WormBase Tree Display for Gene: WBGene00006762
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WBGene00006762 | SMap | S_parent | Sequence | Y37D8A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143000 | ||||||
Allele (165) | |||||||
Legacy_information | e156 : shrinker contracts both dorsally and ventrally when prodded; slow; poor backing; slightly small; deficient in GABA. ES3 ME2. NA4 (e265 e591). | ||||||
[C.elegansII] e156 : shrinker, contracts both dorsally and ventrally when prodded; slow; loopy Fab; poor backing; slightly small; Exp defect in defecation; deficient in GABA; some neuroanatomical defects (D motorneurons). ES3 ME2. OA>5: e265, e591, sa4, sa25 (similar). Cloned: encodes 416 aa GAD (glutamic aciddecarboxylase), 45% identity to human GAD65,67. unc-25:lacZ expressed in all GABAergic neurons. [Thomas 1990; McIntire et al. 1993; CZ; JT; MT] | |||||||
Strain (51) | |||||||
Component_of_genotype | WBGenotype00000128 | ||||||
WBGenotype00000129 | |||||||
WBGenotype00000130 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (44) | |||||||
Paralog | WBGene00000239 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00001839 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00004981 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006409 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006418 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006562 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00007593 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00015467 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00022427 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | unc-25 encodes the C. elegans ortholog of the GABA neurotransmitter biosynthetic enzyme, glutamic acid decarboxylase (GAD); unc-25 activity is required for GABA synthesis and thus for normal synaptic transmission and GABA-mediated behaviors; UNC-25 is expressed specifically in the 26 GABAergic neurons as soon as they are generated and localizes to cell bodies, axonal branches, and synaptic regions, including some localization to synaptic vesicles; in the 19 type D GABAergic neurons, unc-25 expression is positively regulated by the UNC-30 homeodomain transcription factor, which binds to the unc-25 promoter in a sequence-specific manner. | Paper_evidence | WBPaper00001759 | |||
WBPaper00003350 | |||||||
WBPaper00003619 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 03 Jul 2007 00:00:00 | ||||||
Automated_description | Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in axon; perikaryon; and synapse. Expressed in EF neuron and neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; developmental and epileptic encephalopathy 89; and diabetes mellitus (multiple). Is an ortholog of human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 06 Jun 2019 00:00:00 | ||||||
DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson38202 | ||||||
Date_last_updated | 04 Jun 2018 00:00:00 | ||||||
DOID:0050669 | Homo sapiens | Paper_evidence | WBPaper00024523 | ||||
Accession_evidence | OMIM | 603513 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 22 Apr 2013 00:00:00 | ||||||
Potential_model (12) | |||||||
Disease_relevance | Mutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions. | Homo sapiens | Paper_evidence | WBPaper00024523 | |||
WBPaper00042136 | |||||||
Accession_evidence | OMIM | 603513 | |||||
605363 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 22 Apr 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000163 | ||||||
Models_disease_asserted | WBDOannot00000549 | ||||||
WBDOannot00000702 | |||||||
WBDOannot00000703 | |||||||
Molecular_info | Corresponding_CDS | Y37D8A.23a | |||||
Y37D8A.23b | |||||||
Y37D8A.23c | |||||||
Corresponding_transcript | Y37D8A.23a.1 | ||||||
Y37D8A.23b.1 | |||||||
Y37D8A.23c.1 | |||||||
Other_sequence (65) | |||||||
Associated_feature | WBsf645681 | ||||||
WBsf994764 | |||||||
WBsf994765 | |||||||
WBsf1016280 | |||||||
WBsf1016281 | |||||||
WBsf1016282 | |||||||
WBsf225951 | |||||||
WBsf225952 | |||||||
Experimental_info | RNAi_result | WBRNAi00090105 | Inferred_automatically | RNAi_primary | |||
WBRNAi00077589 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00077586 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027872 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089945 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002293 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055883 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090263 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089782 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (15) | |||||||
Drives_construct (136) | |||||||
Construct_product | WBCnstr00010179 | ||||||
WBCnstr00038179 | |||||||
WBCnstr00038181 | |||||||
Regulate_expr_cluster | WBPaper00065734:unc-25(e156)_downregulated | ||||||
WBPaper00065734:unc-25(e156)_upregulated | |||||||
Microarray_results (30) | |||||||
Expression_cluster (186) | |||||||
Interaction (55) | |||||||
WBProcess | WBbiopr:00000010 | ||||||
Map_info | Map | III | Position | 20.6616 | Error | 0.04207 | |
Well_ordered | |||||||
Positive | Positive_clone | Y37D8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 57 | |||||
68 | |||||||
78 | |||||||
6019 | |||||||
6109 | |||||||
7009 | |||||||
7010 | |||||||
Multi_point (42) | |||||||
Pos_neg_data | 354 | ||||||
8378 | |||||||
8386 | |||||||
8389 | |||||||
8550 | |||||||
Reference (216) | |||||||
Method | Gene |