WormBase Tree Display for Gene: WBGene00006743

WBGene00006743 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-3 Person_evidence: WBPerson261
      Sequence_name: Y16B4A.1
      Molecular_name: Y16B4A.1
        Y16B4A.1.1
        CE29366
      Other_name: CELE_Y16B4A.1 Accession_evidence: NDB BX284606
      Public_name: unc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142996
    Allele (232)
    Legacy_information: e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.).
      [C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP]
    Strain (93)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (46)
    Structured_description: Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19087)
  Molecular_info: Corresponding_CDS: Y16B4A.1
    Corresponding_CDS_history: Y16B4A.1:wp62
    Corresponding_transcript: Y16B4A.1.1
    Other_sequence (23)
    Associated_feature (19)
    Transcription_factor: WBTranscriptionFactor000217
  Experimental_info: RNAi_result: WBRNAi00115872 Inferred_automatically: RNAi_primary
      WBRNAi00090173 Inferred_automatically: RNAi_primary
      WBRNAi00090014 Inferred_automatically: RNAi_primary
      WBRNAi00027739 Inferred_automatically: RNAi_primary
      WBRNAi00020068 Inferred_automatically: RNAi_primary
      WBRNAi00055554 Inferred_automatically: RNAi_primary
      WBRNAi00062789 Inferred_automatically: RNAi_primary
      WBRNAi00008787 Inferred_automatically: RNAi_primary
      WBRNAi00090332 Inferred_automatically: RNAi_primary
      WBRNAi00089778 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct (11)
    Construct_product (14)
    Antibody: WBAntibody00000177
    Microarray_results (21)
    Expression_cluster (188)
    Interaction (195)
  Map_info: Map: X Position: 21.3208 Error: 0.014822
    Well_ordered
    Positive: Positive_clone: F42D1
        Y16B4A Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: K01B4
    Mapping_data (3)
    Landmark_gene
  Reference: WBPaper00000031
    WBPaper00000241
    WBPaper00000486
    WBPaper00000497
    WBPaper00000513
    WBPaper00000538
    WBPaper00000608
    WBPaper00000712
    WBPaper00000761
    WBPaper00000977
    WBPaper00000978
    WBPaper00001126
    WBPaper00001218
    WBPaper00001296
    WBPaper00001443
    WBPaper00001508
    WBPaper00001686
    WBPaper00001709
    WBPaper00001736
    WBPaper00001747
    WBPaper00001852
    WBPaper00001854
    WBPaper00002004
    WBPaper00002355
    WBPaper00002485
    WBPaper00002837
    WBPaper00003083
    WBPaper00003219
    WBPaper00003394
    WBPaper00003792
    WBPaper00004310
    WBPaper00004362
    WBPaper00004405
    WBPaper00004409
    WBPaper00005148
    WBPaper00005251
    WBPaper00005423
    WBPaper00005455
    WBPaper00006103
    WBPaper00006104
    WBPaper00006397
    WBPaper00010449
    WBPaper00010673
    WBPaper00010684
    WBPaper00011061
    WBPaper00011084
    WBPaper00011116
    WBPaper00011485
    WBPaper00011986
    WBPaper00012327
    WBPaper00012659
    WBPaper00012695
    WBPaper00012705
    WBPaper00012724
    WBPaper00013454
    WBPaper00013656
    WBPaper00013747
    WBPaper00013816
    WBPaper00013820
    WBPaper00013841
    WBPaper00013953
    WBPaper00013979
    WBPaper00014051
    WBPaper00014077
    WBPaper00014086
    WBPaper00014169
    WBPaper00014206
    WBPaper00014211
    WBPaper00014378
    WBPaper00014382
    WBPaper00014736
    WBPaper00014835
    WBPaper00014955
    WBPaper00014968
    WBPaper00015083
    WBPaper00015086
    WBPaper00015329
    WBPaper00015363
    WBPaper00015364
    WBPaper00015419
    WBPaper00015423
    WBPaper00015434
    WBPaper00015435
    WBPaper00015491
    WBPaper00015656
    WBPaper00015844
    WBPaper00015878
    WBPaper00015879
    WBPaper00015897
    WBPaper00015918
    WBPaper00015981
    WBPaper00015987
    WBPaper00015988
    WBPaper00015994
    WBPaper00016000
    WBPaper00016024
    WBPaper00016027
    WBPaper00016075
    WBPaper00016131
    WBPaper00016190
    WBPaper00016200
    WBPaper00016201
    WBPaper00016243
    WBPaper00016248
    WBPaper00016289
    WBPaper00016303
    WBPaper00016365
    WBPaper00016415
    WBPaper00016499
    WBPaper00016555
    WBPaper00016750
    WBPaper00017072
    WBPaper00017088
    WBPaper00017145
    WBPaper00017232
    WBPaper00017451
    WBPaper00017932
    WBPaper00018195
    WBPaper00019357
    WBPaper00019608
    WBPaper00019775
    WBPaper00020971
    WBPaper00021851
    WBPaper00021866
    WBPaper00021867
    WBPaper00021929
    WBPaper00022080
    WBPaper00022084
    WBPaper00022132
    WBPaper00022427
    WBPaper00022637
    WBPaper00022656
    WBPaper00022711
    WBPaper00022721
    WBPaper00022726
    WBPaper00022738
    WBPaper00022874
    WBPaper00022945
    WBPaper00023008
    WBPaper00023375
    WBPaper00023546
    WBPaper00024393
    WBPaper00024812
    WBPaper00025096
    WBPaper00025117
    WBPaper00025141
    WBPaper00025755
    WBPaper00026037
    WBPaper00026083
    WBPaper00026431
    WBPaper00026788
    WBPaper00027214
    WBPaper00027299
    WBPaper00027309
    WBPaper00027751
    WBPaper00029015
    WBPaper00029020
    WBPaper00029021
    WBPaper00032049
    WBPaper00032217
    WBPaper00032446
    WBPaper00034047
    WBPaper00034710
    WBPaper00036334
    WBPaper00038186
    WBPaper00038227
    WBPaper00038491
    WBPaper00038849
    WBPaper00039185
    WBPaper00040449
    WBPaper00042548
    WBPaper00042884
    WBPaper00043328
    WBPaper00043334
    WBPaper00043383
    WBPaper00043601
    WBPaper00043622
    WBPaper00043908
    WBPaper00044285
    WBPaper00044820
    WBPaper00045660
    WBPaper00046563
    WBPaper00046717
    WBPaper00047477
    WBPaper00047931
    WBPaper00048116
    WBPaper00048262
    WBPaper00049309
    WBPaper00050590
    WBPaper00051453
    WBPaper00051709
    WBPaper00052395
    WBPaper00052647
    WBPaper00052777
    WBPaper00053154
    WBPaper00053579
    WBPaper00055090
    WBPaper00056064
    WBPaper00056130
    WBPaper00057228
    WBPaper00058002
    WBPaper00058386
    WBPaper00058390
    WBPaper00059042
    WBPaper00060444
    WBPaper00061272
    WBPaper00061738
    WBPaper00061878
    WBPaper00062568
    WBPaper00063727
    WBPaper00063734
    WBPaper00063737
    WBPaper00064591
    WBPaper00064898
    WBPaper00064917
    WBPaper00065733
    WBPaper00066042
  Remark: [Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431).
    Polymorphism detection method = Southern hybridisation krb 04/03/02
  Method: Gene