WormBase Tree Display for Gene: WBGene00003230
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| WBGene00003230 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | W02A2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mex-5 | Person_evidence | WBPerson498 | |||||
| Sequence_name | W02A2.7 | ||||||||
| Molecular_name | W02A2.7 | ||||||||
| W02A2.7.1 | |||||||||
| CE21237 | |||||||||
| Other_name | CELE_W02A2.7 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | mex-5 | ||||||||
| DB_info | Database | AceView | gene | 4O119 | |||||
| WormQTL | gene | WBGene00003230 | |||||||
| WormFlux | gene | WBGene00003230 | |||||||
| NDB | locus_tag | CELE_W02A2.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003230|UniProtKB=Q9XUB2 | |||||||
| family | PTHR12547 | ||||||||
| NCBI | gene | 178296 | |||||||
| RefSeq | protein | NM_070165.7 | |||||||
| SwissProt | UniProtAcc | Q9XUB2 | |||||||
| TREEFAM | TREEFAM_ID | TF322043 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XUB2 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mex | ||||||||
| Allele (51) | |||||||||
| Legacy_information | [Priess, J.] zu199: maternal-effect lethal mutation. Embryos produce excess intestine and pharyngeal muscle from the AB blastomere, while germ cells appear normal in most embryos by morphological criteria. | ||||||||
| Strain (15) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (30) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | mex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 activity is regulated in vivo by PLK-1 and PLK-2, which presumably bind and phosphorylate MBK-2-primed MEX-5; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon a phosphorylation/dephosphorylation cycle by the PAR-1 kinase and PP2A phosphatases including LET-92, that regulate MEX-5's association with slow- or fast-diffusing RNA-containing complexes. | Paper_evidence | WBPaper00004112 | |||||
| WBPaper00005160 | |||||||||
| WBPaper00005735 | |||||||||
| WBPaper00005930 | |||||||||
| WBPaper00006004 | |||||||||
| WBPaper00031434 | |||||||||
| WBPaper00040201 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Oct 2011 00:00:00 | ||||||||
| Automated_description | Enables RNA binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule and centrosome. Expressed in germ line; head muscle; head neurons; intestine; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02A2.7 | |||||||
| Corresponding_transcript | W02A2.7.1 | ||||||||
| Other_sequence (40) | |||||||||
| Associated_feature | WBsf977016 | ||||||||
| WBsf977017 | |||||||||
| WBsf977018 | |||||||||
| WBsf977019 | |||||||||
| WBsf977020 | |||||||||
| WBsf977021 | |||||||||
| WBsf977022 | |||||||||
| WBsf978625 | |||||||||
| WBsf229424 | |||||||||
| WBsf229425 | |||||||||
| Gene_product_binds | WBsf034344 | ||||||||
| WBsf034345 | |||||||||
| WBsf034346 | |||||||||
| WBsf034347 | |||||||||
| WBsf034348 | |||||||||
| WBsf034349 | |||||||||
| WBsf034350 | |||||||||
| WBsf034351 | |||||||||
| WBsf034352 | |||||||||
| Transcription_factor | WBTranscriptionFactor000124 | ||||||||
| Experimental_info | RNAi_result (42) | ||||||||
| Expr_pattern | Expr2463 | ||||||||
| Expr4082 | |||||||||
| Expr7693 | |||||||||
| Expr1027384 | |||||||||
| Expr1031527 | |||||||||
| Expr1158094 | |||||||||
| Expr2013543 | |||||||||
| Expr2031777 | |||||||||
| Drives_construct (165) | |||||||||
| Construct_product (27) | |||||||||
| Antibody | WBAntibody00000279 | ||||||||
| WBAntibody00000903 | |||||||||
| WBAntibody00001692 | |||||||||
| WBAntibody00002283 | |||||||||
| WBAntibody00002284 | |||||||||
| WBAntibody00002285 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (219) | |||||||||
| Interaction (311) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | IV | Position | 8.5394 | Error | 0.011779 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | W02A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3912 | |||||||
| 3913 | |||||||||
| 4914 | |||||||||
| Reference (109) | |||||||||
| Method | Gene |
