Inferred by orthology to human genes with DO annotation (HGNC:1742)
Disease_relevance
A disruption in the gene encoding Human Neurobeachin (LRBA), a protein involved in neuronal membrane protein traffic, is associated with Autism; studies of the elegans ortholog, sel-2, support Neurobeachin''s role in vesicle transport and show that sel-12/Neurobeachin is involved in cell surface protein delivery to the lysosome; sel-2 is also a negative regulator of Notch/lin-12 activity.