WormBase Tree Display for Gene: WBGene00004345

WBGene00004345 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: rgs-2 Person_evidence: WBPerson330
      Sequence_name: F16H9.1
      Molecular_name (12)
      Other_name: CELE_F16H9.1 Accession_evidence: NDB BX284606
      Public_name: rgs-2
    DB_info: Database: AceView gene XN345
        WormQTL gene WBGene00004345
        WormFlux gene WBGene00004345
        NDB locus_tag CELE_F16H9.1
        Panther gene CAEEL|WormBase=WBGene00004345|UniProtKB=P49808
          family PTHR10845
        NCBI gene 181414
        RefSeq protein NM_001270270.5
            NM_001392863.1
            NM_077723.6
            NM_001129662.4
        SwissProt UniProtAcc P49808
        TrEMBL UniProtAcc G5EFV0
            G5ECA3
            G5EFC5
        UniProt_GCRP UniProtAcc P49808
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rgs
    Allele (258)
    Strain: WBStrain00026362
      WBStrain00026360
    RNASeq_FPKM (74)
    GO_annotation: 00011399
      00047258
    Ortholog (47)
    Paralog: WBGene00004344 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004346 Caenorhabditis elegans From_analysis: Panther
      WBGene00004347 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004354 Caenorhabditis elegans From_analysis: Panther
      WBGene00004353 Caenorhabditis elegans From_analysis: Panther
      WBGene00004350 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001145 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001179 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004349 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rgs-2 encodes a regulator of G protein signaling; by homology, RGS-2 is predicted to function as a GTPase-activating protein for heterotrimeric G-protein alpha-subunits, and in vitro RGS-2 can stimulate the GTPase activity of purified GOA-1; in vivo, rgs-2 appears to function redundantly with rgs-1 to regulate egg-laying behavior when animals are refed following starvation; rgs-2 is expressed in pharyngeal and uterine muscles and in a subset of neurons, including neurons in the ventral cord and head- and tail-ganglia. Paper_evidence: WBPaper00004281
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Expressed in head neurons; pharyngeal muscle cell; tail neurons; uterine muscle; and ventral cord neurons. Is an ortholog of human RGS19 (regulator of G protein signaling 19). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F16H9.1a
      F16H9.1b
      F16H9.1c
      F16H9.1d
    Corresponding_transcript: F16H9.1a.1
      F16H9.1b.1
      F16H9.1c.1
      F16H9.1d.1
    Other_sequence (40)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00112305 Inferred_automatically: RNAi_primary
      WBRNAi00044841 Inferred_automatically: RNAi_primary
      WBRNAi00013436 Inferred_automatically: RNAi_primary
      WBRNAi00031054 Inferred_automatically: RNAi_primary
      WBRNAi00112304 Inferred_automatically: RNAi_primary
      WBRNAi00112307 Inferred_automatically: RNAi_primary
      WBRNAi00112306 Inferred_automatically: RNAi_primary
      WBRNAi00112303 Inferred_automatically: RNAi_primary
      WBRNAi00112308 Inferred_automatically: RNAi_primary
      WBRNAi00112309 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1049
      Expr11589
      Expr1019382
      Expr1032163
      Expr1148805
      Expr2015325
      Expr2033559
    Drives_construct: WBCnstr00000298
      WBCnstr00004866
      WBCnstr00008978
      WBCnstr00010049
      WBCnstr00035551
    Construct_product: WBCnstr00004866
      WBCnstr00010049
      WBCnstr00035551
    Antibody: WBAntibody00001586
    Microarray_results (34)
    Expression_cluster: WBPaper00024970:GABAergic_neuron_specific
      WBPaper00032976:dosage_compensated_genes
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040420:FLP_enriched
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Spermatogenic
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00046161:Q40-aggregate-protein_Day7_Sarcosyl-insoluble
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050496:unc-39(hp701)_regulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053664:ins-11(tm1053)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061340:ADL
      WBPaper00061340:AIY
      WBPaper00061340:ASK
      WBPaper00061340:AWA
      WBPaper00061340:DD
      WBPaper00061340:I5
      WBPaper00061340:PVT
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:kin-29_2839-unc-9_3883
      WBPaper00061527:rgs-2_11061-pde-1
      WBPaper00061651:ADF_enriched
      WBPaper00061651:ADL_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:ASEL_enriched
      WBPaper00061651:ASH_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:AWA_enriched
      WBPaper00061651:AWB_enriched
      WBPaper00061651:AWC_OFF_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:I4_enriched
      WBPaper00061651:NSM_enriched
      WBPaper00061651:PHA_enriched
      WBPaper00061651:PHB_enriched
      WBPaper00061651:PLN_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:PVQ_enriched
      WBPaper00061651:PVT_enriched
      WBPaper00061651:RIA_enriched
      WBPaper00061651:RIP_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:VC_enriched
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065158:AFD_enriched
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:19_0
      WBPaper00065841:50_0
      WBPaper00065841:65_0
      WBPaper00065841:83_0
      WBPaper00065841:112_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025032:cluster_84
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp1
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037113:Diazinon_16C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (33)
  Map_info: Map: X Position: 8.11575 Error: 0.023369
    Positive: Positive_clone: F16H9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4581
        4634
        5420
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene