WormBase Tree Display for Gene: WBGene00004393
expand all nodes | collapse all nodes | view schema
| WBGene00004393 | SMap | S_parent | Sequence | B0414 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rnt-1 | Person_evidence | WBPerson83 | |||||
| Sequence_name | B0414.2 | ||||||||
| Molecular_name | B0414.2 | ||||||||
| B0414.2.1 | |||||||||
| CE24772 | |||||||||
| B0414.2.2 | |||||||||
| B0414.2.3 | |||||||||
| Other_name | run | Accession_evidence | AF153275 | ||||||
| mab-2 | Person_evidence | WBPerson759 | |||||||
| WBPerson699 | |||||||||
| WBPerson3750 | |||||||||
| run-1 | Paper_evidence | WBPaper00003892 | |||||||
| CELE_B0414.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | rnt-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rnt | ||||||||
| Reference_allele | WBVar00143855 | ||||||||
| Allele (143) | |||||||||
| Legacy_information | e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. | ||||||||
| See also e1241 | |||||||||
| [C.elegansII] e1241 : adult male has 6-18 missing copulatory rays as a result of variable failures of V and T lineages; bursa often grossly distorted. ME0/ME1. Hermaphrodite gross phenotype normal; late hypodermal V and T divisions variably defective. ES1 (hermaphrodite) ES3 (adult male). NA1. [Hodgkin 1983a; Link et al. 1988; CB] | |||||||||
| Strain | WBStrain00035360 | ||||||||
| WBStrain00035361 | |||||||||
| WBStrain00035362 | |||||||||
| WBStrain00040727 | |||||||||
| WBStrain00001748 | |||||||||
| WBStrain00035579 | |||||||||
| WBStrain00004456 | |||||||||
| WBStrain00008477 | |||||||||
| WBStrain00051045 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (46) | |||||||||
| Structured_description | Concise_description | rnt-1 encodes a transcription factor that is the sole C. elegans member of the Runx family of transcriptional regulators; rnt-1 activity is required for several developmental processes, including regulation of hypodermal seam cell proliferation and proper development of the male tail; rnt-1 mutant animals also exhibit a slight reduction in body size which is enhanced by starvation; RNT-1 can physically interact with SMA-4 and regulates, either directly or indirectly, expression of tlp-1 and cki-1, which encode a C2H2 zinc finger and CDK inhibitor, respectively; RNT-1::GFP reporter fusions are expressed in the nuclei of hypodermal seam cells and transiently in body wall muscles; in males, a RNT-1::GFP is expressed in cells derived from the V5, V6 and T lineages that give rise to the sensory rays. | Paper_evidence | WBPaper00005040 | |||||
| WBPaper00024401 | |||||||||
| WBPaper00026860 | |||||||||
| WBPaper00026868 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of locomotion involved in locomotory behavior; and regulation of gene expression. Acts upstream of or within dopamine metabolic process. Located in nucleus. Part of core-binding activity factor complex. Expressed in body wall musculature; intestine; neurons; ray precursor cell; and seam cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and osteochondrodysplasia (multiple). Is an ortholog of human RUNX2 (RUNX family transcription factor 2) and RUNX3 (RUNX family transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (23) | ||||||||
| Molecular_info | Corresponding_CDS | B0414.2 | |||||||
| Corresponding_transcript | B0414.2.1 | ||||||||
| B0414.2.2 | |||||||||
| B0414.2.3 | |||||||||
| Other_sequence | CBC12954_1 | ||||||||
| Associated_feature (23) | |||||||||
| Transcription_factor | WBTranscriptionFactor000199 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00065557 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00039038 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028240 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063834 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00064608 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063835 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002853 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001354 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (22) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product | WBCnstr00010470 | ||||||||
| WBCnstr00011148 | |||||||||
| WBCnstr00012390 | |||||||||
| WBCnstr00012969 | |||||||||
| WBCnstr00016840 | |||||||||
| WBCnstr00018817 | |||||||||
| WBCnstr00018818 | |||||||||
| WBCnstr00022571 | |||||||||
| WBCnstr00035514 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (127) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| WBbiopr:00000073 | |||||||||
| WBbiopr:00000112 | |||||||||
| Map_info | Map | I | Position | 0.447019 | Error | 0.000263 | |||
| Positive | Positive_clone | B0414 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 329 | |||||||
| Multi_point | 205 | ||||||||
| 4641 | |||||||||
| 5090 | |||||||||
| Reference (75) | |||||||||
| Remark | |||||||||
| Method | Gene |
