WormBase Tree Display for Gene: WBGene00003377
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| WBGene00003377 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C39E6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | mls-2 | Person_evidence | WBPerson959 | |||||
| Sequence_name | C39E6.4 | ||||||||
| Molecular_name | C39E6.4 | ||||||||
| C39E6.4.1 | |||||||||
| CE30891 | |||||||||
| Other_name | CELE_C39E6.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mls-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mls | ||||||||
| Allele (64) | |||||||||
| Possibly_affected_by | WBVar02157228 | ||||||||
| WBVar02157229 | |||||||||
| Legacy_information | [cc615] : Defects in M lineage fate specification, randomisation of division planes in the M lineage. Fate transformation of coelomocytes and bodywall muscles to sex myoblasts in the M lineage. Sex myoblast migration defect. | Person_evidence | WBPerson1659 | ||||||
| Strain | WBStrain00026332 | ||||||||
| WBStrain00026335 | |||||||||
| WBStrain00050587 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Concise_description | mls-2 encodes a homeodomain protein of the HMX family; during postembryonic development, MLS-2 is required for cell proliferation, cleavage orientation, and fate specification in the mesodermal M lineage; in regulating M lineage proliferation and fate specification, MLS-2 appears to act upstream of CYE-1/cyclin E and HLH-1/CeMyoD, respectively, the latter of which is not expressed in the M lineage in mls-2 mutant animals; MLS-2 is expressed in the nuclei of early proliferating undifferentiated M lineage cells (up to the 8-M stage), in a subset of head neurons, and in cells near the vulva during the L2 and L3 larval stages. | Paper_evidence | WBPaper00026712 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 01 Aug 2007 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuron differentiation involved in amphid sensory organ development; and regulation of cell differentiation. Located in nucleus. Expressed in several structures, including AB lineage cell; AWC-ON; M.dla; head; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Is an ortholog of human HMX1 (H6 family homeobox 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060482 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5017) | ||||
| Molecular_info | Corresponding_CDS | C39E6.4 | |||||||
| Corresponding_transcript | C39E6.4.1 | ||||||||
| Other_sequence | SS02421 | ||||||||
| GRC01104_1 | |||||||||
| Dviv_isotig26257 | |||||||||
| GRC05667_1 | |||||||||
| Oden_isotig28852 | |||||||||
| SSC03100_1 | |||||||||
| GR12274 | |||||||||
| Acan_isotig07401 | |||||||||
| JI172255.1 | |||||||||
| Associated_feature (11) | |||||||||
| Transcription_factor | WBTranscriptionFactor000491 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00029684 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00042212 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001129 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011782 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011781 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061153 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061154 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042211 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00011573 | ||||||||
| WBCnstr00012615 | |||||||||
| WBCnstr00013082 | |||||||||
| WBCnstr00036150 | |||||||||
| WBCnstr00041956 | |||||||||
| Construct_product | WBCnstr00011573 | ||||||||
| WBCnstr00014564 | |||||||||
| WBCnstr00016326 | |||||||||
| WBCnstr00022557 | |||||||||
| WBCnstr00036150 | |||||||||
| Antibody | WBAntibody00000863 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (146) | |||||||||
| Interaction (278) | |||||||||
| Map_info | Map | X | Position | -6.69708 | Error | 0.01114 | |||
| Positive | Positive_clone | C39E6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4493 | |||||||
| Pseudo_map_position | |||||||||
| Reference (32) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
