WormBase Tree Display for Gene: WBGene00003172

WBGene00003172 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: mec-8 Person_evidence: WBPerson95
      Sequence_name: F46A9.6
      Molecular_name: F46A9.6
        F46A9.6.1
        CE08260
        F46A9.6.2
      Other_name: CELE_F46A9.6 Accession_evidence: NDB BX284601
      Public_name: mec-8
    DB_info: Database: AceView gene 1K18
        WormQTL gene WBGene00003172
        WormFlux gene WBGene00003172
        NDB locus_tag CELE_F46A9.6
        Panther gene CAEEL|WormBase=WBGene00003172|UniProtKB=G5ECJ4
          family PTHR10501
        NCBI gene 172771
        RefSeq protein NM_060107.7
        TREEFAM TREEFAM_ID TF351070
        TrEMBL UniProtAcc G5ECJ4
        UniProt_GCRP UniProtAcc G5ECJ4
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (12)
  Molecular_info: Corresponding_CDS: F46A9.6
    Corresponding_transcript: F46A9.6.1
      F46A9.6.2
    Other_sequence (24)
    Associated_feature (31)
    Gene_product_binds: WBsf047657
      WBsf047658
  Experimental_info: RNAi_result (14)
    Expr_pattern (12)
    Drives_construct: WBCnstr00002454
      WBCnstr00006517
      WBCnstr00010759
      WBCnstr00036198
      WBCnstr00041290
      WBCnstr00042667
    Construct_product: WBCnstr00006517
      WBCnstr00010759
      WBCnstr00016049
      WBCnstr00036198
      WBCnstr00041290
      WBCnstr00042667
    Regulate_expr_cluster: WBPaper00062197:mec-8_downregulated
      WBPaper00062197:mec-8_downregulated_TRN
      WBPaper00062197:mec-8_upregulated
      WBPaper00062197:mec-8_upregulated_TRN
    Antibody: WBAntibody00000576
    Microarray_results (26)
    Expression_cluster: WBPaper00028788:MPK-1_Response_Weak
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1678
      WBPaper00032031:DConiospora_downregulated_cDNA_12h
      WBPaper00032031:DConiospora_downregulated_cDNA_24h
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040420:FLP_enriched
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00046805:csr-1(RNAi)_downregulated_Set1
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AFD
      WBPaper00061340:ALM_BDU
      WBPaper00061340:ALM_PLM
      WBPaper00061340:AMso
      WBPaper00061340:Anterior_arcade_cell
      WBPaper00061340:F_U
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:Glia
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:K_Kprime
      WBPaper00061340:PLM
      WBPaper00061340:P_cell
      WBPaper00061340:T
      WBPaper00061340:Y
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061651:ALM_enriched
      WBPaper00061651:PLM_enriched
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:20_0
      WBPaper00065841:20_2
      WBPaper00065841:44_0
      WBPaper00065841:62_0
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      cgc4386_cluster_6_4
      cgc4489_group_14
      WBPaper00025032:cluster_7
      WBPaper00025032:cluster_17
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034739:N2moreDR1350
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037695:CC_3-day
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_3h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045673:colistin_upregulated
      [cgc5767]:cluster_4
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(101_min)
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(83_min)
      [cgc6390]:Cluster_A
    Interaction (185)
  Map_info: Map: I Position: 3.76436 Error: 0.0003
    Well_ordered
    Positive: Positive_clone: C17E4
        C34A2
        F46A9 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 27
        5741
      Multi_point (14)
      Pos_neg_data (18)
  Reference (119)
  Remark: [Lundquist EA] I'm quite certain that these polymorphisms are defects in the mec-8 gene. u456 and rh170 are small deletions of the same 2.5kb HIII fragment, u391 is a complex rearrangement that has a breakpoint in the same 2.5kb HIII fragment, and mn472 is a Tc1 insertion into the same 2.5kb HIII fragment. Furthermore, the area of these cosmids on the physical map is in good agreement with the genetic map position of mec-8. Rescue is hopefully on the way.
  Method: Gene