WormBase Tree Display for Gene: WBGene00006784
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WBGene00006784 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T21C12 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143164 | ||||||
Allele (220) | |||||||
Legacy_information | e382 : shrinker contracts both dorsally and ventrally when prodded slow poor backing slightly small. ES3 ME2. NA6 (e407 e468). | ||||||
See also e641, n1324 | |||||||
[C.elegansII] e382 : shrinker, contracts both dorsally and ventrally when prodded; slow; poor backing, slightly small. Probable defect in inhibitory GABA receptor function. ES3 ME2. OA>5: e407, e468, e929, n1324 etc. Cloned: encodes predicted GABA-A receptor. In probable operon with two other GABA receptor subunits. [Brenner 1974; McIntire et al. 1993; EG; MT] | |||||||
Strain (14) | |||||||
Component_of_genotype | WBGenotype00000119 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Ortholog (37) | |||||||
Paralog (100) | |||||||
Structured_description | Concise_description | unc-49 encodes multiple subunits of a heteromeric GABA receptor; unc-49 activity is required for postsynaptic GABA responsiveness and thus for normal regulation of locomotion; UNC-49::GFP reporter fusions for at least two isoforms are expressed in dorsal and ventral head and body wall muscles, with isoform-specific expression also seen in the sphincter muscle; UNC-49::GFP subcellular localization is most prominent at neuromuscular junctions; in Xenopus oocytes and mammalian tissue culture cells, two UNC-49 subunits, UNC-49B and UNC-49C, are able to form a functional heteromeric GABA receptor. | Paper_evidence | WBPaper00003576 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 24 Aug 2007 00:00:00 | ||||||
Automated_description | Predicted to enable transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060194 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 18 May 2022 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00001202 | ||||||
WBDOannot00001203 | |||||||
Molecular_info | Corresponding_CDS (13) | ||||||
Corresponding_CDS_history | T21C12.1a:wp227 | ||||||
T21C12.1a:wp239 | |||||||
T21C12.1g:wp275 | |||||||
Corresponding_transcript (14) | |||||||
Other_sequence (51) | |||||||
Associated_feature (25) | |||||||
Experimental_info | RNAi_result | WBRNAi00090257 | Inferred_automatically | RNAi_primary | |||
WBRNAi00053708 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089728 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066348 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027895 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00000954 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090099 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00018961 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089939 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00006214 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1283 | ||||||
Expr15907 | |||||||
Expr1027570 | |||||||
Expr1032855 | |||||||
Expr1157259 | |||||||
Expr1200291 | |||||||
Expr2017881 | |||||||
Expr2036017 | |||||||
Marker2 | |||||||
Marker19 | |||||||
Drives_construct | WBCnstr00001626 | ||||||
WBCnstr00001627 | |||||||
WBCnstr00006881 | |||||||
WBCnstr00010191 | |||||||
WBCnstr00019381 | |||||||
WBCnstr00020581 | |||||||
WBCnstr00034153 | |||||||
WBCnstr00042588 | |||||||
Construct_product | WBCnstr00001627 | ||||||
WBCnstr00006881 | |||||||
WBCnstr00016180 | |||||||
WBCnstr00019381 | |||||||
WBCnstr00020010 | |||||||
WBCnstr00020581 | |||||||
WBCnstr00021428 | |||||||
WBCnstr00034153 | |||||||
Antibody | WBAntibody00000613 | ||||||
WBAntibody00001987 | |||||||
Microarray_results (88) | |||||||
Expression_cluster (187) | |||||||
Interaction (31) | |||||||
WBProcess | WBbiopr:00000010 | ||||||
Map_info | Map | III | Position | 3.35021 | Error | 0.089636 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf40 | |||||
mT1 | |||||||
Positive_clone | T21C12 | Person_evidence | WBPerson39 | ||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point | 73 | |||||
86 | |||||||
589 | |||||||
3249 | |||||||
Multi_point (55) | |||||||
Pos_neg_data | 3242 | ||||||
3250 | |||||||
3251 | |||||||
Reference (138) | |||||||
Remark | Sequence connection from [Bamber BA] | ||||||
Method | Gene |