WormBase Tree Display for Gene: WBGene00004719
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| WBGene00004719 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F15A2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sad-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | F15A2.6 | ||||||||
| Molecular_name | F15A2.6a | ||||||||
| F15A2.6a.1 | |||||||||
| CE28218 | |||||||||
| F15A2.6b | |||||||||
| CE40646 | |||||||||
| F15A2.6b.1 | |||||||||
| Other_name | CELE_F15A2.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | sad-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sad | ||||||||
| Allele (288) | |||||||||
| Strain | WBStrain00002260 | ||||||||
| WBStrain00001646 | |||||||||
| WBStrain00005268 | |||||||||
| WBStrain00023494 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (44) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, SAD-1 functions in a complex with STRD-1, with which it physically interacts in vivo, to regulate axonal-dendritic polarity and synapse organization; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons; SAD-1 localization to synapses depends upon STRD-1; SAD-1 exhibits kinase activity in vitro, phosphorylating recombinant human Tau. | Paper_evidence | WBPaper00004523 | |||||
| WBPaper00035545 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Jun 2010 00:00:00 | ||||||||
| Automated_description | Enables protein kinase activity. Involved in cellular component organization; cellular localization; and establishment or maintenance of cell polarity. Located in axon and dendrite. Expressed in nervous system. Is an ortholog of human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F15A2.6a | |||||||
| F15A2.6b | |||||||||
| Corresponding_CDS_history | F15A2.6:wp53 | ||||||||
| Corresponding_transcript | F15A2.6a.1 | ||||||||
| F15A2.6b.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct | WBCnstr00000850 | ||||||||
| WBCnstr00002485 | |||||||||
| WBCnstr00004357 | |||||||||
| WBCnstr00005298 | |||||||||
| WBCnstr00013124 | |||||||||
| WBCnstr00013265 | |||||||||
| WBCnstr00041292 | |||||||||
| WBCnstr00041293 | |||||||||
| Construct_product (18) | |||||||||
| Antibody | WBAntibody00000343 | ||||||||
| WBAntibody00001193 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction | WBInteraction000009146 | ||||||||
| WBInteraction000037605 | |||||||||
| WBInteraction000037606 | |||||||||
| WBInteraction000041221 | |||||||||
| WBInteraction000042724 | |||||||||
| WBInteraction000044444 | |||||||||
| WBInteraction000046447 | |||||||||
| WBInteraction000047914 | |||||||||
| WBInteraction000049083 | |||||||||
| WBInteraction000049598 | |||||||||
| WBInteraction000050043 | |||||||||
| WBInteraction000050220 | |||||||||
| WBInteraction000169656 | |||||||||
| WBInteraction000169657 | |||||||||
| WBInteraction000182919 | |||||||||
| WBInteraction000415025 | |||||||||
| WBInteraction000502712 | |||||||||
| WBInteraction000502838 | |||||||||
| WBInteraction000504223 | |||||||||
| WBInteraction000540884 | |||||||||
| WBInteraction000541723 | |||||||||
| WBInteraction000556339 | |||||||||
| WBInteraction000556881 | |||||||||
| WBInteraction000556882 | |||||||||
| WBInteraction000556883 | |||||||||
| WBInteraction000556884 | |||||||||
| WBInteraction000560647 | |||||||||
| WBInteraction000560648 | |||||||||
| WBInteraction000560649 | |||||||||
| WBInteraction000578608 | |||||||||
| WBInteraction000583884 | |||||||||
| WBInteraction000584340 | |||||||||
| WBInteraction000586819 | |||||||||
| Map_info | Map | X | Position | 12.6561 | Error | 0.012226 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F15A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4019 | |||||||
| 4196 | |||||||||
| 4276 | |||||||||
| Reference (54) | |||||||||
| Remark | [email 93 from R. Lee and cgc4523] | ||||||||
| Method | Gene |
