| WBGene00006742 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | T02C5.5 |
| | | Molecular_name (45) |
| | | Other_name | CELE_T02C5.5 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-2 |
| | DB_info | Database | AceView | gene | XD330 |
| | | | WormQTL | gene | WBGene00006742 |
| | | | WormFlux | gene | WBGene00006742 |
| | | | OMIM | disease | 141500 |
| | | | | gene | 601011 |
| | | | | | 601013 |
| | | | NDB | locus_tag | CELE_T02C5.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663 |
| | | | | family | PTHR45628 |
| | | | NCBI | gene | 180570 |
| | | | RefSeq | protein (15) |
| | | | TrEMBL | UniProtAcc | A0A1N7SYV7 |
| | | | | | A0A1N7SYU0 |
| | | | | | A0A1N7SYV5 |
| | | | | | A0A3B1E663 |
| | | | | | A0A1N7SYT1 |
| | | | | | G5EFB0 |
| | | | | | A0A3B1E695 |
| | | | | | A0A1N7SYT0 |
| | | | | | A0A1N7SYU6 |
| | | | | | A0A1N7SYU4 |
| | | | | | Q86G45 |
| | | | | | A0A1N7SYT8 |
| | | | | | A0A3B1DR32 |
| | | | | | A0A3B1E4Z9 |
| | | | | | Q8MPY5 |
| | | | UniProt_GCRP | UniProtAcc | A0A3B1E663 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (11) |
| Disease_info | Experimental_model | DOID:6364 | Homo sapiens | Paper_evidence | WBPaper00006272 |
| | | | | Accession_evidence | OMIM | 141500 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 14 Apr 2014 00:00:00 |
| | Potential_model | DOID:10024 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | | DOID:0080454 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | | DOID:0050956 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | | DOID:0112205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1392) |
| | | DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) |
| | | DOID:0111181 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | | DOID:0050214 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) |
| | | DOID:0050990 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) |
| | | DOID:6364 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) |
| | Disease_relevance | Mutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans. | Homo sapiens | Paper_evidence | WBPaper00006272 |
| | | | | Accession_evidence | OMIM | 601011 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 14 Apr 2014 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000025 |
| Molecular_info | Corresponding_CDS (15) |
| | Corresponding_CDS_history | T02C5.5b:wp102 |
| | | T02C5.5d:wp271 |
| | | T02C5.5e:wp272 |
| | Corresponding_transcript (15) |
| | Other_sequence (50) |
| | Associated_feature (42) |
| Experimental_info | RNAi_result (18) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00003100 |
| | | WBCnstr00003101 |
| | | WBCnstr00004845 |
| | | WBCnstr00004847 |
| | | WBCnstr00038221 |
| | Construct_product | WBCnstr00005852 |
| | | WBCnstr00005853 |
| | | WBCnstr00005854 |
| | | WBCnstr00020432 |
| | | WBCnstr00022471 |
| | | WBCnstr00023025 |
| | | WBCnstr00023027 |
| | Microarray_results (47) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040285:H2S_12hr_downregulated |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045316:prg-1_upregulated_L2 |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046161:Q40-aggregate-protein_Day7_Sarcosyl-insoluble |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00048423:LP133_LF21_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00057347:nhr-14(tm1473)_downreglated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_ASJ_AUA |
| | | WBPaper00061340:OLL |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:RIA |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:sre-33-ZK1025.1_8337 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_mRNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065841:39_1 |
| | | WBPaper00065841:66_0 |
| | | WBPaper00065841:70_1 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273) |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rde-3(ne298)_upregulated |
| | | WBPaper00027111:rde-3(r459)_upregulated |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041906:I-3690_vs_OP50_10d |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (139) |
| | Anatomy_function | WBbtf0544 |
| | | WBbtf0547 |
| | | WBbtf0550 |
| Map_info | Map | X | Position | -13.7946 | Error | 0.063386 |
| | Well_ordered |
| | Positive | Positive_clone | T02C5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 145 |
| | | | 153 |
| | | | 154 |
| | | | 155 |
| | | | 156 |
| | | | 157 |
| | | | 3151 |
| | | | 4456 |
| | | | 4457 |
| | | | 7099 |
| | | Multi_point (28) |
| | | Pos_neg_data (23) |
| | Landmark_gene |
| Reference (201) |
| Method | Gene |
