WormBase Tree Display for Gene: WBGene00004921
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| WBGene00004921 | SMap | S_parent | Sequence | F31E8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | snt-1 | Person_evidence | WBPerson508 | |||||
| Sequence_name | F31E8.2 | ||||||||
| Molecular_name | F31E8.2a | ||||||||
| F31E8.2a.1 | |||||||||
| CE02711 | |||||||||
| F31E8.2b | |||||||||
| CE28229 | |||||||||
| F31E8.2b.1 | |||||||||
| Other_name | ric-2 | ||||||||
| unc-121 | |||||||||
| syt1 | Accession_evidence | EMBL | AJ303369 | ||||||
| syt-1 | |||||||||
| CELE_F31E8.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | snt-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | snt | ||||||||
| Allele (91) | |||||||||
| Legacy_information | [Rand JB] uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors. | ||||||||
| [C.elegansII] md125 : (pka ric-2) uncoordinated, slight shrinker, small, slow-growing, resistant to cholinesterase inhibitors; some pumping and defecation defects. OA2: ad596 (pka unc-121, Unc, worse when starved; ME2), n2665. Cloned: encodes synaptotagmin (54% identity to mammalian synaptotagmin) [Nonet et al. 1993; Nguyen et al. 1995; NM; RM] | |||||||||
| Complementation_data | [Rand JB] complements unc-104(e1265), egl-27(n170), let-263(mn240) | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (62) | |||||||||
| Paralog | WBGene00004922 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004923 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004924 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011682 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004926 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004925 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004316 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006306 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020861 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | snt-1 encodes two proteins, SNT-1A and SNT-1B, orthologous to synaptotagmin; SNT-1 is required for synaptic vesicle exocytosis and neurotransmitter release as well as for synaptic vesicle recycling via clathrin-mediated endocytosis; accordingly, snt-1 activity is required for a variety of behaviors including pharyngeal pumping, locomotion, and defecation; SNT-1A and SNT-1B isoforms are expressed in neurons, with SNT-1A typically expressed at higher levels, and in a greater number of neurons, than SNT-1B; in addition, SNT-1B is exclusively expressed in the excretory duct cell and a group of tail neurons including DVB, a GABAergic neuron required for defecation. | Paper_evidence | WBPaper00001709 | |||||
| WBPaper00001750 | |||||||||
| WBPaper00002316 | |||||||||
| WBPaper00029143 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Apr 2007 00:00:00 | ||||||||
| Automated_description | Enables calcium ion sensor activity and calcium-dependent phospholipid binding activity. Involved in several processes, including defecation; regulation of pharyngeal pumping; and synaptic vesicle endocytosis. Located in synaptic vesicle. Expressed in several structures, including excretory gland cell; gonad; nervous system; pharyngeal gland cell; and rectal gland cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 7. Is an ortholog of human SYT1 (synaptotagmin 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110659 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11510) | ||||
| DOID:3635 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11510) | ||||||
| Molecular_info | Corresponding_CDS | F31E8.2a | |||||||
| F31E8.2b | |||||||||
| Corresponding_transcript | F31E8.2a.1 | ||||||||
| F31E8.2b.1 | |||||||||
| Other_sequence | MI03396 | ||||||||
| AS10851 | |||||||||
| HS00323 | |||||||||
| AS10727 | |||||||||
| AS12687 | |||||||||
| AS10904 | |||||||||
| ACC09619_1 | |||||||||
| AS10812 | |||||||||
| HSC00659_1 | |||||||||
| Tcol_isotig13120 | |||||||||
| EY473726.1 | |||||||||
| HBC16849_1 | |||||||||
| HBC14703_1 | |||||||||
| Oden_isotig19453 | |||||||||
| FC549136.1 | |||||||||
| XIC01345_1 | |||||||||
| Dviv_isotig23046 | |||||||||
| NBC03575_1 | |||||||||
| OCC00009_1 | |||||||||
| Acan_isotig08667 | |||||||||
| EH005357.1 | |||||||||
| EY462925.1 | |||||||||
| HS01419 | |||||||||
| OOC03685_1 | |||||||||
| AS02845 | |||||||||
| TSC04915_1 | |||||||||
| EX015035.1 | |||||||||
| ASC11813_1 | |||||||||
| AI363551.1 | |||||||||
| Hbac_isotig06652 | |||||||||
| JI238718.1 | |||||||||
| TSC05527_1 | |||||||||
| SS02869 | |||||||||
| JI181478.1 | |||||||||
| Tcir_isotig30994 | |||||||||
| FC540460.1 | |||||||||
| EX913638.1 | |||||||||
| ACC15582_1 | |||||||||
| MIC02923_1 | |||||||||
| EY466243.1 | |||||||||
| EY461416.1 | |||||||||
| TS00057 | |||||||||
| NB08898 | |||||||||
| FC548347.1 | |||||||||
| EY466761.1 | |||||||||
| AIC00259_1 | |||||||||
| EY462698.1 | |||||||||
| FC543606.1 | |||||||||
| MJC03079_1 | |||||||||
| FE911314.1 | |||||||||
| MPC00168_1 | |||||||||
| FG351955.1 | |||||||||
| AI132733.1 | |||||||||
| MJ03960 | |||||||||
| EX010091.1 | |||||||||
| SSC02101_1 | |||||||||
| OVC00383_1 | |||||||||
| JI475285.1 | |||||||||
| XI03656 | |||||||||
| MP01029 | |||||||||
| TSC05629_1 | |||||||||
| BE239140.1 | |||||||||
| TS00285 | |||||||||
| HSC00336_1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00089992 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00046026 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090310 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092941 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00112395 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027612 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076365 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022346 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089812 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090151 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003269 | ||||||||
| WBCnstr00005350 | |||||||||
| WBCnstr00005351 | |||||||||
| WBCnstr00009600 | |||||||||
| WBCnstr00009601 | |||||||||
| WBCnstr00017690 | |||||||||
| WBCnstr00035321 | |||||||||
| WBCnstr00038765 | |||||||||
| WBCnstr00038766 | |||||||||
| Construct_product | WBCnstr00001653 | ||||||||
| WBCnstr00005350 | |||||||||
| WBCnstr00005351 | |||||||||
| WBCnstr00017690 | |||||||||
| WBCnstr00019062 | |||||||||
| WBCnstr00021442 | |||||||||
| WBCnstr00035321 | |||||||||
| WBCnstr00038765 | |||||||||
| WBCnstr00038766 | |||||||||
| Antibody | WBAntibody00000070 | ||||||||
| WBAntibody00000152 | |||||||||
| WBAntibody00000347 | |||||||||
| WBAntibody00000730 | |||||||||
| WBAntibody00000906 | |||||||||
| WBAntibody00001655 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (227) | |||||||||
| Interaction (77) | |||||||||
| Map_info | Map | II | Position | 0.115793 | Error | 0.000262 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F31E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| F58D4 | |||||||||
| K10B7 | |||||||||
| Mapping_data | 2_point | 6025 | |||||||
| 6167 | |||||||||
| Multi_point | 2072 | ||||||||
| 2073 | |||||||||
| 2422 | |||||||||
| 2423 | |||||||||
| 2424 | |||||||||
| Pos_neg_data (18) | |||||||||
| Reference (115) | |||||||||
| Remark | [Rand JB] structural gene for synaptotagmin (cosmid hybridization by Nonet M). Null alleles viable. 14 additional md alleles exist. | ||||||||
| Method | Gene |
