WormBase Tree Display for Gene: WBGene00006745

WBGene00006745 SMap: S_parent: Sequence: B0273
  Identity: Version: 1
    Name: CGC_name: unc-5 Person_evidence: WBPerson261
      Sequence_name: B0273.4
      Molecular_name (19)
      Other_name: CELE_B0273.4 Accession_evidence: NDB BX284604
      Public_name: unc-5
    DB_info: Database: AceView gene 4G260
        WormQTL gene WBGene00006745
        WormFlux gene WBGene00006745
        NDB locus_tag CELE_B0273.4
        Panther gene CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261
          family PTHR12582
        NCBI gene 177334
        RefSeq protein NM_001392311.1
            NM_068422.6
            NM_001306822.3
            NM_068421.6
            NM_001306820.3
            NM_001380233.1
        SwissProt UniProtAcc Q26261
        TREEFAM TREEFAM_ID TF316767
        UniProt_GCRP UniProtAcc Q26261
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142936
    Allele (350)
    Legacy_information: e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.).
      See also e2349, e2355, e2387
      [C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW]
    Strain (67)
    RNASeq_FPKM (74)
    GO_annotation (53)
    Ortholog: WBGene00063989 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00039055 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00139038 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00159503 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00074874 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00221992 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10748 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g4903 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g14877 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g6416 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g6417 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g6503 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g21532 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g3880 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3693 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g11764 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g28928 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g29434 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24123 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00068.g3279 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-5 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold470.g1638 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01223.g19372 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_19739 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013564 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10441 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g1389 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40329700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10464 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00211593 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00241016 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00277056 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00266557 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00293765 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0034013 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041213-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-9196 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-080908-2 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-080219-19 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060531-162 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-100921-23 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:12569 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:12567 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:18634 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:12568 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1095412 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:894682 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:894703 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:2389364 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621755 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621756 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1309245 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:735109 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Structured_description: Concise_description: unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. Paper_evidence: WBPaper00001619
            WBPaper00005582
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Jan 2006 00:00:00
      Automated_description: Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0273.4a
      B0273.4b
      B0273.4c
      B0273.4d
      B0273.4e
      B0273.4f
    Corresponding_CDS_history: B0273.4b:wp134
    Corresponding_transcript: B0273.4a.1
      B0273.4b.1
      B0273.4c.1
      B0273.4d.1
      B0273.4d.2
      B0273.4e.1
      B0273.4f.1
    Other_sequence: JI475712.1
      JI459463.1
      CR01727
      CRC00510_2
      CRC06468_1
      CR03346
      CJC11776_1
      JI165198.1
      Dviv_isotig23366
    Associated_feature (24)
  Experimental_info: RNAi_result (14)
    Expr_pattern (11)
    Drives_construct (17)
    Construct_product (13)
    Microarray_results (30)
    Expression_cluster (154)
    Interaction (206)
    WBProcess: WBbiopr:00000025
  Map_info (6)
  Reference (341)
  Remark: [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000)
  Method: Gene