WormBase Tree Display for Gene: WBGene00003312
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WBGene00003312 | Evidence | Paper_evidence | WBPaper00004928 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0395 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001265 | |||||
Gene_class | mir | ||||||
Allele (11) | |||||||
Strain (24) | |||||||
In_cluster | LET-7 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00106255 | ||||||
00106256 | |||||||
00106257 | |||||||
00106258 | |||||||
00106259 | |||||||
Structured_description | Concise_description | mir-84 encodes a microRNA, a small non-protein coding RNA that appears to be conserved in Drosophila and humans; mir-84 is similar in sequence to the let-7 stRNA suggesting they may have the same target sites; mir-84 seems to act redundantly with other members of the let-7 family, mir-48 and mir-241 to control the L2 larval to L3 larval stage transition and larval to adult transition; an overexpression of mir-84 results in abnormal vulval and uterine morphologies; a mir-84-gfp fusion construct is expressed temporally in cells that give rise to the vulva and uterus; mir-84 is expressed starting from the L2 larval stage; mir-84 expression is promoted by lin-4. | Paper_evidence | WBPaper00004927 | |||
WBPaper00004928 | |||||||
WBPaper00019533 | |||||||
WBPaper00019534 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Feb 2005 00:00:00 | ||||||
Automated_description | Predicted to enable translation repressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of Ras protein signal transduction; and positive regulation of development, heterochronic. Expressed in several structures, including P5.ppp; gonad; somatic gonad precursor; touch receptor neurons; and vulval precursor cell. Used to study Parkinson's disease. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035654 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jan 2014 00:00:00 | ||||||
Disease_relevance | mir-84 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies in an elegans transgenic model of Parkinson''s disease, where A53T alpha-synuclein is overexpressed, indicate that elegans mir-84 and mir-48 are underexpressed. | Homo sapiens | Paper_evidence | WBPaper00035654 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jan 2014 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000267 | ||||||
Molecular_info | Corresponding_transcript | B0395.4 | |||||
B0395.4a | |||||||
B0395.4b | |||||||
Other_sequence | AJ487607 | ||||||
Associated_feature | WBsf979138 | ||||||
WBsf1008407 | |||||||
WBsf1008408 | |||||||
WBsf1024700 | |||||||
WBsf1024701 | |||||||
Experimental_info | Expr_pattern (13) | ||||||
Drives_construct | WBCnstr00000959 | ||||||
WBCnstr00000974 | |||||||
WBCnstr00000975 | |||||||
WBCnstr00000976 | |||||||
WBCnstr00005521 | |||||||
WBCnstr00011409 | |||||||
WBCnstr00015768 | |||||||
WBCnstr00015775 | |||||||
WBCnstr00017832 | |||||||
WBCnstr00021002 | |||||||
Construct_product | WBCnstr00000974 | ||||||
WBCnstr00000975 | |||||||
WBCnstr00000976 | |||||||
WBCnstr00015775 | |||||||
WBCnstr00016929 | |||||||
Expression_cluster (20) | |||||||
Interaction (62) | |||||||
WBProcess | WBbiopr:00000083 | ||||||
Map_info | Map | X | Position | 23.6761 | Error | 0.082927 | |
Positive | Positive_clone | B0395 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4658 | |||||
Pseudo_map_position | |||||||
Reference (72) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |