| WBGene00006772 | SMap | S_parent | Sequence | C50C3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-36 | Person_evidence | WBPerson261 |
| | | Sequence_name | C50C3.9 |
| | | Molecular_name | C50C3.9a |
| | | | C50C3.9a.1 |
| | | | CE32168 |
| | | | C50C3.9b |
| | | | CE39702 |
| | | | C50C3.9c |
| | | | CE24860 |
| | | | C50C3.9b.1 |
| | | | C50C3.9c.1 |
| | | Other_name | unc-72 |
| | | | eT1 |
| | | | CELE_C50C3.9 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-36 |
| | DB_info | Database | WormQTL | gene | WBGene00006772 |
| | | | WormFlux | gene | WBGene00006772 |
| | | | NDB | locus_tag | CELE_C50C3.9 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006772|UniProtKB=P34374 |
| | | | | family | PTHR10166 |
| | | | NCBI | gene | 176155 |
| | | | RefSeq | protein | NM_001268026.4 |
| | | | | | NM_001047387.4 |
| | | | | | NM_001047386.6 |
| | | | SwissProt | UniProtAcc | P34374 |
| | | | TrEMBL | UniProtAcc | G4S4A1 |
| | | | UniProt_GCRP | UniProtAcc | P34374 |
| | | | OMIM | gene | 114204 |
| | | | | | 608171 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143063 |
| | Allele (85) |
| | Legacy_information | e251 : very slow almost paralysed thin and slightly small; normal ventral nerve cord ultrastructure. ES3 ME0. NA5 (e418 (resembles e251); eT1(III;V) (pka unc-72) fails to complement e251 (ME1)). |
| | | See unc-36. |
| | | [Leon Avery] unc-36 mutants have two abnormal feeding phenotypes: pumping is slow and irregular, and in addition they have slippery corpora and isthmi. unc-36 worms are somewhat hypersensitive to arecoline, most L1s being arrested by 5 mM. |
| | | See also ad698, e873, e1501, e2341 |
| | | [C.elegansII] e251 : very slow, almost paralysed, thin; loopy at rest; normal ventral nerve cord ultrastructure; Ric; hypersensitive to serotonin, fails to adapt to dopamine (likeUnc-2); hypersensitive to calcium channel modulators such as verapamil. Pharyngeal pumping slow and irregular, slippery corpus and isthmus; increased sensitivity to arecoline. Mosaic analysis indicates focus in nervous system. ES3 ME0. OA>8: e418 (resembles e251); eT1(III;V) (pka unc-72(e873), presumed breakpoint, ME1),e1501, e2341, ad698, etc. Cloned: encodes predicted proteins with similarity (~45% identity) to alpha2 subunit of L-type calcium channel. [Brenner 1974; Avery 1993; Nguyen et al. 1995; MT] |
| | Strain (72) |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Ortholog (54) |
| | Paralog | WBGene00007041 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | unc-36 encodes an alpha2/delta subunit of a voltage-gated calcium channel; unc-36 is required for normal locomotion and proper intracellular trafficking, presynaptic localization and functional maturation of the UNC-2 alpha1 subunit of a C. elegans CaV2 channel in sensory and motor neurons; unc-36 also functions in a calcium-dependent pathway that establishes left-right asymmetry in the nervous system during development; recordings of voltage-dependent calcium currents indicate that UNC-36 regulates voltage dependence, kinetics, and conductance of the EGL-19 alpha1 subunit of the body wall muscle voltage-dependent calcium channel; unc-36 is expressed in muscle cells and motor neurons; an UNC-36::GFP localizes to the endoplasmic reticulum and the plasma membrane. | Paper_evidence | WBPaper00027747 |
| | | | | | WBPaper00028339 |
| | | | | | WBPaper00031175 |
| | | | | | WBPaper00035163 |
| | | | | | WBPaper00040141 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 01 Sep 2011 00:00:00 |
| | | Automated_description | Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in several processes, including egg-laying behavior; pharyngeal pumping; and serotonin receptor signaling pathway. Located in endoplasmic reticulum membrane and plasma membrane. Part of voltage-gated calcium channel complex. Expressed in head muscle; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110 and retinal cone dystrophy 4. Is an ortholog of human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0070395 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1399) |
| | | DOID:0081023 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20202) |
| Molecular_info | Corresponding_CDS | C50C3.9a |
| | | C50C3.9b |
| | | C50C3.9c |
| | Corresponding_CDS_history | C50C3.9:wp88 |
| | | C50C3.9:wp154 |
| | Corresponding_transcript | C50C3.9a.1 |
| | | C50C3.9b.1 |
| | | C50C3.9c.1 |
| | Other_sequence (28) |
| | Associated_feature | WBsf667141 |
| | | WBsf993264 |
| | | WBsf993265 |
| | | WBsf227092 |
| | | WBsf227093 |
| Experimental_info | RNAi_result (32) |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00002870 |
| | | WBCnstr00006429 |
| | | WBCnstr00006431 |
| | | WBCnstr00006517 |
| | | WBCnstr00006518 |
| | | WBCnstr00012960 |
| | | WBCnstr00019650 |
| | | WBCnstr00034161 |
| | Construct_product | WBCnstr00006429 |
| | | WBCnstr00006431 |
| | | WBCnstr00006517 |
| | | WBCnstr00006518 |
| | | WBCnstr00011505 |
| | | WBCnstr00019650 |
| | | WBCnstr00019678 |
| | | WBCnstr00034161 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058942:henn-1(pk2295)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AWC |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RID |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:hrde-1(tm1200)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061651:RIA_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | cgc4386_cluster_5_1 |
| | | cgc4489_group_19 |
| | | cgc4489_group_20 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (38) |
| | Anatomy_function | WBbtf0543 |
| | | WBbtf0545 |
| | | WBbtf0546 |
| Map_info | Map | III | Position | -0.373497 | Error | 0.001179 |
| | Well_ordered |
| | Positive | Inside_rearr | eT1 |
| | | | nDp2 |
| | | | sDp3 |
| | | | ctDp11 |
| | | Positive_clone | C50C3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | ZK362 |
| | Negative | Outside_rearr | tnDf2 |
| | Mapping_data | 2_point (13) |
| | | Multi_point (107) |
| | | Pos_neg_data (11) |
| Reference (187) |
| Method | Gene |
