mir-84 encodes a microRNA, a small non-protein coding RNA that appears to be conserved in Drosophila and humans; mir-84 is similar in sequence to the let-7 stRNA suggesting they may have the same target sites; mir-84 seems to act redundantly with other members of the let-7 family, mir-48 and mir-241 to control the L2 larval to L3 larval stage transition and larval to adult transition; an overexpression of mir-84 results in abnormal vulval and uterine morphologies; a mir-84-gfp fusion construct is expressed temporally in cells that give rise to the vulva and uterus; mir-84 is expressed starting from the L2 larval stage; mir-84 expression is promoted by lin-4.
Predicted to enable translation repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of Ras protein signal transduction; and positive regulation of development, heterochronic. Expressed in several structures, including P5.ppp; gonad; somatic gonad precursor; touch receptor neurons; and vulval precursor cell. Used to study Parkinson's disease.
mir-84 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-84 and mir-48 are underexpressed.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.