WormBase Tree Display for Gene: WBGene00003516

WBGene00003516 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C43E11
  Identity: Version: 1
    Name: CGC_name: nab-1 Person_evidence: WBPerson422
      Sequence_name: C43E11.6
      Molecular_name (20)
      Other_name: CELE_C43E11.6 Accession_evidence: NDB BX284601
      Public_name: nab-1
    DB_info: Database: AceView gene 1E803
        WormQTL gene WBGene00003516
        WormFlux gene WBGene00003516
        NDB locus_tag CELE_C43E11.6
        Panther gene CAEEL|WormBase=WBGene00003516|UniProtKB=H2KYW1
          family PTHR16154
        NCBI gene 172021
        RefSeq protein NM_001382891.1
            NM_001382888.1
            NM_001379754.3
            NM_001392124.1
            NM_001379751.3
        TREEFAM TREEFAM_ID TF105540
        TrEMBL UniProtAcc Q5R3Y6
            H2KYW3
            H2KYW1
            H2KYW2
            Q95Q64
        UniProt_GCRP UniProtAcc H2KYW1
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nab
    Allele (99)
    Strain: WBStrain00031725
      WBStrain00035645
    RNASeq_FPKM (74)
    GO_annotation (19)
    Contained_in_operon: CEOP1156
    Ortholog (42)
    Paralog: WBGene00015480 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle. Paper_evidence: WBPaper00004402
            WBPaper00015589
            WBPaper00016685
            WBPaper00018570
            WBPaper00019330
          Curator_confirmed: WBPerson1843
          Date_last_updated: 18 Jan 2005 00:00:00
      Automated_description: Predicted to enable actin filament binding activity. Involved in synapse assembly. Located in actin cytoskeleton and presynapse. Expressed in several structures, including egg-laying apparatus; excretory canal; hermaphrodite distal tip cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hepatocellular carcinoma; and schizophrenia. Is an ortholog of human PPP1R9A (protein phosphatase 1 regulatory subunit 9A) and PPP1R9B (protein phosphatase 1 regulatory subunit 9B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9298)
      DOID:12858 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14946)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9298)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9298)
  Molecular_info: Corresponding_CDS: C43E11.6a
      C43E11.6b
      C43E11.6c
      C43E11.6d
      C43E11.6e
    Corresponding_transcript: C43E11.6a.1
      C43E11.6a.2
      C43E11.6a.3
      C43E11.6b.1
      C43E11.6b.2
      C43E11.6c.1
      C43E11.6d.1
      C43E11.6e.1
      C43E11.6e.2
      C43E11.6e.3
    Other_sequence (68)
    Associated_feature (18)
  Experimental_info: RNAi_result: WBRNAi00060405 Inferred_automatically: RNAi_primary
      WBRNAi00042385 Inferred_automatically: RNAi_primary
      WBRNAi00116849 Inferred_automatically: RNAi_primary
      WBRNAi00060407 Inferred_automatically: RNAi_primary
      WBRNAi00060406 Inferred_automatically: RNAi_primary
      WBRNAi00003144 Inferred_automatically: RNAi_primary
      WBRNAi00029761 Inferred_automatically: RNAi_primary
      WBRNAi00077331 Inferred_automatically: RNAi_primary
      WBRNAi00117197 Inferred_automatically: RNAi_primary
      WBRNAi00060404 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3538
      Expr3563
      Expr4956
      Expr1028517
      Expr1031610
      Expr1146374
      Expr2013851
      Expr2032091
    Drives_construct: WBCnstr00000608
      WBCnstr00011462
      WBCnstr00036078
    Construct_product: WBCnstr00011487
      WBCnstr00036078
    Microarray_results (55)
    Expression_cluster (163)
    Interaction (27)
  Map_info: Map: I Position: -1.56416 Error: 0.004659
    Positive: Positive_clone: C43E11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4412
        4507
        5329
    Pseudo_map_position
  Reference (16)
  Remark: Sequence connection from [Gleason M, Miller DM]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene