e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.).
See also e2349, e2355, e2387
[C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW]
unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood.
Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C).