WormBase Tree Display for Gene: WBGene00004789
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| WBGene00004789 | SMap | S_parent | Sequence | W10G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | sgk-1 | Person_evidence | WBPerson50 | |||||
| Sequence_name | W10G6.2 | ||||||||
| Molecular_name | W10G6.2a | ||||||||
| W10G6.2a.1 | |||||||||
| CE39527 | |||||||||
| W10G6.2b | |||||||||
| CE39528 | |||||||||
| W10G6.2a.2 | |||||||||
| W10G6.2b.1 | |||||||||
| Other_name | tag-74 | CGC_data_submission | |||||||
| CELE_W10G6.2 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | sgk-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sgk | ||||||||
| Allele (164) | |||||||||
| Strain | WBStrain00003895 | ||||||||
| WBStrain00023654 | |||||||||
| WBStrain00023656 | |||||||||
| WBStrain00035695 | |||||||||
| WBStrain00048359 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (43) | |||||||||
| Paralog (15) | |||||||||
| Structured_description | Concise_description | sgk-1 encodes a serine/threonine protein kinase that is orthologous to the mammalian serum- and glucocorticoid-inducible kinases (SGKs); in C. elegans, sgk-1 activity is required for normal egg laying, generation time, stress response, and adult life span; SGK-1 forms a complex with the AKT kinases with which it functions in parallel to mediate certain aspects of DAF-2/insulin-signaling; SGK-1 phosphorylates DAF-16 in vitro in a manner strictly dependent upon pdk-1 which encodes a 3-phosphoinositide-dependent kinase; an SGK-1::GFP fusion protein is expressed beginning in late embryonic stages and in larvae is seen in sensory and motor neurons as well as in the intestine; in neurons SGK-1::GFP localizes to the cytoplasm and the nucleus, while in the intestine SGK-1::GFP is found exclusively in the cytoplasm. | Paper_evidence | WBPaper00013413 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Oct 2007 00:00:00 | ||||||||
| Automated_description | Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in several processes, including mesendoderm development; positive regulation of vitellogenesis; and regulation of protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Expressed in intestine; neurons; and tail neurons. Human ortholog(s) of this gene implicated in cystadenocarcinoma (multiple); granulosa cell tumor; and hypertension. Is an ortholog of human C8orf44-SGK3 (C8orf44-SGK3 readthrough); SGK2 (serum/glucocorticoid regulated kinase 2); and SGK3 (serum/glucocorticoid regulated kinase family member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3603 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) | ||||
| DOID:2999 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) | ||||||
| DOID:3114 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10810) | ||||||
| Molecular_info | Corresponding_CDS | W10G6.2a | |||||||
| W10G6.2b | |||||||||
| Corresponding_CDS_history | W10G6.2:wp152 | ||||||||
| Corresponding_transcript | W10G6.2a.1 | ||||||||
| W10G6.2a.2 | |||||||||
| W10G6.2b.1 | |||||||||
| Other_sequence (65) | |||||||||
| Associated_feature | WBsf654686 | ||||||||
| WBsf671425 | |||||||||
| WBsf671426 | |||||||||
| WBsf671427 | |||||||||
| WBsf238384 | |||||||||
| Experimental_info | RNAi_result (44) | ||||||||
| Expr_pattern | Expr2920 | ||||||||
| Expr12360 | |||||||||
| Expr13383 | |||||||||
| Expr13384 | |||||||||
| Expr1028504 | |||||||||
| Expr1032376 | |||||||||
| Expr1158648 | |||||||||
| Expr2015802 | |||||||||
| Expr2034035 | |||||||||
| Drives_construct | WBCnstr00000182 | ||||||||
| WBCnstr00020685 | |||||||||
| WBCnstr00022723 | |||||||||
| WBCnstr00035387 | |||||||||
| WBCnstr00039281 | |||||||||
| WBCnstr00039282 | |||||||||
| Construct_product | WBCnstr00000182 | ||||||||
| WBCnstr00017996 | |||||||||
| WBCnstr00020685 | |||||||||
| WBCnstr00035387 | |||||||||
| Antibody | WBAntibody00001662 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (140) | |||||||||
| Interaction (216) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000039 | |||||||||
| WBbiopr:00000074 | |||||||||
| Map_info | Map | X | Position | 23.6985 | Error | 0.006601 | |||
| Positive | Positive_clone | W10G6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4658 | |||||||
| Pseudo_map_position | |||||||||
| Reference (96) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
