| WBGene00004776 | SMap | S_parent | Sequence | F59C12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | ser-1 | Person_evidence | WBPerson32 |
| | | Sequence_name | F59C12.2 |
| | | Molecular_name | F59C12.2a |
| | | | F59C12.2a.1 |
| | | | CE28481 |
| | | | F59C12.2b |
| | | | CE38526 |
| | | | F59C12.2b.1 |
| | | Other_name | 5-HT2CeL | Accession_evidence | EMBL | AF031414 |
| | | | | | | AF031415 |
| | | | 5-HT2CeS | Accession_evidence | EMBL | AF031414 |
| | | | | | | AF031415 |
| | | | CELE_F59C12.2 | Accession_evidence | NDB | BX284606 |
| | | Public_name | ser-1 |
| | DB_info | Database | WormQTL | gene | WBGene00004776 |
| | | | WormFlux | gene | WBGene00004776 |
| | | | NDB | locus_tag | CELE_F59C12.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004776|UniProtKB=O17470 |
| | | | | family | PTHR24247 |
| | | | NCBI | gene | 181716 |
| | | | RefSeq | protein | NM_001029557.5 |
| | | | | | NM_001029558.5 |
| | | | TREEFAM | TREEFAM_ID | TF351745 |
| | | | TrEMBL | UniProtAcc | O17470 |
| | | | | | G5ECV2 |
| | | | UniProt_GCRP | UniProtAcc | O17470 |
| | | | OMIM | gene | 182135 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ser |
| | Allele (103) |
| | Legacy_information | [Leon Avery] ad1675 deletes bp 3708-5921 of F59C12.2. This is predicted to remove the C terminal cytoplasmic tail, but could still leave the protein functional. ad1675 mutants have no obvious phenotype. |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation (29) |
| | Ortholog (20) |
| | Paralog (20) |
| | Structured_description | Concise_description | ser-1 encodes a putative ortholog of mammalian 5-HT2 metabotropicserotonin receptors; SER-1 is required in both vulval muscle and neuronsfor the stimulation of egg-laying by serotonin (5-HT), but is completelydispensable for stimulation by the uptake inhibitor fluoxetine, andmostly dispensable for stimulation by the tricyclic antidepressantimipramine; SER-1 and SER-7 are redundantly required for normalegg-laying; SER-1 is required for normal turning during male mating, andser-1 mutants show reduced male tail curling in exogenous 5-HT, butser-1 males retain mating ability in the laboratory; SER-1 is weaklyrequired for pharyngeal pumping; SER-1 is expressed in diverse neurons(head, nerve ring, vulval, ventral cord motoneurons, tail, and manyothers), in diverse muscles (pharyngeal, vulval, and male-specificdiagonal), and in uterine cells; stimulation of heterologously expressedSER-1 induces a rise in free intracellular calcium; SER-1 has lowaffinity for 5-HT, and a mixture of pharmacological similarities tomammalian 5-HT1 and 5-HT2 receptors; SER-1 is stimulated byalpha-methyl-5HT, and probably antagonized by methiotheptin; SER-1 iscoexpressed with MPZ-1, has a PDZ binding motif (ETFL) that aids itssignalling, and binds PDZ domain 10 of MPZ-1 in vitro; SER-1'sstimulation of egg-laying is impeded by mpz-1(RNAi), if and only ifSER-1's ETFL motif is intact; mod-1;ser-1 double mutants subtly overbendtheir bodies while moving backward. | Paper_evidence (11) |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 20 Dec 2006 00:00:00 |
| | | Automated_description | Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including reproductive behavior; response to heat; and signal transduction. Located in plasma membrane. Expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; and obsessive-compulsive disorder. Is an ortholog of human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (16) |
| Molecular_info | Corresponding_CDS | F59C12.2a |
| | | F59C12.2b |
| | Corresponding_CDS_history | F59C12.2:wp142 |
| | Corresponding_transcript | F59C12.2a.1 |
| | | F59C12.2b.1 |
| | Other_sequence (19) |
| | Associated_feature (19) |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern (16) |
| | Drives_construct (14) |
| | Construct_product | WBCnstr00007173 |
| | | WBCnstr00007174 |
| | | WBCnstr00007175 |
| | | WBCnstr00007176 |
| | | WBCnstr00012947 |
| | | WBCnstr00017194 |
| | | WBCnstr00022944 |
| | | WBCnstr00022950 |
| | | WBCnstr00023051 |
| | | WBCnstr00035395 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038168:lin-35_upregulated |
| | | WBPaper00040209:B.thuringiensis_downregulated_MY15 |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00047132:skn-1(RNAi)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_PA14 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:hypoxia_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061040:eat-2(ad1116)_upregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:44_1 |
| | | WBPaper00065841:55_0 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065841:87_0 |
| | | WBPaper00065841:94_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:119_0 |
| | | cgc4489_group_9 |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00045294:50uM_TBBP_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | Interaction (94) |
| | Anatomy_function | WBbtf0587 |
| | | WBbtf0588 |
| Map_info | Map | X | Position | 24.0554 | Error | 0.000961 |
| | Positive | Positive_clone | F59C12 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4654 |
| | | | 5309 |
| | Pseudo_map_position |
| Reference (84) |
| Remark | sca-1 has sometimes been used to refer to his gene, but this is not correct as sca-1 is a SERCA (Sarco-Endoplasmic Reticulum Calcium ATPase) | CGC_data_submission |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
