WormBase Tree Display for Gene: WBGene00004746

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WBGene00004746	SMap	S_parent	Sequence	CHROMOSOME_X
	Identity	Version	1
		Name	CGC_name	sdc-2	Person_evidence	WBPerson421
			Sequence_name	C35C5.1
			Molecular_name	C35C5.1
				C35C5.1.1
				CE18542
			Other_name	CELE_C35C5.1	Accession_evidence	NDB	BX284606
			Public_name	sdc-2
		DB_info	Database	AceView	gene	XM151
				WormQTL	gene	WBGene00004746
				WormFlux	gene	WBGene00004746
				NDB	locus_tag	CELE_C35C5.1
				Panther	gene	CAEEL\|WormBase=WBGene00004746\|UniProtKB=G5EBL3
					family	PTHR13270
				NCBI	gene	181341
				RefSeq	protein	NM_077523.7
				SwissProt	UniProtAcc	G5EBL3
				TREEFAM	TREEFAM_ID	TF350609
				UniProt_GCRP	UniProtAcc	G5EBL3
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:36	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	sdc
		Allele (134)
		Legacy_information	See also y15
			[C.elegansII] y15 : XX animals inviable and masculinized, XO animals WT. No maternal rescue. ES3 (XX); ME3.OA>20: y46, y74, y55 (weaker, Egl or Tra phenotypes). ???Cloned: 9.2 kb transcript, encodes predicted 2962 protein (344 kD), highly charged. [Nusbaum and Meyer 1989; TY]
		Strain	WBStrain00035098
			WBStrain00035100
			WBStrain00035166
			WBStrain00035105
		RNASeq_FPKM (74)
		GO_annotation	00009802
			00009803
			00009804
			00009805
			00009806
			00009807
			00009808
		Ortholog (33)
		Paralog	WBGene00018316	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation.	Paper_evidence	WBPaper00005215
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
			Automated_description	Involved in dosage compensation by hypoactivation of X chromosome and negative regulation of transcription by RNA polymerase II. Located in nuclear chromosome.	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	C35C5.1
		Corresponding_transcript	C35C5.1.1
		Other_sequence	AF111934
		Associated_feature	WBsf663360
			WBsf663361
			WBsf663362
			WBsf663363
			WBsf1007030
			WBsf1007031
			WBsf1023889
			WBsf236384
			WBsf236385
		Gene_product_binds	WBsf019092
			WBsf019093
		Transcription_factor	WBTranscriptionFactor000093
			WBTranscriptionFactor000689
	Experimental_info	RNAi_result (35)
		Expr_pattern	Expr10429
			Expr11875
			Expr1028636
			Expr1032344
			Expr1145975
			Expr2015659
			Expr2033892
		Drives_construct	WBCnstr00006791
			WBCnstr00015322
			WBCnstr00035415
		Construct_product	WBCnstr00005103
			WBCnstr00005104
			WBCnstr00006790
			WBCnstr00006791
			WBCnstr00035415
		Antibody	WBAntibody00000228
			WBAntibody00000496
			WBAntibody00000497
			WBAntibody00001184
			WBAntibody00002039
			WBAntibody00002042
			WBAntibody00002043
		Microarray_results (21)
		Expression_cluster	WBPaper00028867:PAL-1_induced_TF
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00037682:sma-2_sma-4_upregulated
			WBPaper00037950:all-neurons_embryo_enriched
			WBPaper00037950:AVA-neuron_embryo_enriched
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:BAG-neuron_embryo_enriched
			WBPaper00037950:coelomocytes_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_embryo_enriched
			WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
			WBPaper00040221:DAF-12_target_ALF4
			WBPaper00044736:flat_dev_expression
			WBPaper00045417:128Q-huntingtin_upreglated
			WBPaper00045521:Oogenic
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00046509:htz-1(ok3099)_downregulated
			WBPaper00046805:csr-1(RNAi)_downregulated_Set1
			WBPaper00046805:csr-1(RNAi)_downregulated_Set2
			WBPaper00048690:male-Z1-Z4_enriched
			WBPaper00048988:neuron_expressed
			WBPaper00049545:cco-1(RNAi)_downregulated
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:GABAergic-neuron_enriched
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00051265:F4_morc-1(tm6048)_upregulated
			WBPaper00051305:vit-2(ac3)_upregulated
			WBPaper00051404:alg-1(gk214)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(icb38)_upregulated
			WBPaper00053295:lin-22(ot269)_upregulated
			WBPaper00053302:stavudine_24h_regulated
			WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
			WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
			WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
			WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
			WBPaper00053321:PGCs_depleted_NuGen
			WBPaper00053388:dauer_regulated_Cluster1
			WBPaper00053814:15C_downregulated_OP50
			WBPaper00053814:15C_downregulated_PY79
			WBPaper00055334:DLC-1_interacting
			WBPaper00055354:eat-2(ad1116)_downregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055386:daf-2(e1370)_downregulated
			WBPaper00055386:eat-2(ad465)_downregulated
			WBPaper00055482:Tunicamycin_upregulated
			WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
			WBPaper00056139:gut-microbiota_downregulated
			WBPaper00056167:Cry5B_upregulated
			WBPaper00056443:sek-1(km4)_upregulated
			WBPaper00056809:smn-1(ok355)_upregulated
			WBPaper00056855:his-72(uge40)_downregulated
			WBPaper00057006:DietaryRestriction_downregulated
			WBPaper00058691:cfp-1(tm6369)_downregulated
			WBPaper00058691:set-2(bn129)_downregulated
			WBPaper00058691:sin-3(tm1276)_downregulated
			WBPaper00058711:paraquat_upregulated
			WBPaper00058725:sftb-1(cer39)_downregulated
			WBPaper00058948:PA14_downregulated
			WBPaper00059224:tph-1(mg280)_upregulated
			WBPaper00059356:BAZ-2_SET-6_interacting
			WBPaper00059471:EGL-43_interacting
			WBPaper00059664:srbc-48(ac23)_downregulated
			WBPaper00059987:Wounding_downregulated
			WBPaper00060661:sensory-neuron_enriched
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060909:atfs-1(cmh15)_downregulated
			WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061439:unc-30(ok613)_downregulated
			WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
			WBPaper00061527:pek-1_22220-pek-1_33
			WBPaper00061527:utx-1_2886-swan-1_2192
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00062193:skn-1(RNAi)_downregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062669:extracellular-vesicle_protein
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064107:lin-52(3A)_vs_lin-52(WT)_upregulated
			WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
			WBPaper00064315:mes-4(bn73)_upregulated_EGCs
			WBPaper00064716:paraquat_upregulated
			WBPaper00064871:hypoxia_downregulated_F1
			WBPaper00064939:vit-5(RNAi)_upregulated
			WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
			WBPaper00065158:AFD_enriched
			WBPaper00065975:P-body_vs_oocyte_enriched
			WBPaper00065975:P-body_vs_WholeAnimal_enriched
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066062:xrep-4(lax137)_upregulated
			WBPaper00066110:Cisplatin_downregulated_diploid
			WBPaper00066110:Doxorubicin_downregulated_diploid
			WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
			WBPaper00025032:cluster_9
			WBPaper00025032:cluster_17
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Enriched_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00030839:Embryo_A_Class
			WBPaper00030839:Embryo_Pan_Neuronal
			WBPaper00032062:age_regulated_genes
			WBPaper00032165:differentially_expressed_with_age_medoid_1
			WBPaper00036286:Pattern_D
			WBPaper00040823:alg-1(gk214)_downregulated
			WBPaper00040858:eQTL_regulated_developing
			WBPaper00040858:eQTL_regulated_juvenile
			WBPaper00040876:mir-35_upregulated
			WBPaper00041002:HQ_3d_2.0mM_Down
			WBPaper00041174:environmental
			WBPaper00041174:environmental_prime
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00041960:N2_fasting_upregulated_9hto12h
			WBPaper00041960:N2_fasting_upregulated_anytime
			WBPaper00046548:dafachronic-acid_downregulated
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5767]:cluster_4
			[cgc5767]:expression_class_E
			[cgc5767]:expression_class_ET
			[cgc5767]:expression_class_ET_max(122_min)
			[cgc5767]:expression_class_E_pi(53_min)
			[cgc5767]:expression_class_SE
			[cgc5767]:expression_class_SET
			[cgc5767]:expression_class_SE_pi(53_min)
			[cgc6390]:mixed_oogenesis-somatic
		Interaction (77)
		WBProcess	WBbiopr:00000056
	Map_info	Map	X	Position	4.34757	Error	0.06798
		Well_ordered
		Positive	Inside_rearr	yDp7
			Positive_clone	C03B2
				C35C5	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	1438
				1439
				1440
				1774
				2062
				2293
				3319
				3642
				3643
				3687
			Pos_neg_data (11)
		Landmark_gene
	Reference (135)
	Method	Gene