| WBGene00006743 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-3 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y16B4A.1 |
| | | Molecular_name | Y16B4A.1 |
| | | | Y16B4A.1.1 |
| | | | CE29366 |
| | | Other_name | CELE_Y16B4A.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-3 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142996 |
| | Allele (232) |
| | Legacy_information | e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.). |
| | | [C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP] |
| | Strain (93) |
| | RNASeq_FPKM (74) |
| | GO_annotation (27) |
| | Ortholog (46) |
| | Structured_description | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0081176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19087) |
| Molecular_info | Corresponding_CDS | Y16B4A.1 |
| | Corresponding_CDS_history | Y16B4A.1:wp62 |
| | Corresponding_transcript | Y16B4A.1.1 |
| | Other_sequence (23) |
| | Associated_feature (19) |
| | Transcription_factor | WBTranscriptionFactor000217 |
| Experimental_info | RNAi_result | WBRNAi00115872 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090173 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090014 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027739 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00020068 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055554 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062789 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00008787 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090332 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089778 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (13) |
| | Drives_construct (11) |
| | Construct_product (14) |
| | Antibody | WBAntibody00000177 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00032425:down_in_lin-35 |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:A-class-motor-neurons_CoreEnriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Allantoin_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056550:ceh-60(ok1485)_downregulated_AdultDay1 |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057254:MWCNT_downregulated_mRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC_parent |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVQ_parent |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:SMB |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061651:ASI_enriched |
| | | WBPaper00061651:AS_enriched |
| | | WBPaper00061651:AVA_enriched |
| | | WBPaper00061651:AVB_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PHC_enriched |
| | | WBPaper00061651:PVN_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:50_0 |
| | | WBPaper00065841:61_0 |
| | | WBPaper00065841:77_0 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:117_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065841:134_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2 |
| | | cgc4386_cluster_6_5 |
| | | cgc4489_group_13 |
| | | cgc4489_group_17 |
| | | WBPaper00025032:cluster_194 |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:eri-1(mg366)_upregulated |
| | | WBPaper00027111:rrf-1(pk1417)_upregulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (195) |
| Map_info | Map | X | Position | 21.3208 | Error | 0.014822 |
| | Well_ordered |
| | Positive | Positive_clone | F42D1 |
| | | | Y16B4A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | K01B4 |
| | Mapping_data | 2_point (52) |
| | | Multi_point (53) |
| | | Pos_neg_data (39) |
| | Landmark_gene |
| Reference | WBPaper00000031 |
| | WBPaper00000241 |
| | WBPaper00000486 |
| | WBPaper00000497 |
| | WBPaper00000513 |
| | WBPaper00000538 |
| | WBPaper00000608 |
| | WBPaper00000712 |
| | WBPaper00000761 |
| | WBPaper00000977 |
| | WBPaper00000978 |
| | WBPaper00001126 |
| | WBPaper00001218 |
| | WBPaper00001296 |
| | WBPaper00001443 |
| | WBPaper00001508 |
| | WBPaper00001686 |
| | WBPaper00001709 |
| | WBPaper00001736 |
| | WBPaper00001747 |
| | WBPaper00001852 |
| | WBPaper00001854 |
| | WBPaper00002004 |
| | WBPaper00002355 |
| | WBPaper00002485 |
| | WBPaper00002837 |
| | WBPaper00003083 |
| | WBPaper00003219 |
| | WBPaper00003394 |
| | WBPaper00003792 |
| | WBPaper00004310 |
| | WBPaper00004362 |
| | WBPaper00004405 |
| | WBPaper00004409 |
| | WBPaper00005148 |
| | WBPaper00005251 |
| | WBPaper00005423 |
| | WBPaper00005455 |
| | WBPaper00006103 |
| | WBPaper00006104 |
| | WBPaper00006397 |
| | WBPaper00010449 |
| | WBPaper00010673 |
| | WBPaper00010684 |
| | WBPaper00011061 |
| | WBPaper00011084 |
| | WBPaper00011116 |
| | WBPaper00011485 |
| | WBPaper00011986 |
| | WBPaper00012327 |
| | WBPaper00012659 |
| | WBPaper00012695 |
| | WBPaper00012705 |
| | WBPaper00012724 |
| | WBPaper00013454 |
| | WBPaper00013656 |
| | WBPaper00013747 |
| | WBPaper00013816 |
| | WBPaper00013820 |
| | WBPaper00013841 |
| | WBPaper00013953 |
| | WBPaper00013979 |
| | WBPaper00014051 |
| | WBPaper00014077 |
| | WBPaper00014086 |
| | WBPaper00014169 |
| | WBPaper00014206 |
| | WBPaper00014211 |
| | WBPaper00014378 |
| | WBPaper00014382 |
| | WBPaper00014736 |
| | WBPaper00014835 |
| | WBPaper00014955 |
| | WBPaper00014968 |
| | WBPaper00015083 |
| | WBPaper00015086 |
| | WBPaper00015329 |
| | WBPaper00015363 |
| | WBPaper00015364 |
| | WBPaper00015419 |
| | WBPaper00015423 |
| | WBPaper00015434 |
| | WBPaper00015435 |
| | WBPaper00015491 |
| | WBPaper00015656 |
| | WBPaper00015844 |
| | WBPaper00015878 |
| | WBPaper00015879 |
| | WBPaper00015897 |
| | WBPaper00015918 |
| | WBPaper00015981 |
| | WBPaper00015987 |
| | WBPaper00015988 |
| | WBPaper00015994 |
| | WBPaper00016000 |
| | WBPaper00016024 |
| | WBPaper00016027 |
| | WBPaper00016075 |
| | WBPaper00016131 |
| | WBPaper00016190 |
| | WBPaper00016200 |
| | WBPaper00016201 |
| | WBPaper00016243 |
| | WBPaper00016248 |
| | WBPaper00016289 |
| | WBPaper00016303 |
| | WBPaper00016365 |
| | WBPaper00016415 |
| | WBPaper00016499 |
| | WBPaper00016555 |
| | WBPaper00016750 |
| | WBPaper00017072 |
| | WBPaper00017088 |
| | WBPaper00017145 |
| | WBPaper00017232 |
| | WBPaper00017451 |
| | WBPaper00017932 |
| | WBPaper00018195 |
| | WBPaper00019357 |
| | WBPaper00019608 |
| | WBPaper00019775 |
| | WBPaper00020971 |
| | WBPaper00021851 |
| | WBPaper00021866 |
| | WBPaper00021867 |
| | WBPaper00021929 |
| | WBPaper00022080 |
| | WBPaper00022084 |
| | WBPaper00022132 |
| | WBPaper00022427 |
| | WBPaper00022637 |
| | WBPaper00022656 |
| | WBPaper00022711 |
| | WBPaper00022721 |
| | WBPaper00022726 |
| | WBPaper00022738 |
| | WBPaper00022874 |
| | WBPaper00022945 |
| | WBPaper00023008 |
| | WBPaper00023375 |
| | WBPaper00023546 |
| | WBPaper00024393 |
| | WBPaper00024812 |
| | WBPaper00025096 |
| | WBPaper00025117 |
| | WBPaper00025141 |
| | WBPaper00025755 |
| | WBPaper00026037 |
| | WBPaper00026083 |
| | WBPaper00026431 |
| | WBPaper00026788 |
| | WBPaper00027214 |
| | WBPaper00027299 |
| | WBPaper00027309 |
| | WBPaper00027751 |
| | WBPaper00029015 |
| | WBPaper00029020 |
| | WBPaper00029021 |
| | WBPaper00032049 |
| | WBPaper00032217 |
| | WBPaper00032446 |
| | WBPaper00034047 |
| | WBPaper00034710 |
| | WBPaper00036334 |
| | WBPaper00038186 |
| | WBPaper00038227 |
| | WBPaper00038491 |
| | WBPaper00038849 |
| | WBPaper00039185 |
| | WBPaper00040449 |
| | WBPaper00042548 |
| | WBPaper00042884 |
| | WBPaper00043328 |
| | WBPaper00043334 |
| | WBPaper00043383 |
| | WBPaper00043601 |
| | WBPaper00043622 |
| | WBPaper00043908 |
| | WBPaper00044285 |
| | WBPaper00044820 |
| | WBPaper00045660 |
| | WBPaper00046563 |
| | WBPaper00046717 |
| | WBPaper00047477 |
| | WBPaper00047931 |
| | WBPaper00048116 |
| | WBPaper00048262 |
| | WBPaper00049309 |
| | WBPaper00050590 |
| | WBPaper00051453 |
| | WBPaper00051709 |
| | WBPaper00052395 |
| | WBPaper00052647 |
| | WBPaper00052777 |
| | WBPaper00053154 |
| | WBPaper00053579 |
| | WBPaper00055090 |
| | WBPaper00056064 |
| | WBPaper00056130 |
| | WBPaper00057228 |
| | WBPaper00058002 |
| | WBPaper00058386 |
| | WBPaper00058390 |
| | WBPaper00059042 |
| | WBPaper00060444 |
| | WBPaper00061272 |
| | WBPaper00061738 |
| | WBPaper00061878 |
| | WBPaper00062568 |
| | WBPaper00063727 |
| | WBPaper00063734 |
| | WBPaper00063737 |
| | WBPaper00064591 |
| | WBPaper00064898 |
| | WBPaper00064917 |
| | WBPaper00065733 |
| | WBPaper00066042 |
| Remark | [Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431). |
| | Polymorphism detection method = Southern hybridisation krb 04/03/02 |
| Method | Gene |
