WormBase Tree Display for Gene: WBGene00006743

WBGene00006743 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-3 Person_evidence: WBPerson261
      Sequence_name: Y16B4A.1
      Molecular_name: Y16B4A.1
        Y16B4A.1.1
        CE29366
      Other_name: CELE_Y16B4A.1 Accession_evidence: NDB BX284606
      Public_name: unc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142996
    Allele: WBVar00142976
      WBVar00278502
      WBVar01474279
      WBVar00088887
      WBVar00087920
      WBVar00142957
      WBVar00089162
      WBVar02147544
      WBVar02148524
      WBVar00054267
      WBVar00142985
      WBVar00278501
      WBVar00087921
      WBVar01210552
      WBVar00525076
      WBVar01210553
      WBVar00525077
      WBVar01210554
      WBVar00525078
      WBVar01499887
      WBVar00525079
      WBVar01472672
      WBVar01499519
      WBVar01210555
      WBVar00525080
      WBVar01472673
      WBVar01210556
      WBVar01499888
      WBVar01472674
      WBVar01210557
      WBVar01622317
      WBVar00525081
      WBVar01210558
      WBVar00525082
      WBVar01622318
      WBVar01210559
      WBVar00525083
      WBVar01622319
      WBVar01760458
      WBVar01210560
      WBVar00525084
      WBVar01210561
      WBVar00525085
      WBVar02112879
      WBVar01499710
      WBVar00525086
      WBVar00525087
      WBVar00525088
      WBVar00525089
      WBVar00525090
      WBVar00095048
      WBVar01679721
      WBVar01788195
      WBVar01679722
      WBVar01679723
      WBVar01679724
      WBVar00068044
      WBVar00066499
      WBVar00296371
      WBVar01545027
      WBVar01545028
      WBVar01545029
      WBVar01489626
      WBVar02144119
      WBVar02144120
      WBVar02101700
      WBVar02013927
      WBVar02101701
      WBVar02013928
      WBVar02013929
      WBVar00142937
      WBVar02013930
      WBVar02013931
      WBVar02074954
      WBVar01704304
      WBVar01704305
      WBVar01704306
      WBVar01704307
      WBVar01704308
      WBVar01704309
      WBVar01573136
      WBVar01704310
      WBVar01704311
      WBVar00090691
      WBVar01704312
      WBVar01704313
      WBVar01704314
      WBVar01704315
      WBVar01704316
      WBVar01946464
      WBVar00090702
      WBVar01704317
      WBVar01946465
      WBVar00090703
      WBVar01704318
      WBVar00090709
      WBVar01704319
      WBVar00095134
      WBVar01704320
      WBVar01704321
      WBVar00313686
      WBVar01704322
      WBVar00142996
      WBVar00313687
      WBVar00085583
      WBVar01704323
      WBVar00313688
      WBVar01704324
      WBVar00085584
      WBVar01704325
      WBVar00085585
      WBVar01704326
      WBVar00085586
      WBVar00085587
      WBVar01704327
      WBVar01704328
      WBVar00085588
      WBVar00085589
      WBVar01704329
      WBVar01704330
      WBVar00085590
      WBVar00085591
      WBVar01704331
      WBVar00085592
      WBVar01704332
      WBVar01704333
      WBVar00085593
      WBVar00085594
      WBVar00234218
      WBVar00085595
      WBVar00085596
      WBVar00085597
      WBVar00085598
      WBVar00085599
      WBVar00218738
      WBVar00218740
      WBVar00218742
      WBVar00218743
      WBVar00218745
      WBVar02093481
      WBVar01820931
      WBVar01528092
      WBVar01528093
      WBVar01528094
      WBVar01528095
      WBVar01528096
      WBVar01528097
      WBVar02106007
      WBVar01528098
      WBVar01528099
      WBVar01528100
      WBVar02119816
      WBVar01210507
      WBVar01210508
      WBVar01981704
      WBVar01210509
      WBVar01981705
      WBVar01210510
      WBVar01981706
      WBVar02071483
      WBVar01210511
      WBVar01210512
      WBVar01210513
      WBVar02086884
      WBVar02005556
      WBVar01210514
      WBVar01210515
      WBVar02005557
      WBVar02005558
      WBVar01210516
      WBVar01210517
      WBVar01210518
      WBVar01210519
      WBVar01210520
      WBVar01210521
      WBVar01210522
      WBVar01210523
      WBVar01210524
      WBVar02009412
      WBVar01210525
      WBVar01210526
      WBVar01210527
      WBVar01210528
      WBVar01928598
      WBVar01210529
      WBVar01210530
      WBVar01928599
      WBVar01928600
      WBVar01210531
      WBVar01942216
      WBVar01210532
      WBVar01942217
      WBVar01210533
      WBVar01210534
      WBVar01210535
      WBVar01210536
      WBVar00525060
      WBVar00102055
      WBVar00525061
      WBVar01210537
      WBVar00525062
      WBVar01210538
      WBVar01210539
      WBVar00525063
      WBVar01210540
      WBVar00525064
      WBVar01210541
      WBVar00525065
      WBVar00525066
      WBVar01210542
      WBVar00525067
      WBVar01210543
      WBVar00525068
      WBVar01210544
      WBVar00237430
      WBVar01210545
      WBVar00525069
      WBVar00525070
      WBVar01210546
      WBVar00525071
      WBVar01210547
      WBVar00525072
      WBVar01210548
      WBVar01498960
      WBVar00525073
      WBVar01210549
      WBVar01210550
      WBVar00525074
      WBVar01500067
      WBVar01553130
      WBVar00525075
      WBVar01210551
    Legacy_information: e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.).
      [C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP]
    Strain (93)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (46)
    Structured_description: Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19087)
  Molecular_info: Corresponding_CDS: Y16B4A.1
    Corresponding_CDS_history: Y16B4A.1:wp62
    Corresponding_transcript: Y16B4A.1.1
    Other_sequence (23)
    Associated_feature: WBsf648757
      WBsf648758
      WBsf663592
      WBsf663593
      WBsf663594
      WBsf663595
      WBsf663596
      WBsf978939
      WBsf1008002
      WBsf1008003
      WBsf1008004
      WBsf1008005
      WBsf1008006
      WBsf1008007
      WBsf1024459
      WBsf1024460
      WBsf1024461
      WBsf1024462
      WBsf236718
    Transcription_factor: WBTranscriptionFactor000217
  Experimental_info: RNAi_result: WBRNAi00115872 Inferred_automatically: RNAi_primary
      WBRNAi00090173 Inferred_automatically: RNAi_primary
      WBRNAi00090014 Inferred_automatically: RNAi_primary
      WBRNAi00027739 Inferred_automatically: RNAi_primary
      WBRNAi00020068 Inferred_automatically: RNAi_primary
      WBRNAi00055554 Inferred_automatically: RNAi_primary
      WBRNAi00062789 Inferred_automatically: RNAi_primary
      WBRNAi00008787 Inferred_automatically: RNAi_primary
      WBRNAi00090332 Inferred_automatically: RNAi_primary
      WBRNAi00089778 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct (11)
    Construct_product (14)
    Antibody: WBAntibody00000177
    Microarray_results (21)
    Expression_cluster (188)
    Interaction (195)
  Map_info: Map: X Position: 21.3208 Error: 0.014822
    Well_ordered
    Positive: Positive_clone: F42D1
        Y16B4A Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: K01B4
    Mapping_data: 2_point (52)
      Multi_point (53)
      Pos_neg_data (39)
    Landmark_gene
  Reference (217)
  Remark: [Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431).
    Polymorphism detection method = Southern hybridisation krb 04/03/02
  Method: Gene