WormBase Tree Display for Gene: WBGene00005152
expand all nodes | collapse all nodes | view schema
| WBGene00005152 | Identity | Version | 1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | CGC_name | srf-2 | Person_evidence | WBPerson494 | |||||
| Public_name | srf-2 | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Gene_class | srf | |||||||
| Reference_allele | WBVar00275419 | ||||||||
| Allele (49) | |||||||||
| Legacy_information | [C.elegansII] yj262 : increased binding of anti-cuticle antiserum, ectopic lectin WGA binding, no labelling with L1-specific mAb M38. Gross morphology WT.OA>20: yj133, yj422, ct104, ct117, dv1, dv2, dv37etc. All alleles recessive. [Hemmer et al. 1991; Link et al. 1992; AT; CL] | ||||||||
| Strain | WBStrain00022558 | ||||||||
| WBStrain00000251 | |||||||||
| WBStrain00004666 | |||||||||
| WBStrain00004729 | |||||||||
| WBStrain00004768 | |||||||||
| Structured_description | Concise_description | srf-2 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-2 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-2 mutants are resistant to infection by the nematode-specific pathogen, Microbacterium nematophilum, and do not show the tail-swelling response to infection; srf-2 mutants also show an altered response to nematophagous fungi, in the form of increased susceptibility. | Paper_evidence | WBPaper00001576 | |||||
| WBPaper00001002 | |||||||||
| WBPaper00001706 | |||||||||
| WBPaper00001280 | |||||||||
| WBPaper00004539 | |||||||||
| WBPaper00003623 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 Oct 2011 00:00:00 | ||||||||
| Automated_description | Used to study bacterial infectious disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00029153 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 10 May 2023 00:00:00 | ||||||||
| Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | |||||
| WBPaper00029153 | |||||||||
| WBPaper00026735 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Mar 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000014 | ||||||||
| Experimental_info | Expr_pattern | Expr16440 | |||||||
| Drives_construct | WBCnstr00043021 | ||||||||
| WBProcess | WBbiopr:00000008 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | I | Position | 5.23624 | Error | 0.183128 | |||
| Mapping_data | 2_point | 4748 | |||||||
| 4749 | |||||||||
| Multi_point | 1691 | ||||||||
| 1692 | |||||||||
| 3010 | |||||||||
| 3011 | |||||||||
| 3197 | |||||||||
| 3198 | |||||||||
| Pos_neg_data | 8076 | ||||||||
| 8088 | |||||||||
| 8096 | |||||||||
| Reference (37) | |||||||||
| Method | Gene |
