WormBase Tree Display for Gene: WBGene00006744
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WBGene00006744 | SMap | S_parent | Sequence | F26C11 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-4 | Person_evidence | WBPerson261 | |||||
Sequence_name | F26C11.2 | ||||||||
Molecular_name | F26C11.2 | ||||||||
F26C11.2.1 | |||||||||
CE01560 | |||||||||
Other_name | ceh-4 | ||||||||
CELE_F26C11.2 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | unc-4 | ||||||||
DB_info | Database | AceView | gene | 2K188 | |||||
WormQTL | gene | WBGene00006744 | |||||||
SignaLink | protein | WBGene00006744 | |||||||
WormFlux | gene | WBGene00006744 | |||||||
NDB | locus_tag | CELE_F26C11.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006744|UniProtKB=P29506 | |||||||
family | PTHR24329 | ||||||||
NCBI | gene | 174544 | |||||||
RefSeq | protein | NM_063737.2 | |||||||
SwissProt | UniProtAcc | P29506 | |||||||
UniProt_GCRP | UniProtAcc | P29506 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Allele (53) | |||||||||
Possibly_affected_by | WBVar02152871 | ||||||||
WBVar02152872 | |||||||||
WBVar02153037 | |||||||||
WBVar02153038 | |||||||||
Legacy_information | e120 : large healthy active moves forward well cannot back; ventral cord VA motoneurons have normal anatomy but synaptic inputs appropriate to VB motoneurons. ES3 ME0. NA5 (e26 etc.). | ||||||||
See also e2151, e2152, e2314, wd1 | |||||||||
[C.elegansII] e120 : large, healthy, active, moves forward well but cannot back; ventral cord VA motoneurons have normal anatomy but most have synaptic inputs appropriate to VB motoneurons. ES3 ME1. OA>15: e26, e2151, e2308, e2320 (deletion null,resembles e120), e2322ts (TSP L2-L3),wd1 etc. See also unc-37. Cloned: rare 1.2 kb transcript, encodes homeoprotein (pka ceh-4); unc-4:lacZ expressed in VA but not VB motor neurons. [White et al. 1992; Miller et al. 1992; NC] | |||||||||
Strain (265) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Ortholog (30) | |||||||||
Paralog (20) | |||||||||
Structured_description | Concise_description | The unc-4 gene encodes a paired-class homeodomain protein with homologs in Drosophila and vertebrates; UNC-4 is required for establishing the identity of the A class motor neurons DA and VA, and is thus required for movement, axon guidance, and synapse formation; UNC-4 is negatively regulated by VAB-7, and UNC-4 activity requires UNC-37; unc-4 is expressed in the A-type motor neurons, DA and VA, the six VC motor neurons that innervate the vulval muscles, and the three SAB motor neurons; unc-4 is also expressed in the pharyngeal I5 motor neuron and the AVF neurons in the retrovesicular ganglion. | Paper_evidence | WBPaper00001502 | |||||
WBPaper00004594 | |||||||||
WBPaper00005153 | |||||||||
WBPaper00005237 | |||||||||
WBPaper00005455 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Aug 2005 00:00:00 | ||||||||
Automated_description | Enables DNA-binding transcription factor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and synaptic vesicle transport. Located in axon and nucleus. Expressed in I5 neuron; cholinergic neurons; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | F26C11.2 | |||||||
Corresponding_transcript | F26C11.2.1 | ||||||||
Other_sequence | X64904 | ||||||||
JI482165.1 | |||||||||
Oden_isotig24826 | |||||||||
Acan_isotig12060 | |||||||||
Dviv_isotig25636 | |||||||||
JI228715.1 | |||||||||
Associated_feature (4) | |||||||||
Transcription_factor | WBTranscriptionFactor000320 | ||||||||
Experimental_info | RNAi_result (15) | ||||||||
Expr_pattern (12) | |||||||||
Drives_construct (54) | |||||||||
Construct_product | WBCnstr00006869 | ||||||||
WBCnstr00016592 | |||||||||
WBCnstr00016693 | |||||||||
WBCnstr00017159 | |||||||||
WBCnstr00022370 | |||||||||
WBCnstr00034179 | |||||||||
Regulate_expr_cluster | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (98) | |||||||||
Interaction (175) | |||||||||
Anatomy_function | WBbtf0167 | ||||||||
WBbtf0168 | |||||||||
WBbtf0169 | |||||||||
WBbtf0231 | |||||||||
Map_info | Map | II | Position | 1.7701 | Error | 0.005634 | |||
Well_ordered | |||||||||
Positive | Inside_rearr (17) | ||||||||
Positive_clone | C07E2 | ||||||||
F26C11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Negative | Outside_rearr | mnDp34 | |||||||
mnDp35 | |||||||||
mnDp36 | |||||||||
Mapping_data | 2_point (56) | ||||||||
Multi_point (247) | |||||||||
Pos_neg_data (23) | |||||||||
Landmark_gene | |||||||||
Reference (293) | |||||||||
Method | Gene |