WormBase Tree Display for Gene: WBGene00003247
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| WBGene00003247 | SMap | S_parent | Sequence | ZC504 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mig-15 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZC504.4 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | qid-7 | Person_evidence | WBPerson1157 | ||||||
| qid-8 | Person_evidence | WBPerson1157 | |||||||
| CELE_ZC504.4 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mig-15 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Nov 2014 12:25:34 | WBPerson2970 | Event | Acquires_merge | WBGene00004262 | ||||
| Name_change | Other_name | qid-7 | |||||||
| 3 | 04 Nov 2014 12:27:29 | WBPerson2970 | Event | Acquires_merge | WBGene00004263 | ||||
| Name_change | Other_name | qid-8 | |||||||
| Acquires_merge | WBGene00004263 | ||||||||
| WBGene00004262 | |||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (101) | |||||||||
| Legacy_information | [Hedgecock EM] QL migration resembles QR. Pleiotropic defects in hypodermis. | ||||||||
| [C.elegansII] rh148 : QL migration resembles QR. Pleiotropic defects in hypodermis. [CF] | |||||||||
| Strain | WBStrain00024147 | ||||||||
| WBStrain00024148 | |||||||||
| WBStrain00028841 | |||||||||
| WBStrain00028845 | |||||||||
| WBStrain00028859 | |||||||||
| WBStrain00004868 | |||||||||
| WBStrain00004869 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (41) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | mig-15 encodes the C. elegans ortholog of vertebrate Nck-interacting kinase (NIK) which belongs to the STE20/germinal center kinase (GCK) family; MIG-15 is required for normal axon pathfinding, and to inhibit premature branching of commissures; RNAi of mig-15 and pat-3, which encodes a beta1A integrins, results in similar axonal defects, and mutations in ina-1, which encodes an alpha integrin chain, enhances the commissural phenotype of mig-15 mutations; MIG-15 also regulates multiple aspects Q cell behavior, including initial Q cell polarization (direction of lamellipodium extension) and maintenance of that polarity, as well as migration of the Q cells and their descendants; genetic mosaic analyses indicate that MIG-15 likely acts cell autonomously at least in AQR and PQR to regulate their migration; MIG-15 physically interacts with the cytoplasmic domain of the beta1A integrin, PAT-3; loss of mig-15 results in increased synapse number and synaptic tiling defect in DA neurons. | Paper_evidence | WBPaper00005218 | |||||
| WBPaper00032247 | |||||||||
| WBPaper00026842 | |||||||||
| WBPaper00006110 | |||||||||
| WBPaper00054962 | |||||||||
| Person_evidence | WBPerson3718 | ||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 10 Oct 2018 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | |||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
| DOID:0081216 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:30765) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
| DOID:2043 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6866) | ||||||
| Models_disease_asserted | WBDOannot00000550 | ||||||||
| WBDOannot00000551 | |||||||||
| WBDOannot00000555 | |||||||||
| Molecular_info | Corresponding_CDS | ZC504.4a | |||||||
| ZC504.4b | |||||||||
| ZC504.4c | |||||||||
| ZC504.4d | |||||||||
| Corresponding_transcript | ZC504.4a.1 | ||||||||
| ZC504.4b.1 | |||||||||
| ZC504.4c.1 | |||||||||
| ZC504.4d.1 | |||||||||
| Other_sequence (61) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr1844 | ||||||||
| Expr8961 | |||||||||
| Expr1027934 | |||||||||
| Expr1031541 | |||||||||
| Expr1162414 | |||||||||
| Expr2013563 | |||||||||
| Expr2031796 | |||||||||
| Drives_construct | WBCnstr00010481 | ||||||||
| WBCnstr00013639 | |||||||||
| WBCnstr00036163 | |||||||||
| Construct_product | WBCnstr00010481 | ||||||||
| WBCnstr00022525 | |||||||||
| WBCnstr00036163 | |||||||||
| Microarray_results (43) | |||||||||
| Expression_cluster (104) | |||||||||
| Interaction (111) | |||||||||
| Anatomy_function | WBbtf0783 | ||||||||
| WBbtf0784 | |||||||||
| WBProcess | WBbiopr:00000082 | ||||||||
| WBbiopr:00000107 | |||||||||
| WBbiopr:00000111 | |||||||||
| Map_info | Map | X | Position | 2.19018 | Error | 0.003698 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZC504 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3293 | |||||||
| 3294 | |||||||||
| 3295 | |||||||||
| 3296 | |||||||||
| 4886 | |||||||||
| 4133 | |||||||||
| Reference (46) | |||||||||
| Method | Gene |
