WormBase Tree Display for Gene: WBGene00006526
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| WBGene00006526 | SMap | S_parent | Sequence | ZC84 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tax-4 | Person_evidence | WBPerson148 | |||||
| Sequence_name | ZC84.2 | ||||||||
| Molecular_name | ZC84.2 | ||||||||
| ZC84.2.1 | |||||||||
| CE27352 | |||||||||
| Other_name | CELE_ZC84.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | tax-4 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tax | ||||||||
| Reference_allele | WBVar00095116 | ||||||||
| Allele (69) | |||||||||
| Legacy_information | See also | ||||||||
| [Komatsu H, Mori I] ks11 defective in chemotaxis, thermotaxis. | |||||||||
| [C.elegansII] p678 : defective chemotaxis to Na, cAMP; repelled by Cl; athermotactic; reduced brood size. OA3: p674, ks28, ks11 (athermotactic; defects in sensory axon outgrowth). Cloned: encodes predicted 772 aa protein with 36% identity to human cGMP-gated ion channel. [Dusenbery 1976; FK] | |||||||||
| Predicted polypeptide of 733aa, cyclic nucleotide gated channel family. p678 i Q82am, ks11 is P383L, ks28 is D218V. Predicted gene ZC84.2 | |||||||||
| Complementation_data | [Komatsu H, Mori I] presumably fails to complement tax-4(p678) tax-4(ks28). | ||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (68) | |||||||||
| Ortholog (53) | |||||||||
| Paralog | WBGene00000487 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000563 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006525 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022295 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00001171 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006830 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | tax-4 encodes a a cyclic nucleotide-gated channel subunit orthologous to the human gene ROD PHOTORECEPTOR CGMP-GATED CHANNEL (CNGA1; OMIM:123825); tax-4 is required for chemosensation and thermosensation; a TAX-4::GFP fusion protein is expressed in sensory neurons where it localizes to the cilia. | Paper_evidence | WBPaper00002585 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 01 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Involved in several processes, including detection of stimulus; positive regulation of macromolecule biosynthetic process; and response to temperature stimulus. Located in ciliary inversin compartment; dendrite; and non-motile cilium. Part of cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 2 and retinitis pigmentosa 49. Is an ortholog of human CNGA1 (cyclic nucleotide gated channel subunit alpha 1) and CNGA2 (cyclic nucleotide gated channel subunit alpha 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:13399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2150) | ||||
| DOID:0110377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2148) | ||||||
| DOID:0110007 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2150) | ||||||
| DOID:10584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2148) | ||||||
| Molecular_info | Corresponding_CDS | ZC84.2 | |||||||
| Corresponding_CDS_history | ZC84.2:wp47 | ||||||||
| Corresponding_transcript | ZC84.2.1 | ||||||||
| Other_sequence (20) | |||||||||
| Associated_feature | WBsf717958 | ||||||||
| WBsf993598 | |||||||||
| WBsf993599 | |||||||||
| WBsf993600 | |||||||||
| WBsf993601 | |||||||||
| WBsf1015558 | |||||||||
| WBsf1015559 | |||||||||
| WBsf225534 | |||||||||
| WBsf225535 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00059025 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00006988 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1595 | ||||||||
| Expr311 | |||||||||
| Expr7177 | |||||||||
| Expr11198 | |||||||||
| Expr1022497 | |||||||||
| Expr1162455 | |||||||||
| Expr2017307 | |||||||||
| Expr2035442 | |||||||||
| Drives_construct | WBCnstr00003292 | ||||||||
| WBCnstr00007997 | |||||||||
| WBCnstr00011144 | |||||||||
| WBCnstr00015859 | |||||||||
| WBCnstr00016057 | |||||||||
| WBCnstr00034324 | |||||||||
| WBCnstr00038440 | |||||||||
| Construct_product (12) | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (83) | |||||||||
| Interaction (106) | |||||||||
| Anatomy_function | WBbtf0125 | ||||||||
| WBbtf0165 | |||||||||
| WBbtf0256 | |||||||||
| WBbtf0258 | |||||||||
| WBbtf0560 | |||||||||
| WBbtf0561 | |||||||||
| WBbtf0887 | |||||||||
| WBbtf0974 | |||||||||
| WBbtf0975 | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | III | Position | 0.284326 | Error | 0.005718 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F54G8 | |||||||
| R07A8 | |||||||||
| ZC84 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3155 | |||||||
| 3156 | |||||||||
| Reference (292) | |||||||||
| Remark | see WBG 12-4:73(1993) Hidetoshi Komatsu is investigator in FK lab. | ||||||||
| see WBG 12-4 73(1993). Hidetoshi Komatsu is investigator in FK lab | |||||||||
| Extracted from Komatsu et al. (1996) | |||||||||
| Method | Gene |
