WormBase Tree Display for Gene: WBGene00006807

WBGene00006807 Evidence: Paper_evidence: WBPaper00012816
  SMap: S_parent: Sequence: C17D12
  Identity: Version: 1
    Name: CGC_name: unc-75 Person_evidence: WBPerson261
      Sequence_name: C17D12.2
      Molecular_name (12)
      Other_name: CELE_C17D12.2 Accession_evidence: NDB BX284601
      Public_name: unc-75
    DB_info: Database: AceView gene 1M191
        WormQTL gene WBGene00006807
        WormFlux gene WBGene00006807
        NDB locus_tag CELE_C17D12.2
        Panther gene CAEEL|WormBase=WBGene00006807|UniProtKB=G5EE68
          family PTHR24012
        NCBI gene 182722
        RefSeq protein NM_001313479.3
            NM_001313478.3
            NM_001313480.3
            NM_060557.7
        TrEMBL UniProtAcc A0A0K3AR68
            A0A0K3AWH2
            G5EE68
            A0A0K3ATM0
        UniProt_GCRP UniProtAcc G5EE68
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143628
    Allele (250)
    Legacy_information: e950 : weak coiler especially in reverse; moves forward well; sluggish; short. ES3 ME2. NA1.
      [C.elegansII] e950 : weak coiler especially in reverse; moves forward well; sluggish; short; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974; Nguyen et al. 1995; KR; RM]
    Strain (32)
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (59)
    Paralog: WBGene00001340 Caenorhabditis elegans From_analysis: Inparanoid_8
      WBGene00017135 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017140 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019510 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019881 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020354 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM that is orthologous to the mammalian CELF/BrunoL proteins that control pre-mRNA splicing; UNC-75 is required for neuron-specific splicing of unc-32 mRNA; UNC-75 binds the unc-32 intron 7a in vitro; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission; UNC-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. Paper_evidence: WBPaper00006029
            WBPaper00012816
            WBPaper00042088
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 26 Mar 2013 00:00:00
      Automated_description: Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Expressed in neurons and pharyngeal gland cell. Is an ortholog of human CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C17D12.2a
      C17D12.2b
      C17D12.2c
      C17D12.2d
    Corresponding_CDS_history: C17D12.2:wp76
      C17D12.2:wp103
      C17D12.2:wp114
    Corresponding_transcript: C17D12.2a.1
      C17D12.2b.1
      C17D12.2c.1
      C17D12.2d.1
    Other_sequence (21)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00002963 Inferred_automatically: RNAi_primary
      WBRNAi00089748 Inferred_automatically: RNAi_primary
      WBRNAi00002961 Inferred_automatically: RNAi_primary
      WBRNAi00028998 Inferred_automatically: RNAi_primary
      WBRNAi00040789 Inferred_automatically: RNAi_primary
      WBRNAi00090164 Inferred_automatically: RNAi_primary
      WBRNAi00116889 Inferred_automatically: RNAi_primary
      WBRNAi00090323 Inferred_automatically: RNAi_primary
      WBRNAi00090005 Inferred_automatically: RNAi_primary
      WBRNAi00040788 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2668
      Expr2669
      Expr1013866
      Expr1032874
      Expr1144828
      Expr2017904
      Expr2036040
    Drives_construct: WBCnstr00010893
      WBCnstr00010894
      WBCnstr00016124
    Construct_product: WBCnstr00010894
      WBCnstr00022989
      WBCnstr00022991
    Regulate_expr_cluster: WBPaper00049626:UNC-75_target
    Antibody: WBAntibody00002411
    Microarray_results (21)
    Expression_cluster (160)
    Interaction (33)
    Anatomy_function: WBbtf0228
      WBbtf0229
  Map_info: Map: I Position: 9.28192 Error: 0.021291
    Well_ordered
    Positive: Inside_rearr: nDp4
      Positive_clone: C17D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: dxDf2
    Mapping_data: 2_point (17)
      Multi_point (79)
      Pos_neg_data (20)
    Landmark_gene
  Reference (63)
  Method: Gene