WormBase Tree Display for Gene: WBGene00004719
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WBGene00004719 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F15A2 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sad | ||||||
Allele (288) | |||||||
Strain | WBStrain00002260 | ||||||
WBStrain00001646 | |||||||
WBStrain00005268 | |||||||
WBStrain00023494 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Ortholog (44) | |||||||
Paralog (19) | |||||||
Structured_description | Concise_description | sad-1 encodes a novel serine/threonine protein kinase; SAD-1 activity is required for several aspects of presynaptic development, including termination of axon outgrowth and presynaptic vesicle clustering, in GABAergic motor neurons and the ASI amphid chemosensory neuron; in addition, SAD-1 functions in a complex with STRD-1, with which it physically interacts in vivo, to regulate axonal-dendritic polarity and synapse organization; SAD-1 is expressed in the nervous system, where it localizes asymmetrically to the synapse-rich regions of axons; SAD-1 localization to synapses depends upon STRD-1; SAD-1 exhibits kinase activity in vitro, phosphorylating recombinant human Tau. | Paper_evidence | WBPaper00004523 | |||
WBPaper00035545 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 28 Jun 2010 00:00:00 | ||||||
Automated_description | Enables protein kinase activity. Involved in cellular component organization; cellular localization; and establishment or maintenance of cell polarity. Located in axon and dendrite. Expressed in nervous system. Is an ortholog of human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | F15A2.6a | |||||
F15A2.6b | |||||||
Corresponding_CDS_history | F15A2.6:wp53 | ||||||
Corresponding_transcript | F15A2.6a.1 | ||||||
F15A2.6b.1 | |||||||
Other_sequence (26) | |||||||
Associated_feature (13) | |||||||
Experimental_info | RNAi_result (18) | ||||||
Expr_pattern (18) | |||||||
Drives_construct | WBCnstr00000850 | ||||||
WBCnstr00002485 | |||||||
WBCnstr00004357 | |||||||
WBCnstr00005298 | |||||||
WBCnstr00013124 | |||||||
WBCnstr00013265 | |||||||
WBCnstr00041292 | |||||||
WBCnstr00041293 | |||||||
Construct_product (18) | |||||||
Antibody | WBAntibody00000343 | ||||||
WBAntibody00001193 | |||||||
Microarray_results (30) | |||||||
Expression_cluster (173) | |||||||
Interaction (33) | |||||||
Map_info | Map | X | Position | 12.6561 | Error | 0.012226 | |
Well_ordered | |||||||
Positive | Positive_clone | F15A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4019 | |||||
4196 | |||||||
4276 | |||||||
Reference (54) | |||||||
Remark | [email 93 from R. Lee and cgc4523] | ||||||
Method | Gene |