WormBase Tree Display for Gene: WBGene00006352

WBGene00006352 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: sur-6 Person_evidence: WBPerson237
      Sequence_name: F26E4.1
      Molecular_name: F26E4.1
        F26E4.1.1
        CE09685
      Other_name: CELE_F26E4.1 Accession_evidence: NDB BX284601
      Public_name: sur-6
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sur
    Allele (58)
    Legacy_information: [Sieburth DS] sur for suppressor of ras. suppresses the multivulva phenotype caused by let-60(n1046gf). ku123 causes no phenotype. ku123 is dominant
    Strain: WBStrain00001777
      WBStrain00026511
      WBStrain00026525
      WBStrain00035415
      WBStrain00037362
      WBStrain00007339
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (52)
    Structured_description: Concise_description: sur-6 encodes a regulatory (B) subunit of serine/threonine protein phosphatase 2A (PP2A-B); sur-6 was initially identified in screens for mutations that suppress the Multivulva phenotype produced by an activated let-60/Ras mutation and enhance the vulvaless and larval lethality phenotype of a hypomorphic lin-45/Raf mutation; in addition, RNAi experiments demonstrate that sur-6 activity is also essential for embryonic development; genetic studies indicate that during vulval development SUR-6 likely acts with the KSR-1 kinase in a parallel pathway that positively regulates RTK-Ras-MAP kinase signaling. Paper_evidence: WBPaper00003726
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Apr 2008 00:00:00
      Automated_description: Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:0050962 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
  Molecular_info: Corresponding_CDS: F26E4.1
    Corresponding_transcript: F26E4.1.1
    Other_sequence (33)
    Associated_feature (14)
  Experimental_info: RNAi_result (42)
    Expr_pattern: Chronogram2080
      Expr5874
      Expr15731
      Expr1017534
      Expr1032559
      Expr1149549
      Expr2017137
      Expr2035273
    Drives_construct: WBCnstr00002590
      WBCnstr00034393
    Construct_product: WBCnstr00034393
    Antibody: WBAntibody00002241
    Microarray_results (22)
    Expression_cluster (119)
    Interaction: WBInteraction000000949
      WBInteraction000000950
      WBInteraction000000951
      WBInteraction000000952
      WBInteraction000001401
      WBInteraction000001402
      WBInteraction000002328
      WBInteraction000002329
      WBInteraction000002352
      WBInteraction000002353
      WBInteraction000002355
      WBInteraction000002356
      WBInteraction000002357
      WBInteraction000002708
      WBInteraction000002973
      WBInteraction000004555
      WBInteraction000006035
      WBInteraction000006260
      WBInteraction000006404
      WBInteraction000006482
      WBInteraction000006489
      WBInteraction000006510
      WBInteraction000006776
      WBInteraction000006904
      WBInteraction000006954
      WBInteraction000007001
      WBInteraction000007041
      WBInteraction000007170
      WBInteraction000007242
      WBInteraction000009336
      WBInteraction000009356
      WBInteraction000009571
      WBInteraction000028411
      WBInteraction000028491
      WBInteraction000028823
      WBInteraction000032695
      WBInteraction000033003
      WBInteraction000033205
      WBInteraction000033352
      WBInteraction000033743
      WBInteraction000033919
      WBInteraction000035294
      WBInteraction000037420
      WBInteraction000037984
      WBInteraction000039157
      WBInteraction000039742
      WBInteraction000039853
      WBInteraction000040100
      WBInteraction000040194
      WBInteraction000040196
      WBInteraction000040906
      WBInteraction000041303
      WBInteraction000041320
      WBInteraction000041408
      WBInteraction000041409
      WBInteraction000041460
      WBInteraction000041474
      WBInteraction000041475
      WBInteraction000041669
      WBInteraction000041715
      WBInteraction000042710
      WBInteraction000042711
      WBInteraction000043067
      WBInteraction000043255
      WBInteraction000043730
      WBInteraction000043734
      WBInteraction000044310
      WBInteraction000044311
      WBInteraction000044384
      WBInteraction000045202
      WBInteraction000045679
      WBInteraction000045845
      WBInteraction000046586
      WBInteraction000046718
      WBInteraction000047192
      WBInteraction000047491
      WBInteraction000047535
      WBInteraction000047878
      WBInteraction000048490
      WBInteraction000048511
      WBInteraction000048542
      WBInteraction000049046
      WBInteraction000049049
      WBInteraction000049050
      WBInteraction000049105
      WBInteraction000049415
      WBInteraction000049448
      WBInteraction000049449
      WBInteraction000049868
      WBInteraction000049947
      WBInteraction000049961
      WBInteraction000050048
      WBInteraction000050532
      WBInteraction000050540
      WBInteraction000050577
      WBInteraction000052121
      WBInteraction000102543
      WBInteraction000102732
      WBInteraction000107289
      WBInteraction000110703
      WBInteraction000114296
      WBInteraction000119144
      WBInteraction000126500
      WBInteraction000126608
      WBInteraction000135377
      WBInteraction000139111
      WBInteraction000141111
      WBInteraction000144459
      WBInteraction000150129
      WBInteraction000150145
      WBInteraction000150155
      WBInteraction000159114
      WBInteraction000163924
      WBInteraction000166327
      WBInteraction000166328
      WBInteraction000167594
      WBInteraction000168303
      WBInteraction000168315
      WBInteraction000169515
      WBInteraction000169726
      WBInteraction000169727
      WBInteraction000173866
      WBInteraction000173867
      WBInteraction000175486
      WBInteraction000181879
      WBInteraction000190837
      WBInteraction000193139
      WBInteraction000206662
      WBInteraction000208835
      WBInteraction000209581
      WBInteraction000215836
      WBInteraction000227413
      WBInteraction000236818
      WBInteraction000247147
      WBInteraction000274985
      WBInteraction000294542
      WBInteraction000294543
      WBInteraction000300616
      WBInteraction000300732
      WBInteraction000302779
      WBInteraction000312500
      WBInteraction000329236
      WBInteraction000329854
      WBInteraction000340270
      WBInteraction000340877
      WBInteraction000340878
      WBInteraction000340879
      WBInteraction000340880
      WBInteraction000340881
      WBInteraction000340882
      WBInteraction000340883
      WBInteraction000340884
      WBInteraction000340885
      WBInteraction000340886
      WBInteraction000340982
      WBInteraction000351310
      WBInteraction000358809
      WBInteraction000398516
      WBInteraction000402885
      WBInteraction000437818
      WBInteraction000456612
      WBInteraction000467338
      WBInteraction000474362
      WBInteraction000474994
      WBInteraction000518409
      WBInteraction000518410
      WBInteraction000518411
      WBInteraction000523326
      WBInteraction000523327
      WBInteraction000524419
      WBInteraction000536630
      WBInteraction000536705
      WBInteraction000540209
      WBInteraction000549399
      WBInteraction000551294
      WBInteraction000552087
      WBInteraction000556038
      WBInteraction000556039
      WBInteraction000556262
      WBInteraction000562940
      WBInteraction000568874
      WBInteraction000570916
      WBInteraction000571007
      WBInteraction000577787
      WBInteraction000580427
    WBProcess: WBbiopr:00000071
  Map_info: Map: I Position: 3.89256 Error: 0.002576
    Well_ordered
    Positive: Inside_rearr: qDf8
        qDf9
      Positive_clone: F26E4 Inferred_automatically: From sequence, transcript, pseudogene data
        K02A11
    Negative: Outside_rearr: qDf5
      Negative_clone: F26E4
    Mapping_data: Multi_point: 3575
        4838
        4866
        4802
        4836
      Pos_neg_data: 9160
        9161
        9162
  Reference (42)
  Method: Gene