WormBase Tree Display for Gene: WBGene00004732
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| WBGene00004732 | SMap | S_parent | Sequence | C18F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sax-7 | Person_evidence | WBPerson42 | |||||
| Sequence_name | C18F3.2 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | lad-1 | CGC_data_submission | |||||||
| CELE_C18F3.2 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | sax-7 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004732 | |||||
| WormFlux | gene | WBGene00004732 | |||||||
| NDB | locus_tag | CELE_C18F3.2 | |||||||
| NCBI | gene | 177602 | |||||||
| RefSeq | protein | NM_001038308.4 | |||||||
| NM_001038306.6 | |||||||||
| NM_001307233.3 | |||||||||
| NM_001038307.5 | |||||||||
| NM_001038305.3 | |||||||||
| NM_001307232.3 | |||||||||
| TrEMBL | UniProtAcc | W6RRX6 | |||||||
| Q4PIU9 | |||||||||
| W6RTH3 | |||||||||
| Q53U86 | |||||||||
| Q53U87 | |||||||||
| Q18100 | |||||||||
| UniProt_GCRP | UniProtAcc | Q53U87 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sax | ||||||||
| Allele (270) | |||||||||
| Strain (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | sax-7 encodes an ortholog of human L1CAM, and a paralog of lad-2; L1CAM is a member of the group of highly conserved transmembrane cell adhesion receptor molecules which belong to the immunuglobulin superfamily; SAX-7 is required for axon guidance, neurite outgrowth and maintenance of neuronal positioning through homophilic and heterophilic interactions; sax-7 also affects germline development, embryonic morphogenesis, gonadal morphogenesis and tissue attachment; SAX-7 function is regulated by its physical interaction with the ankyrin UNC-44, and the gamma-syntrophin STN-2; nonphosphorylated SAX-7 is ubiquitously expressed at sites of cell-cell contact and colocalizes with UNC-44. | Paper_evidence | WBPaper00004127 | |||||
| WBPaper00004840 | |||||||||
| WBPaper00026686 | |||||||||
| WBPaper00032183 | |||||||||
| WBPaper00025149 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 03 Jun 2007 00:00:00 | ||||||||
| Automated_description | Enables ankyrin binding activity. Involved in several processes, including cell development; establishment of mitotic spindle orientation; and regulation of cell morphogenesis. Located in several cellular components, including axolemma; lateral plasma membrane; and somatodendritic compartment. Expressed in several structures, including gonad; neurons; pharynx; somatic nervous system; and vulval cell. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060246 | |||||||
| Potential_model | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1939) | |||||
| Models_disease_asserted | WBDOannot00000053 | ||||||||
| Molecular_info | Corresponding_CDS | C18F3.2a | |||||||
| C18F3.2b | |||||||||
| C18F3.2c | |||||||||
| C18F3.2d | |||||||||
| C18F3.2e | |||||||||
| C18F3.2f | |||||||||
| Corresponding_CDS_history | C18F3.2:wp129 | ||||||||
| C18F3.2:wp145 | |||||||||
| Corresponding_transcript | C18F3.2a.1 | ||||||||
| C18F3.2b.1 | |||||||||
| C18F3.2c.1 | |||||||||
| C18F3.2d.1 | |||||||||
| C18F3.2e.1 | |||||||||
| C18F3.2f.1 | |||||||||
| Other_sequence (58) | |||||||||
| Associated_feature (50) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00101409 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00040967 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110314 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011018 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001509 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (20) | |||||||||
| Drives_construct | WBCnstr00001457 | ||||||||
| WBCnstr00001458 | |||||||||
| WBCnstr00001459 | |||||||||
| WBCnstr00001460 | |||||||||
| WBCnstr00017300 | |||||||||
| WBCnstr00018436 | |||||||||
| WBCnstr00040218 | |||||||||
| WBCnstr00041183 | |||||||||
| WBCnstr00042159 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000401 | ||||||||
| WBAntibody00000402 | |||||||||
| WBAntibody00000403 | |||||||||
| WBAntibody00002176 | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (184) | |||||||||
| Interaction (99) | |||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| Map_info | Map | IV | Position | 3.5916 | Error | 0.001877 | |||
| Positive | Positive_clone | C18F3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4049 | |||||||
| 4986 | |||||||||
| 4999 | |||||||||
| 5613 | |||||||||
| Reference (102) | |||||||||
| Remark | Description and Allele (ky146) data extracted from Zallen JA, Kirch SA, Bargmann CI [ck1 020828] | ||||||||
| Sequence connection from [Chen L, Bennett V] | |||||||||
| lad-1 was merged into this gene following advice from the CGC [030902 krb] | |||||||||
| Method | Gene |
