| WBGene00006808 | SMap | S_parent | Sequence | C01G10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-76 | Person_evidence | WBPerson261 |
| | | Sequence_name | C01G10.11 |
| | | Molecular_name (18) |
| | | Other_name | CELE_C01G10.11 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-76 |
| | DB_info | Database | AceView | gene | 5P559 |
| | | | WormQTL | gene | WBGene00006808 |
| | | | WormFlux | gene | WBGene00006808 |
| | | | NDB | locus_tag | CELE_C01G10.11 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006808|UniProtKB=E0AHC6 |
| | | | | family | PTHR12394 |
| | | | NCBI | gene | 180014 |
| | | | RefSeq | protein | NM_001269717.3 |
| | | | | | NM_001269716.3 |
| | | | | | NM_001269719.3 |
| | | | | | NM_001269718.3 |
| | | | | | NM_074311.7 |
| | | | | | NM_171553.6 |
| | | | TREEFAM | TREEFAM_ID | TF313128 |
| | | | TrEMBL | UniProtAcc | E0AHC6 |
| | | | | | E0AHC4 |
| | | | | | E0AHC3 |
| | | | | | E0AHC5 |
| | | | | | Q7JL61 |
| | | | | | Q7JL62 |
| | | | UniProt_GCRP | UniProtAcc | E0AHC6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143591 |
| | Allele (163) |
| | Legacy_information | e911pdi : inactive tends to curl dumpyish; Egl-c; amphid phasmid PDE axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions often fail to connect to dorsal nerve cord. ES3 ME0. NA1. |
| | | [C.elegansII] e911pdi : inactive, tends to curl, dumpyish; Egl-c; amphid, phasmid, PDE, PVP, other axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions, often fail to connect to dorsal nervecord. Defects in axonal elongation and fasciculation along nerve cords. ES3 ME0. NA1. Cloned: 1.8 kb transcripts, encode predicted 385 or 376 aa novel proteins. Epitope-tagged UNC-76 detected in axons. [Hedgecock et al. 1985; McIntire et al. 1992; MT] |
| | Strain (54) |
| | RNASeq_FPKM (74) |
| | GO_annotation (22) |
| | Ortholog (39) |
| | Structured_description | Concise_description | unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies. | Paper_evidence | WBPaper00002751 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 31 May 2006 00:00:00 |
| | | Automated_description | Enables syntaxin binding activity. Involved in anterograde axonal protein transport; axonal fasciculation; and regulation of cellular component organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in neurons and somatic nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human FEZ1 (fasciculation and elongation protein zeta 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3659) |
| Molecular_info | Corresponding_CDS | C01G10.11a |
| | | C01G10.11b |
| | | C01G10.11c |
| | | C01G10.11d |
| | | C01G10.11e |
| | | C01G10.11f |
| | Corresponding_CDS_history | C01G10.11a:wp151 |
| | | C01G10.11b:wp151 |
| | Corresponding_transcript | C01G10.11a.1 |
| | | C01G10.11b.1 |
| | | C01G10.11c.1 |
| | | C01G10.11d.1 |
| | | C01G10.11e.1 |
| | | C01G10.11f.1 |
| | Other_sequence (20) |
| | Associated_feature (21) |
| Experimental_info | RNAi_result | WBRNAi00089749 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027631 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00009926 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089948 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039322 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086127 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090266 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090108 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1621 |
| | | Expr1019687 |
| | | Expr1032875 |
| | | Expr1143433 |
| | | Expr2017905 |
| | | Expr2036041 |
| | Drives_construct | WBCnstr00001401 |
| | | WBCnstr00034141 |
| | Construct_product (15) |
| | Antibody | WBAntibody00000143 |
| | Microarray_results (40) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:A-class-motor-neurons_CoreEnriched |
| | | WBPaper00037950:A-class-motor-neurons_embryo_enriched |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_larva_enriched |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00040209:B.thuringiensis_upregulated_N2 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057254:MWCNT_upregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061274:hypergravity_10xg_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_PLM |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:dld-1-skn-1_16701 |
| | | WBPaper00061527:zfp-1_3975-smk-1_2897 |
| | | WBPaper00061651:AVJ_enriched |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061651:DA_enriched |
| | | WBPaper00061651:DB01_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:PVC_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00061651:VC_enriched |
| | | WBPaper00061651:VD_DD_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_downregulated_starved |
| | | WBPaper00064055:trl-1(cas1078)_downregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1078)_downregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064505:tamoxifen_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_4 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00030985:Enterococcus_faecalis_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_0.2mM_Down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (37) |
| Map_info | Map | V | Position | 7.32052 | Error | 0.012665 |
| | Well_ordered |
| | Positive | Positive_clone | C01G10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | C08C1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | nDf31 |
| | | | ozDf1 |
| | Mapping_data | 2_point (15) |
| | | Multi_point (103) |
| | | Pos_neg_data | 4288 |
| | | | 4289 |
| | | | 4290 |
| | | | 4304 |
| | | | 8977 |
| | Landmark_gene |
| Reference (130) |
| Method | Gene |
