WormBase Tree Display for Gene: WBGene00006352

WBGene00006352 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: sur-6 Person_evidence: WBPerson237
      Sequence_name: F26E4.1
      Molecular_name: F26E4.1
        F26E4.1.1
        CE09685
      Other_name: CELE_F26E4.1 Accession_evidence: NDB BX284601
      Public_name: sur-6
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sur
    Allele (58)
    Legacy_information: [Sieburth DS] sur for suppressor of ras. suppresses the multivulva phenotype caused by let-60(n1046gf). ku123 causes no phenotype. ku123 is dominant
    Strain: WBStrain00001777
      WBStrain00026511
      WBStrain00026525
      WBStrain00035415
      WBStrain00037362
      WBStrain00007339
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog: WBGene00026589 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00153918 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00154007 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00079858 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00130000 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00223877 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10003 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g724 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3680 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7789 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g13522 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g19274 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8006 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13378 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g19276 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g19277 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g585 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00066.g3218 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sur-6 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15319 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00607.g13480 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22055 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_000614 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g13432 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g23817 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10211400 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1900 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00248708 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00102375 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262628 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00266843 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286108 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000003158 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0004889 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-5474 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-2086 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-130530-565 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041010-39 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-130530-705 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-051120-168 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:9304 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:9305 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:9306 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:23732 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1289252 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1919228 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1920180 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2442660 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:631441 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620919 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620920 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:708356 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: sur-6 encodes a regulatory (B) subunit of serine/threonine protein phosphatase 2A (PP2A-B); sur-6 was initially identified in screens for mutations that suppress the Multivulva phenotype produced by an activated let-60/Ras mutation and enhance the vulvaless and larval lethality phenotype of a hypomorphic lin-45/Raf mutation; in addition, RNAi experiments demonstrate that sur-6 activity is also essential for embryonic development; genetic studies indicate that during vulval development SUR-6 likely acts with the KSR-1 kinase in a parallel pathway that positively regulates RTK-Ras-MAP kinase signaling. Paper_evidence: WBPaper00003726
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Apr 2008 00:00:00
      Automated_description: Predicted to enable protein phosphatase regulator activity. Involved in embryo development; nematode larval development; and positive regulation of vulval development. Predicted to be located in cytosol. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; spinocerebellar ataxia type 12; and systemic lupus erythematosus. Is an ortholog of human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) and PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:0050962 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9305)
  Molecular_info: Corresponding_CDS: F26E4.1
    Corresponding_transcript: F26E4.1.1
    Other_sequence (33)
    Associated_feature (14)
  Experimental_info: RNAi_result (42)
    Expr_pattern: Chronogram2080
      Expr5874
      Expr15731
      Expr1017534
      Expr1032559
      Expr1149549
      Expr2017137
      Expr2035273
    Drives_construct: WBCnstr00002590
      WBCnstr00034393
    Construct_product: WBCnstr00034393
    Antibody: WBAntibody00002241
    Microarray_results (22)
    Expression_cluster (119)
    Interaction (185)
    WBProcess: WBbiopr:00000071
  Map_info: Map: I Position: 3.89256 Error: 0.002576
    Well_ordered
    Positive: Inside_rearr: qDf8
        qDf9
      Positive_clone: F26E4 Inferred_automatically: From sequence, transcript, pseudogene data
        K02A11
    Negative: Outside_rearr: qDf5
      Negative_clone: F26E4
    Mapping_data: Multi_point: 3575
        4838
        4866
        4802
        4836
      Pos_neg_data: 9160
        9161
        9162
  Reference (42)
  Method: Gene