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WormBase Tree Display for Gene: WBGene00003822

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WBGene00003822	SMap	S_parent	Sequence	CHROMOSOME_II
	Identity	Version	4
		Name	CGC_name	nsy-1	Person_evidence	WBPerson42
			Sequence_name	F59A6.1
			Molecular_name	F59A6.1a
				F59A6.1a.1
				CE44901
				F59A6.1b
				CE50862
				F59A6.1b.1
			Other_name	esp-8
				ask-1
				xts-1	Person_evidence	WBPerson9709
				srf-6
				CELE_F59A6.1	Accession_evidence	NDB	BX284602
			Public_name	nsy-1
		DB_info	Database (12)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:33	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	25 Oct 2016 10:44:04	WBPerson2970	Name_change	Other_name	xts-1
				3	02 Mar 2018 10:40:21	WBPerson4025	Event	Split_into	WBGene00303064
				4	02 Aug 2019 15:22:42	WBPerson1983	Name_change	Other_name	srf-6
			Split_into	WBGene00303064
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	nsy
		Allele (121)
		Legacy_information	ky400 homozygotes lose neuronal asymmetry, express str-2::GFPin both AWC neurons. ky542, ky397 similar.All 3 probable nulls: stop codons in F59A6.1, encoding homolog of Human MAPKKK ASK1.
		Strain (11)
		RNASeq_FPKM (74)
		GO_annotation (59)
		Ortholog	WBGene00057457	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00025376	Caenorhabditis briggsae	From_analysis	Hillier-set
						OrthoMCL
						OMA
						Inparanoid_8
						WormBase-Compara
			WBGene00160944	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00157898	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00133267	Caenorhabditis japonica	From_analysis	TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00102966	Pristionchus pacificus	From_analysis	OMA
						WormBase-Compara
			WBGene00232496	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g7682	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g9956	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g11856	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g20816	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g8754	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g17921	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g7391	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g8517	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g10311	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP39.g27501	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP39.g814	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g5142	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00386.g10113	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cang_2012_03_13_11953.g23492	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-nsy-1	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Cnig_chr_II.g6482	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold599.g5353	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp11.Scaffold599.g5354	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00737.g14973	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_05975	Caenorhabditis latens	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g03195	Oscheius tipulae	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g03197	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g12321	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_20089400	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrII_pilon.g4394	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00213208	Caenorhabditis japonica	From_analysis	WormBase-Compara
			WBGene00246967	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00266043	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00286013	Trichuris muris	From_analysis	WormBase-Compara
			WBGene00287250	Trichuris muris	From_analysis	WormBase-Compara
			SGD:S000004354	Saccharomyces cerevisiae	From_analysis	OrthoInspector
						Panther
			FB:FBgn0014006	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-030827-3	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-030131-8638	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			ZFIN:ZDB-GENE-091204-246	Danio rerio	From_analysis	Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:6857	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:6858	Homo sapiens	From_analysis	EnsEMBL-Compara
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:31689	Homo sapiens	From_analysis	Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:1346876	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			MGI:1855691	Mus musculus	From_analysis	EnsEMBL-Compara
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			MGI:2448588	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:1304625	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			RGD:1306565	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:1560603	Rattus norvegicus	From_analysis	OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
		Paralog	WBGene00004161	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.	Paper_evidence	WBPaper00003760
						WBPaper00004610
						WBPaper00004669
						WBPaper00005370
					Curator_confirmed	WBPerson48
						WBPerson1843
					Date_last_updated	11 Jan 2011 00:00:00
			Automated_description	Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Experimental_model	DOID:670	Homo sapiens	Paper_evidence	WBPaper00038418
					Curator_confirmed	WBPerson324
					Date_last_updated	31 May 2019 00:00:00
		Potential_model	DOID:12858	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:6857)
			DOID:8677	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:6857)
	Models_disease_asserted	WBDOannot00000693
	Molecular_info	Corresponding_CDS	F59A6.1a
			F59A6.1b
		Corresponding_CDS_history	F59A6.1c:wp264
		Corresponding_transcript	F59A6.1a.1
			F59A6.1b.1
		Other_sequence (29)
		Associated_feature	WBsf657564
			WBsf987777
			WBsf987778
			WBsf987779
			WBsf987780
			WBsf1012168
			WBsf1012169
			WBsf221219
	Experimental_info (11)
	Map_info	Map	II	Position	-2.59263	Error	0.001611
		Positive	Inside_rearr	ccDf2
				maDf4
			Positive_clone	F59A6	Author_evidence	Sagasti A
					Inferred_automatically	From sequence, transcript, pseudogene data
		Negative	Outside_rearr	ccDf11
		Mapping_data	Pos_neg_data	10652
				10653
				10654
				10655
	Reference (158)
	Picture	WBPicture0000013079
		WBPicture0000013081
		WBPicture0000013093
	Remark	Sequence connection (nsy-1 = F59A6.1) from Sagasti A and Bargmann C [030204 ck1]
	Method	Gene