WormBase Tree Display for Gene: WBGene00006762
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| WBGene00006762 | SMap | S_parent | Sequence | Y37D8A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-25 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y37D8A.23 | ||||||||
| Molecular_name | Y37D8A.23a | ||||||||
| Y37D8A.23a.1 | |||||||||
| CE20226 | |||||||||
| Y37D8A.23b | |||||||||
| CE31832 | |||||||||
| Y37D8A.23c | |||||||||
| CE32012 | |||||||||
| Y37D8A.23b.1 | |||||||||
| Y37D8A.23c.1 | |||||||||
| Other_name | CELE_Y37D8A.23 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-25 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143000 | ||||||||
| Allele (165) | |||||||||
| Legacy_information | e156 : shrinker contracts both dorsally and ventrally when prodded; slow; poor backing; slightly small; deficient in GABA. ES3 ME2. NA4 (e265 e591). | ||||||||
| [C.elegansII] e156 : shrinker, contracts both dorsally and ventrally when prodded; slow; loopy Fab; poor backing; slightly small; Exp defect in defecation; deficient in GABA; some neuroanatomical defects (D motorneurons). ES3 ME2. OA>5: e265, e591, sa4, sa25 (similar). Cloned: encodes 416 aa GAD (glutamic aciddecarboxylase), 45% identity to human GAD65,67. unc-25:lacZ expressed in all GABAergic neurons. [Thomas 1990; McIntire et al. 1993; CZ; JT; MT] | |||||||||
| Strain (51) | |||||||||
| Component_of_genotype | WBGenotype00000128 | ||||||||
| WBGenotype00000129 | |||||||||
| WBGenotype00000130 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00000239 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00001839 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006409 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006562 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015467 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-25 encodes the C. elegans ortholog of the GABA neurotransmitter biosynthetic enzyme, glutamic acid decarboxylase (GAD); unc-25 activity is required for GABA synthesis and thus for normal synaptic transmission and GABA-mediated behaviors; UNC-25 is expressed specifically in the 26 GABAergic neurons as soon as they are generated and localizes to cell bodies, axonal branches, and synaptic regions, including some localization to synaptic vesicles; in the 19 type D GABAergic neurons, unc-25 expression is positively regulated by the UNC-30 homeodomain transcription factor, which binds to the unc-25 promoter in a sequence-specific manner. | Paper_evidence | WBPaper00001759 | |||||
| WBPaper00003350 | |||||||||
| WBPaper00003619 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 03 Jul 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in axon; perikaryon; and synapse. Expressed in EF neuron and neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; developmental and epileptic encephalopathy 89; and diabetes mellitus (multiple). Is an ortholog of human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
| DOID:0050669 | Homo sapiens | Paper_evidence | WBPaper00024523 | ||||||
| Accession_evidence | OMIM | 603513 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Apr 2013 00:00:00 | ||||||||
| Potential_model (12) | |||||||||
| Disease_relevance | Mutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions. | Homo sapiens | Paper_evidence | WBPaper00024523 | |||||
| WBPaper00042136 | |||||||||
| Accession_evidence | OMIM | 603513 | |||||||
| 605363 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Apr 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000163 | ||||||||
| Models_disease_asserted | WBDOannot00000549 | ||||||||
| WBDOannot00000702 | |||||||||
| WBDOannot00000703 | |||||||||
| Molecular_info | Corresponding_CDS | Y37D8A.23a | |||||||
| Y37D8A.23b | |||||||||
| Y37D8A.23c | |||||||||
| Corresponding_transcript | Y37D8A.23a.1 | ||||||||
| Y37D8A.23b.1 | |||||||||
| Y37D8A.23c.1 | |||||||||
| Other_sequence (65) | |||||||||
| Associated_feature | WBsf645681 | ||||||||
| WBsf994764 | |||||||||
| WBsf994765 | |||||||||
| WBsf1016280 | |||||||||
| WBsf1016281 | |||||||||
| WBsf1016282 | |||||||||
| WBsf225951 | |||||||||
| WBsf225952 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090105 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00077589 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077586 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027872 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089945 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002293 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055883 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090263 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089782 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (136) | |||||||||
| Construct_product | WBCnstr00010179 | ||||||||
| WBCnstr00038179 | |||||||||
| WBCnstr00038181 | |||||||||
| Regulate_expr_cluster | WBPaper00065734:unc-25(e156)_downregulated | ||||||||
| WBPaper00065734:unc-25(e156)_upregulated | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (186) | |||||||||
| Interaction | WBInteraction000000832 | ||||||||
| WBInteraction000001428 | |||||||||
| WBInteraction000002346 | |||||||||
| WBInteraction000003251 | |||||||||
| WBInteraction000003480 | |||||||||
| WBInteraction000003861 | |||||||||
| WBInteraction000005840 | |||||||||
| WBInteraction000008963 | |||||||||
| WBInteraction000008967 | |||||||||
| WBInteraction000009233 | |||||||||
| WBInteraction000028229 | |||||||||
| WBInteraction000028428 | |||||||||
| WBInteraction000028732 | |||||||||
| WBInteraction000029412 | |||||||||
| WBInteraction000030260 | |||||||||
| WBInteraction000031893 | |||||||||
| WBInteraction000038627 | |||||||||
| WBInteraction000040584 | |||||||||
| WBInteraction000041787 | |||||||||
| WBInteraction000043163 | |||||||||
| WBInteraction000045936 | |||||||||
| WBInteraction000052836 | |||||||||
| WBInteraction000052969 | |||||||||
| WBInteraction000126297 | |||||||||
| WBInteraction000126460 | |||||||||
| WBInteraction000126485 | |||||||||
| WBInteraction000126592 | |||||||||
| WBInteraction000127178 | |||||||||
| WBInteraction000165628 | |||||||||
| WBInteraction000165897 | |||||||||
| WBInteraction000165899 | |||||||||
| WBInteraction000165934 | |||||||||
| WBInteraction000166446 | |||||||||
| WBInteraction000167433 | |||||||||
| WBInteraction000220766 | |||||||||
| WBInteraction000227275 | |||||||||
| WBInteraction000299279 | |||||||||
| WBInteraction000367361 | |||||||||
| WBInteraction000376125 | |||||||||
| WBInteraction000501209 | |||||||||
| WBInteraction000501210 | |||||||||
| WBInteraction000501211 | |||||||||
| WBInteraction000501212 | |||||||||
| WBInteraction000501950 | |||||||||
| WBInteraction000517365 | |||||||||
| WBInteraction000517573 | |||||||||
| WBInteraction000520025 | |||||||||
| WBInteraction000524336 | |||||||||
| WBInteraction000551748 | |||||||||
| WBInteraction000555296 | |||||||||
| WBInteraction000558065 | |||||||||
| WBInteraction000558066 | |||||||||
| WBInteraction000580479 | |||||||||
| WBInteraction000583691 | |||||||||
| WBInteraction000584070 | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | III | Position | 20.6616 | Error | 0.04207 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y37D8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 57 | |||||||
| 68 | |||||||||
| 78 | |||||||||
| 6019 | |||||||||
| 6109 | |||||||||
| 7009 | |||||||||
| 7010 | |||||||||
| Multi_point (42) | |||||||||
| Pos_neg_data | 354 | ||||||||
| 8378 | |||||||||
| 8386 | |||||||||
| 8389 | |||||||||
| 8550 | |||||||||
| Reference (216) | |||||||||
| Method | Gene |
