
| H2KZ67 | |||||||||
| Q5ZR41 | |||||||||
| UniProt_GCRP | UniProtAcc | Q5ZR42 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Reference_allele | WBVar00143718 | ||||||||
| Allele (159) | |||||||||
| Legacy_information | See also e1066, e1292, e1336, e1737, e1738 | ||||||||
| [C.elegansII] e1066 : (pka che-4) touch insensitive; lethargic; microtubule cells lack extracellular mantle often displaced; some amphidial neurons also displaced, defective fasciculation. ES2 ME2. OA>50: e1292, e1336, u39amb etc. Most alleles resemble e1066 but may lack amphidial neuron displacement. [Perkins et al. 1986] | |||||||||
| Strain | WBStrain00004236 | ||||||||
| WBStrain00004291 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (36) | |||||||||
| Paralog (28) | |||||||||
| Structured_description | Concise_description | mec-1 encodes proteins with multiple disulfide-linked EGF and Kunitz domains; MEC-1 activity is required for normal mechanosensory behavior, and specifically for: 1) localization of the touch receptor degenerin channel complex, 2) accumulation of MEC-5/collagen into the extracellular matrix surrounding touch receptor neurons, and 3) attachment of touch receptor processes to the body wall; mec-1 promoter-GFP fusions indicate that, in addition to the six touch receptors, mec-1 can be expressed in many lateral neurons, the PVT interneuron, and the intestinal muscle; mec-1 expression in the touch receptors is, however, sufficient to rescue touch sensitivity in mec-1 mutant animals; MEC-1 appears to be an extracellular protein that: 1) binds to touch receptor processes uniformly and in a punctate pattern and 2) colocalizes with MEC-5 and degenerin channel puncta on these processes; while localization of MEC-1 into puncta requires the activity of mec-5 and mec-9, uniform MEC-1 localization requires the activity of him-4; in addition, proper organization and distribution of MEC-1, MEC-5, and the degenerin channel complex puncta appears to be regulated by interactions with adjacent epidermal tissue. | Paper_evidence | WBPaper00000502 | |||||
| WBPaper00024622 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Sep 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable serine-type endopeptidase inhibitor activity. Involved in detection of mechanical stimulus involved in sensory perception of touch; extracellular structure organization; and mechanosensory behavior. Predicted to be located in extracellular space. Expressed in PVT; cholinergic neurons; intestinal muscle; and touch receptor neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07H8.4a | |||||||
| T07H8.4b | |||||||||
| T07H8.4c | |||||||||
| T07H8.4d | |||||||||
| T07H8.4e | |||||||||
| T07H8.4f | |||||||||
| T07H8.4g | |||||||||
| T07H8.4h | |||||||||
| T07H8.4i | |||||||||
| T07H8.4j | |||||||||
| Corresponding_CDS_history | T07H8.4a:wp131 | ||||||||
| T07H8.4b:wp109 | |||||||||
| T07H8.4b:wp131 | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence (56) | |||||||||
| Associated_feature | WBsf231924 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00103515 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052813 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018412 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089153 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3463 | ||||||||
| Expr1026744 | |||||||||
| Expr1031500 | |||||||||
| Expr1156414 | |||||||||
| Expr2013495 | |||||||||
| Expr2031729 | |||||||||
| Drives_construct | WBCnstr00011403 | ||||||||
| WBCnstr00036205 | |||||||||
| Construct_product | WBCnstr00036205 | ||||||||
| Microarray_results (130) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (45) | |||||||||
| WBProcess | WBbiopr:00000002 | ||||||||
| Map_info | Map | V | Position | 0.482741 | Error | 0.000385 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf30 | |||||||
| nDf32 | |||||||||
| Positive_clone | T07H8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 127 | |||||||
| Multi_point | 139 | ||||||||
| 140 | |||||||||
| 1160 | |||||||||
| 5340 | |||||||||
| 5681 | |||||||||
| Pos_neg_data (11) | |||||||||
| Reference (72) | |||||||||
| Remark | Sequence connection from [Emtage L, Gu GQ, Chalfie M] | ||||||||
| Method | Gene |
