WBGene00006744 | SMap | S_parent | Sequence | F26C11 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-4 | Person_evidence | WBPerson261 |
| | | Sequence_name | F26C11.2 |
| | | Molecular_name | F26C11.2 |
| | | | F26C11.2.1 |
| | | | CE01560 |
| | | Other_name | ceh-4 |
| | | | CELE_F26C11.2 | Accession_evidence | NDB | BX284602 |
| | | Public_name | unc-4 |
| | DB_info | Database | AceView | gene | 2K188 |
| | | | WormQTL | gene | WBGene00006744 |
| | | | SignaLink | protein | WBGene00006744 |
| | | | WormFlux | gene | WBGene00006744 |
| | | | NDB | locus_tag | CELE_F26C11.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006744|UniProtKB=P29506 |
| | | | | family | PTHR24329 |
| | | | NCBI | gene | 174544 |
| | | | RefSeq | protein | NM_063737.2 |
| | | | SwissProt | UniProtAcc | P29506 |
| | | | UniProt_GCRP | UniProtAcc | P29506 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Allele (53) |
| | Possibly_affected_by | WBVar02152871 |
| | | WBVar02152872 |
| | | WBVar02153037 |
| | | WBVar02153038 |
| | Legacy_information | e120 : large healthy active moves forward well cannot back; ventral cord VA motoneurons have normal anatomy but synaptic inputs appropriate to VB motoneurons. ES3 ME0. NA5 (e26 etc.). |
| | | See also e2151, e2152, e2314, wd1 |
| | | [C.elegansII] e120 : large, healthy, active, moves forward well but cannot back; ventral cord VA motoneurons have normal anatomy but most have synaptic inputs appropriate to VB motoneurons. ES3 ME1. OA>15: e26, e2151, e2308, e2320 (deletion null,resembles e120), e2322ts (TSP L2-L3),wd1 etc. See also unc-37. Cloned: rare 1.2 kb transcript, encodes homeoprotein (pka ceh-4); unc-4:lacZ expressed in VA but not VB motor neurons. [White et al. 1992; Miller et al. 1992; NC] |
| | Strain (265) |
| | RNASeq_FPKM (74) |
| | GO_annotation (28) |
| | Ortholog (30) |
| | Paralog (20) |
| | Structured_description | Concise_description | The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. | Paper_evidence | WBPaper00001502 |
| | | | | | WBPaper00004594 |
| | | | | | WBPaper00005153 |
| | | | | | WBPaper00005237 |
| | | | | | WBPaper00005455 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Aug 2005 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and synaptic vesicle transport. Located in axon and nucleus. Expressed in I5 neuron; cholinergic neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F26C11.2 |
| | Corresponding_transcript | F26C11.2.1 |
| | Other_sequence | X64904 |
| | | JI482165.1 |
| | | Oden_isotig24826 |
| | | Acan_isotig12060 |
| | | Dviv_isotig25636 |
| | | JI228715.1 |
| | Associated_feature | WBsf650466 |
| | | WBsf978893 |
| | | WBsf223725 |
| | | WBsf223726 |
| | Transcription_factor | WBTranscriptionFactor000320 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern (12) |
| | Drives_construct (54) |
| | Construct_product | WBCnstr00006869 |
| | | WBCnstr00016592 |
| | | WBCnstr00016693 |
| | | WBCnstr00017159 |
| | | WBCnstr00022370 |
| | | WBCnstr00034179 |
| | Regulate_expr_cluster | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_CoreEnriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00046338:intestine_unique |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:PVT |
| | | WBPaper00061527:ckr-1-T09B9.3 |
| | | WBPaper00061651:AVF_enriched |
| | | WBPaper00061651:DA9_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:I5_enriched |
| | | WBPaper00061651:SAB_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VA_enriched |
| | | WBPaper00061651:VC_4_5_enriched |
| | | WBPaper00061651:VC_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065623:63 |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_2 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:14_2 |
| | | WBPaper00065841:19_0 |
| | | WBPaper00065841:105_0 |
| | | WBPaper00065841:123_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065841:145_0 |
| | | cgc4489_group_14 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Larval_A_Class |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00045673:colistin_upregulated |
| | Interaction (175) |
| | Anatomy_function | WBbtf0167 |
| | | WBbtf0168 |
| | | WBbtf0169 |
| | | WBbtf0231 |
| Map_info | Map | II | Position | 1.7701 | Error | 0.005634 |
| | Well_ordered |
| | Positive | Inside_rearr (17) |
| | | Positive_clone | C07E2 |
| | | | F26C11 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | mnDp34 |
| | | | mnDp35 |
| | | | mnDp36 |
| | Mapping_data | 2_point (56) |
| | | Multi_point (247) |
| | | Pos_neg_data (23) |
| | Landmark_gene |
| Reference (293) |
| Method | Gene |