WormBase Tree Display for Gene: WBGene00006769
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| WBGene00006769 | SMap | S_parent | Sequence | Y37E11C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-33 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y37E11C.1 | ||||||||
| Molecular_name | Y37E11C.1a | ||||||||
| Y37E11C.1a.1 | |||||||||
| CE21557 | |||||||||
| Y37E11C.1b | |||||||||
| CE31638 | |||||||||
| Y37E11C.1c | |||||||||
| CE31639 | |||||||||
| Y37E11C.1b.1 | |||||||||
| Y37E11C.1c.1 | |||||||||
| Other_name | CELE_Y37E11C.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | unc-33 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006769 | |||||
| WormFlux | gene | WBGene00006769 | |||||||
| NDB | locus_tag | CELE_Y37E11C.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006769|UniProtKB=Q01630 | |||||||
| family | PTHR11647 | ||||||||
| NCBI | gene | 177112 | |||||||
| RefSeq | protein | NM_001380147.1 | |||||||
| NM_001380148.1 | |||||||||
| NM_001038349.4 | |||||||||
| SwissProt | UniProtAcc | Q01630 | |||||||
| TrEMBL | UniProtAcc | U4PLJ8 | |||||||
| UniProt_GCRP | UniProtAcc | Q01630 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143034 | ||||||||
| Allele (224) | |||||||||
| Possibly_affected_by | WBVar02156987 | ||||||||
| Legacy_information | e204 : very slow almost paralysed tends to curl dumpyish; weak FITC uptake; amphid phasmid PDE axons abnormal; abnormal neuronal microtubules. ES3 ME0. NA5 (e572 e735). | ||||||||
| See also e572, e1193, e1261, e1358 | |||||||||
| [C.elegansII] e204 : very slow, almost paralysed; tends to curl; dumpyish; weak FITC uptake; amphid, phasmid, PDE, PVP axons abnormal; multiple defects in axonogenesis; abnormally abundant neuronal microtubules. ES3 ME0. OA>10: e572, e735, e1358, m7,mn260::Tc4, rh1030::Tc4, etc. Cloned: 2.8, 3.3, 3.8 kb transcripts (different 5' ends) encoding predicted 523 aa, 679 aa, 854 aa proteins with similarity to collapsin??? Antibody stains all neuron processes in larvae and adults. [Hedgecock et al. 1985; Li et al. 1992; EH; SP] | |||||||||
| [Li W] mn260 is Tc4 insertion in exon VII of longest (3.8kb) unc-33 transcript. rh1030 same insertion site, modified Tc4 element. | |||||||||
| Strain (29) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP4092 | ||||||||
| Ortholog (37) | |||||||||
| Paralog | WBGene00000963 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000964 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages. | Paper_evidence | WBPaper00001622 | |||||
| WBPaper00002665 | |||||||||
| WBPaper00004362 | |||||||||
| WBPaper00010044 | |||||||||
| WBPaper00025204 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Jun 2005 00:00:00 | ||||||||
| Automated_description | Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and regulation of locomotion. Located in neuron projection. Expressed in amphid socket cell; neuroblasts; neurons; pharyngeal cell; and somatic nervous system. Is an ortholog of human DPYSL2 (dihydropyrimidinase like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y37E11C.1a | |||||||
| Y37E11C.1b | |||||||||
| Y37E11C.1c | |||||||||
| Corresponding_CDS_history | Y37E11C.1:wp82 | ||||||||
| Y37E11C.1a:wp145 | |||||||||
| Y37E11C.1b:wp145 | |||||||||
| Y37E11C.1c:wp145 | |||||||||
| Y37E11C.1c:wp273 | |||||||||
| Corresponding_transcript | Y37E11C.1a.1 | ||||||||
| Y37E11C.1b.1 | |||||||||
| Y37E11C.1c.1 | |||||||||
| Other_sequence (38) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103588 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00020239 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00086120 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055925 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055924 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089774 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090316 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030274 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090157 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089998 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00001590 | ||||||||
| WBCnstr00001591 | |||||||||
| WBCnstr00006869 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000953 | ||||||||
| WBAntibody00000954 | |||||||||
| WBAntibody00001546 | |||||||||
| WBAntibody00001788 | |||||||||
| WBAntibody00001922 | |||||||||
| WBAntibody00002299 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (69) | |||||||||
| WBProcess | WBbiopr:00000010 | ||||||||
| Map_info | Map | IV | Position | -3.30458 | Error | 0.013709 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mDp4 | |||||||
| Positive_clone | EH#143 | ||||||||
| Y37E11 | |||||||||
| Y37E11C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 99 | |||||||
| 484 | |||||||||
| 824 | |||||||||
| 1643 | |||||||||
| 3276 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data | 9110 | ||||||||
| Reference (123) | |||||||||
| Remark | extracted from Li et al. (1992) | ||||||||
| sequence match was given and M57.b and.c but theses overlap with Y37E11C.c which has not been annotated yet. sdm 11/00. will probably acquire name Y37E11C.1 | |||||||||
| Method | Gene |
